Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701–negative recipients

Radiative corrections in bumblebee electrodynamics

We investigate some quantum features of the bumblebee electrodynamics in flat spacetimes. The bumblebee field is a vector field that leads to a spontaneous Lorentz symmetry breaking. For a smooth quadratic potential, the massless excitation (Nambu-Goldstone boson) can be identified as the photon, transversal to the vacuum expectation value of the bumblebee field. Besides, there is a massive excitation associated with the longitudinal mode and whose presence leads to instability in the spectrum of the theory. By using the principal-value prescription, we show that no one-loop radiative corrections to the mass term is generated. Moreover, the bumblebee self-energy is not transverse, showing that the propagation of the longitudinal mode can not be excluded from the effective theory.Comment: Revised version: contains some more elaborated interpretation of the results. Conclusions improve

Nonminimal Maxwell-Chern-Simons-O(3)-sigma vortices: asymmetric potential case

In this work we study a nonlinear gauged O(3)-sigma model with both minimal and nonminimal coupling in the covariant derivative. Using an asymmetric scalar potential, the model is found to exhibit both topological and non-topological soliton solutions in the Bogomol'nyi limit.Comment: 4 pages, 4 figures. Some typos corrected, two references changed. To appear in Physical Review

Gauge fields in a string-cigar braneworld

In this work we investigate the properties of an Abelian gauge vector field in a thin and in a smoothed string-like braneworld, the so-called string-cigar model. This thick brane scenario satisfies the regularity conditions and it can be regarded as an interior and exterior string-like solution. The source undergoes a geometric Ricci flow which is connected to a variation of the bulk cosmological constant. The Ricci flow changes the width and amplitude of the massless mode at the brane core and recover the usual thin string-like behavior at large distances. By numerical means we obtain the Kaluza-Klein (KK) spectrum for both the thin brane and the string-cigar. It turns out that both models exhibit a mass gap between the massless and the massive modes and between the high and the low mass regimes. The KK modes are smooth near the brane and their amplitude are enhanced by the string-cigar core. The analogue Schr\"odinger potential is also tuned by the geometric flow.Comment: The discussion about the Kaluza-Klein spectrum of the gauge field was improved. Numerical analysis was adapted to the conventional notation on Kaluza-Klein number. Some graphics were modified for considering other notation. Results unchanged. References added. Corrected typos. 17 pages. 6 figures. To match version to appears in Physics Letters