5 research outputs found
A snapshot of EU publications in sleep research: A scientometric survey
- Author
- Publication venue
- 'Akademiai Kiado Zrt.'
- Publication date
- Field of study
Acid–base chemistry of plasma: consolidation of the traditional and modern approaches from a mathematical and clinical perspective
- Author
- AM Leeuven Van
- EW Wooten
- EW Wooten
- GC Funk
- HR Staempfli
- J Figge
- J Figge
- J Figge
- J. Handy
- JA Kellum
- JA Kellum
- JA Yahwak
- LJ Kaplan
- M Emmet
- M Goldberg
- M Moviat
- N Balasubramanyan
- O Siggaard-Andersen
- O Siggaard-Andersen
- O Siggaard-Andersen
- O Siggaard-Andersen
- O Siggaard-Andersen
- O Siggaard-Andersen
- P Lloyd
- PA Stewart
- PD Constable
- PD Constable
- PD Constable
- PD Watson
- PM Honore
- RB Singer
- S. E. Rees
- S. Matousek
- SD Winter
- SE Rees
- SE Rees
- V Fencl
- WB Schwartz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular characterization of a novel picobirnavirus in a chicken
- Author
- A Kapoor
- AM Collier
- B Ganesh
- BD Costa
- Beatrix Kapusinszky
- BI Rossen
- Csaba Nemes
- EM Symonds
- Eric Delwart
- G Gonzales
- G Sun
- G Zhao
- Gábor Reuter
- H Verma
- HG Pereira
- HG Pereira
- J Shine
- JG Victoria
- JM Day
- K Tamura
- L Li
- M Leeuven van
- M Wakuda
- N Conceição-Neto
- P Stanssens
- PC Woo
- PCY Woo
- Péter Pankovics
- R Bodewes
- R Duraisamy
- R Navarro
- R Navarro
- S Duquerroy
- SQ Le
- SR Krishnamurthy
- T Zhang
- TF Ng
- U Kuhar
- YS Malik
- Ákos Boros
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Potential protective effect of sunitinib after administration of diclofenac: biochemical and histopathological drug-drug interaction assessment in a mouse model
- Author
- A Armour
- A Petroianu
- AM Weise
- AYL Lim
- B Chuasuwan
- BI Rini
- C Bello
- CD Britten
- CL Bello
- DB Njoku
- DJ Waldon
- E Eisenberg
- E Ridruejo
- G Stirnimann
- GW Soo
- H Huang
- H Li
- I Nassar
- I Nassar
- Ignacio Segarra
- J Gu
- J Haznedar
- J Medioni
- J Vane
- JA Hinson
- JA Mitchell
- Jian Ren Tan
- JJ Hiles
- John Paul Judson
- JS Lagas
- JS Leeuven van
- JS Leeuwen van
- K Yamaki
- KD Jhaveri
- L Struthmann
- LE Ng
- LJ Yu
- LQM Chow
- ME Lacouture
- MH Chen
- Nagaraja Haleagrahara
- NP Erp van
- PJ Christo
- Q Zhou
- R Roskoski
- RP Riechelmann
- RP Riechelmann
- RT O’Brien
- S Hu
- S Ilic
- S Sarda
- SC Tang
- SC Tang
- SC Weiss
- SJ Bowlin
- Srikumar Chakravarthi
- SS Singhal
- SY Tan
- T Nicholaou
- T Usui
- TF Chu
- TJ Abrams
- U Boelsterli
- VL Goodman
- Y Liu
- Y Masubuchi
- Y Shimeda
- Publication venue
- Springer
- Publication date
- 01/07/2013
- Field of study
Sunitinib is a tyrosine kinase inhibitor for GIST and advanced renal cell carcinoma. Diclofenac is used in cancer pain management. Coadministration may mediate P450 toxicity. We evaluate their interaction, assessing biomarkers ALT, AST, BUN, creatinine, and histopathological changes in the liver, kidney, heart, brain, and spleen. ICR mice (male, n = 6 per group/dose) were administered saline (group A) or 30 mg/kg diclofenac ip (group B), or sunitinib po at 25, 50, 80, 100, 140 mg/kg (group C) or combination of diclofenac (30 mg/kg, ip) and sunitinib (25, 50, 80, 100, 140 mg/kg po). Diclofenac was administered 15 min before sunitinib, mice were euthanized 4 h post-sunitinib dose, and biomarkers and tissue histopathology were assessed. AST was 92.2 ± 8.0 U/L in group A and 159.7 ± 14.6 U/L in group B (p < 0.05); in group C, it the range was 105.1-152.6 U/L, and in group D, it was 156.0-209.5 U/L (p < 0.05). ALT was 48.9 ± 1.6 U/L (group A), 95.1 ± 4.5 U/L (p < 0.05) in group B, and 50.5-77.5 U/L in group C and 82.3-115.6 U/L after coadministration (p < 0.05). Renal function biomarker BUN was 16.3 ± 0.6 mg/dl (group A) and increased to 29.9 ± 2.6 mg/dl in group B (p < 0.05) and it the range was 19.1-33.3 mg/dl (p < 0.05) and 26.9-40.8 mg/dl in groups C and D, respectively. Creatinine was 5.9 pmol/ml in group A; 6.2 pmol/ml in group B (p < 0.01), and the range was 6.0-6.2 and 6.2-6.4 pmol/ml in groups C and D, respectively (p < 0.05 for D). Histopathological assessment (vascular and inflammation damages) showed toxicity in group B (p < 0.05) and mild toxicity in group C. Damage was significantly lesser in group D than group B (p < 0.05). Spleen only showed toxicity after coadministration. These results suggest vascular and inflammation protective effects of sunitinib, not shown after biomarker analysis
Organolead Compounds
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- S Kosmider
- S Kosmider
- S Mishima
- S Mishima
- S Mishima
- S Mishima
- S Mishima
- S Moeschlin
- S Nagasava
- S Pasynkiewicz
- S Plaza
- S Rapsomanikis
- S Regunathan
- S Regunathan
- S Regunathan
- S Regunathan
- S Rokhlin
- S Sandor
- S Urushibara
- S Utsumi
- S Vignes
- S Vuckovic
- S Warwel
- S Warwel
- S Wawzonek
- S-G Jiang
- S-G Jiang
- S.E. Cook
- SA Estes
- SA Estes
- SA Estes
- SC Bondy
- SC Bondy
- SE Birnie
- SE Birnie
- SE Birnie
- SE Birnie
- SE Cook
- SE Cook
- SE Cook
- SE Cook
- SE Cook
- SE Cook
- SE Cook
- SE Krein
- SE Krein
- SF Birch
- SF Birch
- SF Birch
- SG Jiang
- SG Jiang
- SG Jiang
- SG Smirnov
- SG Smirnov
- SI Dracheva
- SI Kirsh
- SI Kubarev
- SJ Cook
- SJ Gentry
- SJ Leonardi
- SJ Marshall
- SJ Mora De
- SJW Price
- SJW Price
- SK Kyuregyan
- SM Farroha
- Societa Edison S.p.A. — Settore Chimico
- Societa Edison S.p.A.-Settore Chimico
- SP Nickerson
- SR Belova
- SR Henderson
- SR Henderson
- SR Newman
- SS Baranov
- SS Epstein
- ST Holding
- SV Syavtsillo
- SV Syavtsillo
- SW Benson
- SW Benson
- SW Chaikin
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- Szczepanski
- T Balint
- T Breyhan
- T Dillon
- T Dillon
- T Dowling
- T Dowling
- T Dowling
- T Fellenberg von
- T Fellenberg von
- T Fernandez
- T Hammerich
- T Hammerich
- T Hammerich
- T Huff
- T Ishii
- T Katou
- T Leipert
- T Li
- T Li
- T Matsui
- T Midgley
- T Midgley
- T Midgley Jr
- T Mori
- T Myvanishi
- T Niculescu
- T Nielsen
- T Nielsen
- T Nielsen
- T Nielsen
- T Nishishita
- T Okada
- T Schroeder
- T Schroeder
- T SmI
- T Tsuruta
- T Wartik
- T Wilkowa
- T-M Li
- T.H. Pearson
- TA Boyd
- TA Boyd
- TAK Al-Allaf
- TAK Al-Allaf
- TCS Ruo
- TG Pearson
- TG Pearson
- TG Pearson
- TG Pearson
- TH Coffield
- THM Manasev
- TJ Chow
- TJ Chow
- TK Hanson
- TL Cottrell
- TL Shkorbatova
- TL Shkorbatova
- TM Sugden
- TM Vickrey
- TM Vickrey
- TO Aulfield
- TP Kashcheeva
- TP Kashcheeva
- TP Korolenko
- TR Robinson
- TR Robinson
- TR Robinson
- TV Krishnan
- TV Krishnan
- U Ambanelli
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- U Belluco
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- U Belluco
- U Belluco
- U Belluco
- U Kunze
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- V Arunachalam
- V Bade
- V Berenguer
- V Cantuti
- V Cantuti
- V Cosic
- V Emel’yanov
- V Emel’yanov
- V Foá
- V Gavrilov
- V Gavrilov
- V Genta
- V Genta
- V Genta
- V Giuliani
- V Giuliani
- V Giuliani
- V Giuliani
- V Hiev
- V Hiev
- V Hlavacek
- V Hlavacek
- V Kabaivanov
- V Kabaivanov
- V Kuppu Rao
- V Prever
- V Scarinci
- V Scarinci
- V Veljkovic
- V Vesely
- VA Green
- VA Khrustaleva
- VA Khrustaleva
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Smith
- VC Demel Jr.
- VD Efimova
- VE Emel’yanov
- VF Mironov
- VF Mironov
- VF Mironov
- VF Traven
- VG Gurevich
- VG Kuleshov
- VG Kuleshov
- VG Kuleshov
- VG Tsvetkov
- VH Dibeler
- VH Dibeler
- VH Dibeler
- VI Faerman
- VI Tel’noi
- VI Tel’noi
- VI Tel’noi
- VI Tel’noi
- VI Tel’noi
- VK Khairullin
- VK Khairullin
- VK Khanina
- VN Ipatieff
- VN Ipatieff
- VN Ipatieff
- VN Ipatieff
- VN Ipat’ev
- VP Finelonov
- VP Muzychenko
- VS Azev
- VS Azev
- VS Azev
- VS Azev
- VS Azev
- VS Trievskii
- VV Bushin
- VV Bushin
- VV Bushin
- VV Bushin
- VV Bushin
- VV Korshak
- VV Korshak
- VV Korshak
- VV Korshak
- VV Ovchinnikov
- W Bai
- W Bai
- W Bai
- W Biltz
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Chlupacek
- W Cornelius
- W Dabeistein
- W Dahlig
- W Dulinski
- W Enning
- W Glatte
- W Grimme
- W Haubold
- W Haubold
- W Herz
- W Hubis
- W Jonghe De
- W Jost
- W Kabaivanov
- W Katz
- W Kern
- W Langenbeck
- W Laves
- W Linne
- W Machle
- W Meine
- W Mielenz
- W Niklowitz
- W Schlenk
- W Strohmeier
- W Strohmeier
- W Strohmeier
- W Ulrich
- W Wirth
- WA Aue
- WA Aue
- WA Aue
- WA Brown
- WA Brown
- WA Nugent
- WA Nugent
- WA Partridge
- WA Schulze
- WB Engelbrecht
- WD Good
- WD Good
- WD Good
- WD Good
- WD Good
- WD Harkins
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- WE Becker
- WE Catlin
- WE Morris
- WE Morris
- WE Vaughan
- WF Anzilotti
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Machle
- WF Schmidt
- WF Schoen
- WG Agnew
- WH Charch
- WH Howell
- WH Hubner
- WH Thomas
- WH Thomas
- WH Thomas
- WH Zartman
- WI Throw
- WI Throw
- WI Zang
- WIL Throw
- WJ Mitchell
- WJ Niklowitz
- WJ Niklowitz
- WJ Niklowitz
- WJ Pitz
- WJ Settineri
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WN Ipatiew
- WN Ipatiew
- WN Ipatiew
- WR Law
- WR Ormandy
- WR Wade
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRF Notten
- WS Levine
- WT Lyn
- WT Sturges
- WV Steele
- WW Parker
- WW Parker
- WW Parker
- WW Woessner
- X Liebl
- X Xiaoding
- X Xiaoding
- X Xiaoding
- Y Aleksandrov
- Y Kaneko
- Y Marumo
- Y Mayor
- Y Miah
- Y Miah
- Y Mizoi
- Y Sayato
- Y Shao
- Y Ta
- Y Ta
- Y Ta
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Vasilenko
- Y Wakuri
- Y Yamamoto
- Y Yamamura
- Y Yamamura
- Y Yamamura
- Y Yonekawa
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Alexandrov
- YA Alexandrov
- YD Semchikov
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YM Zinov’ev
- YM Zinov’ev
- YS Drugov
- YV Zhigailo
- Z Aneva
- Z Drabent
- Z Drabent
- Z Drabent
- Z Florjanczyk
- Z Forycki
- Z Karny
- Z Kowalski
- Z Kozarzewska
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- ZK Lynkina
- ZM Manulkin
- ZM Manulkin
- ZM Manulkin
- ZM Manulkin
- ZV Veksler
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study