10 research outputs found
Nature meets nurture: molecular genetics of gastric cancer
The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming and the relevant importance of some of these molecules is too often unclear. This review serves to bring us up-to-date with the latest findings as well as to look at the larger picture in terms of how to tackle the problem of solving this multi-piece puzzle. In this review, the environmental nurturing of intestinal cancer is discussed, beginning with epidemiology (known causative factors for inducing molecular change), an update of H. pylori research, including the role of inflammation and stem cells in premalignant lesions. The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed
Tuning of Magnetic and Optical Properties of Co0.8Zn0.2Fe2O4 Spinel Ferrite Thin Films Based on Post Annealing Temperature
Influence of indium substitution and microstructure changes on the magnetic properties evolution of Y3Fe5−xInxO12 (x = 0.0–0.4)
Permeability Spectral Analysis and Determination of Microstructural Parameters for Mn0.7+xZn0.3SixFe2-2xO4 Series
Superparamagnetic cobalt-substituted copper zinc ferrialuminate: synthesis, morphological, magnetic and dielectric properties investigation
Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo
The effect of Sb on the electrical and magnetic properties of Ni-Zn ferrites prepared by sol–gel autocombustion method
Role of the EpCAM (CD326) in prostate cancer metastasis and progression
Despite significant advances in surgery, radiotherapy and chemotherapy to treat prostate cancer (CaP), many patients die of secondary disease (metastases). Current therapeutic approaches are limited, and there is no cure for metastatic castration-resistant prostate cancer (CRPC). Epithelial cell adhesion molecule (EpCAM, also known as CD326) is a transmembrane glycoprotein that is highly expressed in rapidly proliferating carcinomas and plays an important role in the prevention of cell–cell adhesion, cell signalling, migration, proliferation and differentiation. Stably and highly expressed EpCAM has been found in primary CaP tissues, effusions and CaP metastases, making it an ideal candidate of tumour-associated antigen to detect metastasis of CaP cells in the circulation as well as a promising therapeutic target to control metastatic CRPC disease. In this review, we discuss the implications of the newly identified roles of EpCAM in terms of its diagnostic and metastatic relevance to CaP. We also summarize EpCAM expression in human CaP and EpCAM-mediated signalling pathways in cancer metastasis. Finally, emerging and innovative approaches to the management of the disease and expanding potential therapeutic applications of EpCAM for targeted strategies in future CaP therapy will be explored.<br /