I beni comuni tra categorie romanistiche e dibattiti vecchi e nuovi

The article, after having reconstructed some lines of the international and Italian debate on commons and their legal discipline, examines in the light of the Roman sources the attempt to indicate in the Roman categories of goods removed from individual ownership possible models for the regulation of commons. Finally, two examples taken from medieval and modern history will be taken in consideration, which show how recourse to Roman categories of goods to model the discipline of current phenomena is an operation to be carried out with caution

Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire

Objectives The primary objective of this study was the translation and validation of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire into Italian, denoted as AAV-PRO_ita. The secondary objective was to evaluate the impact of ANCA-associated vasculitis (AAV) on quality of life (QoL) and work impairment in a large cohort of Italian patients. Methods The study design took a prospective cohort study approach. First, the AAV-PRO was translated into Italian following the step guidelines for translations. The new AAV-PRO_ita questionnaire covered three disease domains: organ-specific and systemic symptoms and signs; physical function; and social and emotional impact. Second, Italian-speaking AAV patients were recruited from 17 Italian centres belonging to the Italian Vasculitis Study Group. Participants completed the AAV-PRO_ita questionnaire at three time points. Participants were also requested to complete the work productivity and activity impairment: general health questionnaire. Results A total of 276 AAV patients (56.5% women) completed the questionnaires. The AAV-PRO_ita questionnaire demonstrated a good internal consistency and test-retest reliability. Female AAV patients scored higher (i.e. worse) in all thee domains, especially in the social and emotional impact domain (P < 0.001). Patients on glucocorticoid therapy (n = 199) had higher scores in all domains, especially in the physical function domain (P < 0.001), compared with patients not on glucocorticoid therapy (n = 77). Furthermore, patients who had at least one relapse of disease (n = 114) had higher scores compared with those who had never had one (n = 161) in any domain (P < 0.05). Finally, nearly 30% of the patients reported work impairment. Conclusion The AAV-PRO_ita questionnaire is a new 29-item, disease-specific patient-reported outcome measuring tool that can be used in AAV research in the Italian language. Sex, glucocorticoids and relapsing disease showed the greatest impact on QoL

Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study.

OBJECTIVE: Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported studies, successful real-life experiences with the approved dose for treating severe eosinophilic asthma (100 mg every 4 weeks) were observed. We undertook this study to assess the effectiveness and safety of mepolizumab 100 mg every 4 weeks and 300 mg every 4 weeks in a large European EGPA cohort. METHODS: We included all patients with EGPA treated with mepolizumab at the recruiting centers in 2015-2020. Treatment response was evaluated from 3 months to 24 months after initiation of mepolizumab. Complete response to treatment was defined as no disease activity (Birmingham Vasculitis Activity Score [BVAS] = 0) and a prednisolone or prednisone dose (or equivalent) of ≤4 mg/day. Respiratory outcomes included asthma and ear, nose, and throat (ENT) exacerbations. RESULTS: Two hundred three patients, of whom 191 received a stable dose of mepolizumab (158 received 100 mg every 4 weeks and 33 received 300 mg every 4 weeks) were included. Twenty-five patients (12.3%) had a complete response to treatment at 3 months. Complete response rates increased to 30.4% and 35.7% at 12 months and 24 months, respectively, and rates were comparable between mepolizumab 100 mg every 4 weeks and 300 mg every 4 weeks. Mepolizumab led to a significant reduction in BVAS score, prednisone dose, and eosinophil counts from 3 months to 24 months, with no significant differences observed between 100 mg every 4 weeks and 300 mg every 4 weeks. Eighty-two patients (40.4%) experienced asthma exacerbations (57 of 158 [36%] who received 100 mg every 4 weeks; 17 of 33 [52%] who received 300 mg every 4 weeks), and 31 patients (15.3%) experienced ENT exacerbations. Forty-four patients (21.7%) experienced adverse events (AEs), most of which were nonserious AEs (38 of 44). CONCLUSION: Mepolizumab at both 100 mg every 4 weeks and 300 mg every 4 weeks is effective for the treatment of EGPA. The 2 doses should be compared in the setting of a controlled trial

La legislazione pubblicistica di Giustiniano tra il 534 e il 535. Note minime sull’attività della cancelleria imperiale

Tra l’aprile del 534 e lo stesso mese del 535 Giustiniano emana una serie di provvedimenti volti a riformare alcuni aspetti dell’amministrazione ‘periferica’ dell’impero: due costituzioni volte a riorganizzare la prefettura d’Africa, emanate nel 534 ed inserite nel Codex repetitae praelectionis (C.I. 1,27), e due leges ‘generali’ volte a reprimere la pratica del suffragium (Nov. 8) e ripristinare quella dei mandata principum (Nov. 17). La dottrina più recente mostra di considerare unitariamente questi interventi come parti di un coerente piano di ristrutturazione istituzionale, proseguito poi con la riforma delle singole unità territoriali negli anni seguenti, complessivamente ispirato agli ideali della reverentia antiquitatis e della restaurazione dell’ordine romano. Secondo l’Autore, però, alcune osservazioni circa contenuto e formazione di quei provvedimenti restituiscono un quadro più frastagliato dell’attività della cancelleria in quel momento di trapasso dalle grandi compilazioni (Digesta e Codex) alla legislazione novellare, e suggeriscono quindi di accogliere questa ricostruzione dei caratteri della legislazione pubblicistica di Giustiniano con talune cautele

USUS PUBLICUS: tutela interdittale e classificazione delle cose

La presente indagine rappresenta il tentativo di mettere a fuoco la nozione di usus publicus emergente dalla lettura delle fonti romane in tema di tutela interdittale di taluni beni pubblici chiamati perciò nelle fonti,perlomeno a partire dall'età augustea, res in usu publico

ANALISI ECONOMICA DEL DIRITTO ROMANO DEI BENI PUBBLICI: L’ESEMPIO DI FIUMI E STRADE

Il contributo mira a fornire una lettura delle fonti romane in tema di res in usu publico alla luce della teoria dei property rights. La prima parte ricostruisce il reciproco avvicinamento di analisi economica e storia del diritto, specialmente nello studio dei cosiddetti commons. Nella seconda parte si richiamano alcuni concetti fondamentali della teoria dei property rights in particolare con riferimento ai public goods. Nella terza parte si rileggono alcune fonti relativi agli interdetti a tutela delle res in publico alla luce dell'impostazione prospettata

Acqua e diritto romano: "invenzione" di un modello?

Il paper affronta il problema delle condizioni di configurabilità dell'acqua come bene dotato di una disciplina autonoma, nelle fonti romane e nella tradizione romanistica

Commento ai testi 5 e 6

Commento ai testi 5 e 6 del volum

Review of Carlo Pelloso: Democracies and Republics Between Past and Future: From the Athenian Agora to e-Democracy, from the Roman Republic to Negative Power

Prendendo spunto dalla pubblicazione di un saggio di Carlo Pelloso si inquadrano alcuni snodi fondamentali del rapporto tra pensiero politico moderno e fonti ed esempi dell'antichità classica

Commento al testo 29

Commento al testo 29 del volume