Prototipo para levantamiento arquitectónico: Desarrollo y evaluación caso de estudio del Hospital Metropolitano de Tunja

This article describes the development and implementation of a compact and portable prototype for the survey of a point cloud of the Metropolitan Hospital of Tunja, Colombia, as a result of the SENNOVA project called “Development of preliminary diagnoses in existing buildings from the merger of 4 remote sensing technologies: laser scanner, photogrammetry, thermography and ground penetrating radar, through information models (BIM)”, developed by the collaboration of the Industrial Center for Maintenance and Manufacturing (Sena Regional Boyacá). Key components of this solution include a Hesai lidar, a 9-axis inertial unit (IMU), and a UP4000 computer. The construction of the point cloud was carried out through the implementation of LIO-SAM, which is developed in the ROS framework.Data acquisition was performed in three different configurations of the LIDAR and the IMU. This approach sought to determine the most effective orientation to achieve a complete and accurate representation. Simultaneously, tests were carried out by modifying the closed loop parameter in LIO-SAM and running the software on both the UP4000 and an external computer.The results revealed that the configuration that minimizes the error is achieved by positioning the LIDAR and IMU horizontally, with the Z axis oriented vertically. However, the need for additional tests to comprehensively evaluate the influence of the closed-loop parameter was highlighted. In addition, it was observed that the UP4000 has sufficient processing capacity to execute LIO-SAM, although the simultaneous execution of more processes could affect the results obtained.El presente articulo describe la construcción e´ implementación de un prototipo compacto y portátil para el levantamiento de una nube de puntos del Hospital Metropolitano de Tunja, Colombia, como resultado del proyecto SENNOVA denominado “Desarrollo de diagnósticos preliminares en edificaciones existentes a partir de la fusión de 4 tecnologías de sensoramiento remoto: escáner láser, fotogrametría, termografía y radar de penetración de terrenos, a través de modelos de información (BIM)”, desarrollado en conjunto con el Centro Industrial de Mantenimiento y Manufactura (Sena Regional Boyacá). Los componentes clave de esta solución  incluyen un LIDAR Hesai, una unidad inercial de 9 ejes (IMU) y una computadora UP4000. La construcción de la nube de puntos´ se llevó a cabo mediante la implementación de LIO-SAM, el cual se encuentra desarrollado en el marco de ROS. La adquisición de datos fue realizada en tres configuraciones distintas del LIDAR y la IMU. Este enfoque buscaba determinar la orientación  más efectiva para lograr una representación completa y precisa. Simultáneamente, se llevaron a cabo pruebas´ modificando el parámetro de lazo cerrado en LIO-SAM y ejecutando el software tanto en la UP4000 como en un computador externo. Los resultados revelaron que la configuración que minimiza el error se logra al posicionar el LIDAR y la IMU horizontalmente, con el eje Z orientado verticalmente. No obstante, se destacó la necesidad de realizar pruebas adicionales para evaluar exhaustivamente la influencia del parámetro de lazo cerrado. Además, se observó o que la UP4000 posee suficiente capacidad de procesamiento para ejecutar LIO-SAM, aunque la ejecución simultanea de más procesos podría afectar los resultados obtenidos

Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort studyResearch in context

Summary: Background: The clinical relevance of recurrent venous thromboembolism (VTE) after discontinuing anticoagulation in patients with COVID-19-associated VTE remains uncertain. We estimated the incidence rates and mortality of VTE recurrences developing after discontinuing anticoagulation in patients with COVID-19-associated VTE. Methods: A prospective, multicenter, non-interventional study was conducted between March 25, 2020, and July 26, 2023, including patients who had discontinued anticoagulation after at least 3 months of therapy. All patients from the registry were analyzed during the study period to verify inclusion criteria. Patients with superficial vein thrombosis, those who did not receive at least 3 months of anticoagulant therapy, and those who were followed for less than 15 days after discontinuing anticoagulation were excluded. Outcomes were: 1) Incidence rates of symptomatic VTE recurrences, and 2) fatal PE. The rate of VTE recurrences was defined as the number of patients with recurrent VTE divided by the patient-years at risk of recurrent VTE during the period when anticoagulation was discontinued. Findings: Among 1106 patients with COVID-19-associated VTE (age 62.3 ± 14.4 years; 62.9% male) followed-up for 12.5 months (p25-75, 6.3–20.1) after discontinuing anticoagulation, there were 38 VTE recurrences (3.5%, 95% confidence interval [CI]: 2.5–4.7%), with a rate of 3.1 per 100 patient-years (95% CI: 2.2–4.2). No patient died of recurrent PE (0%, 95% CI: 0–7.6%). Subgroup analyses showed that patients with diagnosis in 2021–2022 (vs. 2020) (Hazard ratio [HR] 2.86; 95% CI 1.45–5.68) or those with isolated deep vein thrombosis (vs. pulmonary embolism) (HR 2.31; 95% CI 1.19–4.49) had significantly higher rates of VTE recurrences. Interpretation: In patients with COVID-19-associated VTE who discontinued anticoagulation after at least 3 months of treatment, the incidence rate of recurrent VTE and the case-fatality rate was low. Therefore, it conceivable that long-term anticoagulation may not be required for many patients with COVID-19-associated VTE, although further research is needed to confirm these findings. Funding: Sanofi and Rovi, Sanofi Spain

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present