An open-label, phase IV randomised controlled trial of two schedules of a four-component meningococcal B vaccine in UK preterm infants

Objective: To compare immunological responses of preterm infants to a four-component meningococcal B vaccine (4CMenB; Bexsero) following a 2+1 vs a 3+1 schedule, and to describe reactogenicity of routine vaccines. Design: An open-label, phase IV randomised study conducted across six UK sites. Setting: Neonatal units, postnatal wards, community recruitment following discharge. Participants: 129 preterm infants born at a gestation of 38.0°C than those in the 2+1 group who did not (group 2+1: 2% (n=1); 3+1: 14% (n=9); p=0.02). Conclusions: Both schedules were immunogenic in preterm infants, although a lower response against strain NZ98/254 was seen in the 2+1 schedule; ongoing disease surveillance is important in understanding the clinical significance of this difference. Trial registration number: NCT03125616

An open-label, phase IV randomised controlled trial of two schedules of a four-component meningococcal B vaccine in UK preterm infants

Objective: To compare immunological responses of preterm infants to a four-component meningococcal B vaccine (4CMenB; Bexsero) following a 2+1 vs a 3+1 schedule, and to describe reactogenicity of routine vaccines.   Design: An open-label, phase IV randomised study conducted across six UK sites.   Setting: Neonatal units, postnatal wards, community recruitment following discharge.   Participants: 129 preterm infants born at a gestation of 38.0°C than those in the 2+1 group who did not (group 2+1: 2% (n=1); 3+1: 14% (n=9); p=0.02).   Conclusions: Both schedules were immunogenic in preterm infants, although a lower response against strain NZ98/254 was seen in the 2+1 schedule; ongoing disease surveillance is important in understanding the clinical significance of this difference.   Trial registration number NCT03125616

Introducing eastern orthodox theology

xx, 172 p.; 23 cm

The origins of the Christian mystical tradition. From Plate to Denys

xvii, 215 p.; 20 cm

Pope Martin I and Maximos the Confessor in Their Struggle for Orthodoxy Against the Empire

(VLID)276569