Myc proteins in brain tumor development and maintenance

Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies

Prevalence of oral lesions among Saudi dental patients

<b>Background and Objectives:</b> Few studies have been conducted in the Saudi population on oral mucosal lesions. The purpose of this study was to evaluate the type and extent of oral lesions in a study among dental patients at a college of dentistry in Saudi Arabia. <b> Patients and Methods:</b> Over a 3-year period, 2552 dental outpatients were interviewed and investigated clinically for the presence of oral mucosal conditions. A thorough oral clinical examination was performed, including a radiographic examination. The diagnosis was confirmed histopathologically when necessary. <b> Results: </b> Of 383 (15.0&#x0025;) patients found to have oral mucosal lesions, females constituted 57.7&#x0025; (n=221) and males 42.3&#x0025; (n=162). The age range of the patients was between 15 to 73 years with a mean age of 38.2 years. The most commonly affected age group was 31 to 40 years, which comprised 21.4&#x0025; (n=82) of all affected individuals. The least affected age group were individuals older than 61 years. The most common lesion was Fordyce granules (3.8&#x0025;; n=98), followed by leukoedema (3.4&#x0025;; n=86) and traumatic lesions (ulcer, erosion) in 1.9&#x0025; (n=48). Tongue abnormalities were present in 4.0&#x0025; (n=101) of all oral conditions observed, ranging from 1.4&#x0025; (n=36) for fissured tongue to 0.1&#x0025; (n=2) for bifid tongue. Other findings detected were torous platinus (1.3&#x0025;; n=34), mandibular tori (0.1&#x0025;; n=2) aphthous ulcer (0.4&#x0025;; n=10), herpes simplex (0.3&#x0025;; n=7), frictional hyperkeratosis (0.9&#x0025;; n=23), melanosis (0.6&#x0025;; n=14), lichen planus (0.3&#x0025;; n=9) and nicotinic stomatitis (0.5&#x0025;; n=13). <b>Conclusion: </b> The findings of this study provide information on the types and prevalence of oral lesions among Saudi dental patients. This provides baseline data for future studies about the prevalence of oral lesions in the general population