Consistency of WIMP Dark Matter as radiative neutrino mass messenger

The scotogenic scenario provides an attractive approach to both Dark Matter and neutrino mass generation, in which the same symmetry that stabilises Dark Matter also ensures the radiative seesaw origin of neutrino mass. However the simplest scenario may suffer from inconsistencies arising from the spontaneous breaking of the underlying $\mathbb{Z}_2$ symmetry. Here we show that the singlet-triplet extension of the simplest model naturally avoids this problem due to the presence of scalar triplets neutral under the $\mathbb{Z}_2$ which affect the evolution of the couplings in the scalar sector. The scenario offers good prospects for direct WIMP Dark Matter detection through the nuclear recoil method.Comment: 16 pages, 7 figure

Associations of cow and farm characteristics with cow-level lameness using data from an extensive cross-sectional study across 3 structurally different dairy regions in Germany

The aim of the present study was to evaluate the associations between milk recording data, body condition score (BCS), housing factors, management factors, and lameness in freestall-housed dairy cows in 3 structurally different regions in Germany. These regions substantially vary regarding herd size, breeds, access to pasture, farm management (family run or company owned), and percentage of organic farms. The data used was collected in a large cross-sectional study from 2016 to 2019. A total of 58,144 cows from 651 farms in 3 regions of Germany (North, East, and South) was scored for locomotion and body condition. Additionally, data on milk yield, milk composition, breed, age, as well as information on housing and management were retrieved. One mixed-logistic regression model was fitted per region to evaluate the association of the data with the target variable “lame” and to allow for a comprehensive reflection across different kinds of farming types. In all regions, undercondition (BCS lower than recommended for the lactation stage; North: odds ratio [OR] 2.15, CI 1.96–2.34; East: OR 2.66, CI 2.45–2.88; South: OR 2.45, CI 2.01–2.98) and mid-lactation stage (102–204 d in milk; North: OR 1.15, CI 1.05–1.27; East: OR 1.24, CI 1.17–1.32; South: OR 1.38, CI 1.18–1.62) were associated with higher odds for lameness, whereas overcondition (BCS higher than recommended for the lactation stage; North: OR 0.51, CI 0.44–0.60; East: OR 0.51, CI 0.48–0.54; South: OR 0.65, CI 0.54–0.77) and parity of 1 or 2 was associated with lower odds (parity 1 = North: OR 0.32, CI 0.29–0.35; East: OR 0.19, CI 0.18–0.20; South: OR 0.28, CI 0.24–0.33; parity 2 = North: OR 0.51, CI 0.47–0.46; East: OR 0.41, CI 0.39–0.44; South: OR 0.49, CI 0.42–0.57), irrespective of the regional production characteristics. Low energy-corrected milk yield was associated with higher odds for lameness in South and North (North: OR 1.16, CI 1.05–1.27; South: OR 1.43, CI 1.22–1.69). Further factors such as pasture access for cows (North: OR 0.64, CI 0.50–0.82; and South: OR 0.65, CI 0.47–0.88), milk protein content (high milk protein content = North: OR 1.34, CI 1.18–1.52; East: OR 1.17, CI 1.08–1.28; low milk protein content = North: OR 0.79, CI 0.71–0.88; East: OR 0.84, CI 0.79–0.90), and breed (lower odds for “other” [other breeds than German Simmental and German Holstein] in East [OR 0.47, CI 0.42–0.53] and lower odds both for German Holstein and “other” in South [German Holstein: OR 0.62, CI 0.43–0.90; other: OR 0.46, CI 0.34 – 0.62]) were associated with lameness in 2 regions, respectively. The risk of ketosis (higher odds in North: OR 1.11, CI 1.01–1.22) and somatic cell count (higher odds in East: increased (>39.9 cells × 1,000/mL): OR 1.10; CI 1.03–1.17; high (>198.5 cells × 1,000/mL): OR 1.08; CI 1.01–1.06) altered the odds for lameness in 1 region, respectively. Cows from organic farms had lower odds for lameness in all 3 regions (North: OR 0.18, CI 0.11–0.32; East: OR 0.39, CI 0.28–0.56; South: OR 0.45, CI 0.29–0.68). As the dairy production systems differed substantially between the different regions, the results of this study can be viewed as representative for a wide variety of loose-housed dairy systems in Europe and North America. The consistent association between low BCS and lameness in all regions aligns with the previous literature. Our study also suggests that risk factors for lameness can differ between geographically regions, potentially due to differences in which dairy production system is predominantly used and that region-specific characteristics should be taken into account in comparable future projects

The relationship between lameness prevalence and pasture access in 659 dairy herds in Germany

Lameness in dairy cows is an expression of pain most likely originating from a claw disorder, causing impaired animal wellbeing and substantial economic losses for farmers. The aim of this study was to investigate the effects of access to pasture, time spent on pasture, and season on farm level lameness prevalence. The survey was part of a cross-sectional observational study, in which farms in three regions of Germany (North, East and South) were visited by study veterinarians. On each farm (total: 659, N: 240, E: 247, S: 172), management data were recorded, and cows were scored for locomotion, according to Sprecher. Median farm-level lameness prevalence (Score 3/5 or higher) was 29.4% (IQR: 18.7% - 42.0%), and 8.2% (IQR: 3.7% - 14.0%) for severe lameness (Score 4/5 or higher). Farm-level lameness prevalence continuously decreased with increasing time spent on pasture (up to approximately 10 hours per cow per day). On farms that did not offer their cows access to pasture lameness prevalence did not show a seasonal variation. On farms where cows had pasture access for up to three hours per day lameness prevalence peaked in autumn. In contrast, on farms offering their cows access to pasture beyond three hours per day the peak of lameness was observed in spring. Our results revealed that even short periods of pasture access of at least two hours per cow and day (on average per year) are beneficial for the locomotion of dairy cows

Constraining New Physics with a Positive or Negative Signal of Neutrino-less Double Beta Decay

We investigate numerically how accurately one could constrain the strengths of different short-range contributions to neutrino-less double beta decay in effective field theory. Depending on the outcome of near-future experiments yielding information on the neutrino masses, the corresponding bounds or estimates can be stronger or weaker. A particularly interesting case, resulting in strong bounds, would be a positive signal of neutrino-less double beta decay that is consistent with complementary information from neutrino oscillation experiments, kinematical determinations of the neutrino mass, and measurements of the sum of light neutrino masses from cosmological observations. The keys to more robust bounds are improvements of the knowledge of the nuclear physics involved and a better experimental accuracy.Comment: 23 pages, 3 figures. Minor changes. Matches version published in JHE

Some Aspects of Soviet Education

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68955/2/10.1177_002248716001100420.pd

Solitary waves in the Nonlinear Dirac Equation

In the present work, we consider the existence, stability, and dynamics of solitary waves in the nonlinear Dirac equation. We start by introducing the Soler model of self-interacting spinors, and discuss its localized waveforms in one, two, and three spatial dimensions and the equations they satisfy. We present the associated explicit solutions in one dimension and numerically obtain their analogues in higher dimensions. The stability is subsequently discussed from a theoretical perspective and then complemented with numerical computations. Finally, the dynamics of the solutions is explored and compared to its non-relativistic analogue, which is the nonlinear Schr{\"o}dinger equation. A few special topics are also explored, including the discrete variant of the nonlinear Dirac equation and its solitary wave properties, as well as the PT-symmetric variant of the model

Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease

OBJECTIVES: Higher-educated patients with Alzheimer disease (AD) can harbor greater neuropathologic burden than those with less education despite similar symptom severity. In this study, we assessed whether this observation is also present in potential preclinical AD stages, namely in individuals with subjective cognitive decline and clinical features increasing AD likelihood (SCD+). METHODS: Amyloid-PET information ([18F]Flutemetamol or [18F]Florbetaben) of individuals with SCD+, mild cognitive impairment (MCI), and AD were retrieved from the AMYPAD-DPMS cohort, a multicenter randomized controlled study. Group classification was based on the recommendations by the SCD-I and NIA-AA working groups. Amyloid PET images were acquired within 8 months after initial screening and processed with AMYPYPE. Amyloid load was based on global Centiloid (CL) values. Educational level was indexed by formal schooling and subsequent higher education in years. Using linear regression analysis, the main effect of education on CL values was tested across the entire cohort, followed by the assessment of an education-by-diagnostic-group interaction (covariates: age, sex, and recruiting memory clinic). To account for influences of non-AD pathology and comorbidities concerning the tested amyloid-education association, we compared white matter hyperintensity (WMH) severity, cardiovascular events, depression, and anxiety history between lower-educated and higher-educated groups within each diagnostic category using the Fisher exact test or χ2 test. Education groups were defined using a median split on education (Md = 13 years) in a subsample of the initial cohort, for whom this information was available. RESULTS: Across the cohort of 212 individuals with SCD+ (M(Age) = 69.17 years, F 42.45%), 258 individuals with MCI (M(Age) = 72.93, F 43.80%), and 195 individuals with dementia (M(Age) = 74.07, F 48.72%), no main effect of education (ß = 0.52, 95% CI -0.30 to 1.58), but a significant education-by-group interaction on CL values, was found (p = 0.024) using linear regression modeling. This interaction was driven by a negative association of education and CL values in the SCD+ group (ß = -0.11, 95% CI -4.85 to -0.21) and a positive association in the MCI group (ß = 0.15, 95% CI 0.79-5.22). No education-dependent differences in terms of WMH severity and comorbidities were found in the subsample (100 cases with SCD+, 97 cases with MCI, 72 cases with dementia). DISCUSSION: Education may represent a factor oppositely modulating subjective awareness in preclinical stages and objective severity of ongoing neuropathologic processes in clinical stages

The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population: a comparison of two German registries

Objectives: To investigate, whether inflammatory rheumatic diseases (IRD) inpatients are at higher risk to develop a severe course of SARS-CoV-2 infections compared to the general population, data from the German COVID-19 registry for IRD patients and data from the Lean European Survey on SARS-CoV-2 (LEOSS) infected patients covering inpatients from the general population with SARS-CoV-2 infections were compared. Methods: 4310 (LEOSS registry) and 1139 cases (IRD registry) were collected in general. Data were matched for age and gender. From both registries, 732 matched inpatients (LEOSS registry: n = 366 and IRD registry: n = 366) were included for analyses in total. Results: Regarding the COVID-19 associated lethality, no significant difference between both registries was observed. Age > 65°years, chronic obstructive pulmonary disease, diabetes mellitus, rheumatoid arthritis, spondyloarthritis and the use of rituximab were associated with more severe courses of COVID-19. Female gender and the use of tumor necrosis factor-alpha inhibitors (TNF-I) were associated with a better outcome of COVID-19. Conclusion: Inflammatory rheumatic diseases (IRD) patients have the same risk factors for severe COVID-19 regarding comorbidities compared to the general population without any immune-mediated disease or immunomodulation. The use of rituximab was associated with an increased risk for severe COVID-19. On the other hand, the use of TNF-I was associated with less severe COVID-19 compared to the general population, which might indicate a protective effect of TNF-I against severe COVID-19 disease

Running of Radiative Neutrino Masses: The Scotogenic Model

We study the renormalization group equations of Ma's scotogenic model, which generates an active neutrino mass at 1-loop level. In addition to other benefits, the main advantage of the mechanism exploited in this model is to lead to a natural loop-suppression of the neutrino mass, and therefore to an explanation for its smallness. However, since the structure of the neutrino mass matrix is altered compared to the ordinary type I seesaw case, the corresponding running is altered as well. We have derived the full set of renormalization group equations for the scotogenic model which, to our knowledge, had not been presented previously in the literature. This set of equations reflects some interesting structural properties of the model, and it is an illustrative example for how the running of neutrino parameters in radiative models is modified compared to models with tree-level mass generation. We also study a simplified numerical example to illustrate some general tendencies of the running. Interestingly, the structure of the RGEs can be exploited such that a bimaximal leptonic mixing pattern at the high-energy scale is translated into a valid mixing pattern at low energies, featuring a large value of \theta_{13}. This suggests very interesting connections to flavour symmetries.Comment: 35 pages, 10 figures, 2 table