Ukupni i specifični mortalitet u radnika izloženih azbestu od 1907. do 1985. godine

Total and cause-specific mortality data for the 1907 -1985 period were compared between cohorts of male asbestos-cement workers (N = 1908) and referents (N = 726), using Poisson regression modelling. The rate ratio (RR) for total mortality was significantly increased (1.3) among the exposed workers, as was mortality from non-malignant respiratory disease (RR= 2.2). Numerically, but not statistically significantly, raised ratios were found for respiratory (RR= 1.6) and gastrointestinal (RR= 1.3) cancers. The trend in the rate ratio for total mortality with time was better fitted with a curved line, than with a monotonic one, because of a period of increased risk up to the 1950s, and another one starting after 1970.Ukupni i specifični mortalitet za razdoblje od 1907. do 1985. godine uspoređen je u kohortama muških radnika koji su bili izloženi azbestu (N = 1908) s kontrolama (N = 726) pomoću Poissonove regresijske analize. Koeficijent regresije (RR) za ukupni mortalitet, kao i mortalitet od nemalignih respiratornih bolesti bio je statistički značajno viši i iznosio je 1,3, odnosno 2,2. Povećanje ovog koeficijenta nađeno je i za plućni (1,6) i gastrointestinalni karcinom (1,3), ali vrijednosti nisu statistički značajne

Inverse problem by Cauchy data on arbitrary subboundary for system of elliptic equations

We consider an inverse problem of determining coefficient matrices in an $N$-system of second-order elliptic equations in a bounded two dimensional domain by a set of Cauchy data on arbitrary subboundary. The main result of the article is as follows: If two systems of elliptic operators generate the same set of partial Cauchy data on an arbitrary subboundary, then the coefficient matrices of the first-order and zero-order terms satisfy the prescribed system of first-order partial differential equations. The main result implies the uniqueness of any two coefficient matrices provided that the one remaining matrix among the three coefficient matrices is known

A local families index formula for d-bar operators on punctured Riemann surfaces

Using heat kernel methods developed by Vaillant, a local index formula is obtained for families of d-bar operators on the Teichmuller universal curve of Riemann surfaces of genus g with n punctures. The formula also holds on the moduli space M{g,n} in the sense of orbifolds where it can be written in terms of Mumford-Morita-Miller classes. The degree two part of the formula gives the curvature of the corresponding determinant line bundle equipped with the Quillen connection, a result originally obtained by Takhtajan and Zograf.Comment: 47 page

(−)‐[ 18 F]Flubatine: evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101867/1/jlcr3069.pd

Inhibitory and excitatory amino acid neurotransmitter binding sites in cynomolgus monkey (Macaca fascicularis) cervical spinal cord

Autoradiography of inhibitory and excitatory amino acid neurotransmitter binding sites in the cervical spinal cord of M. fascicularis spinal cord revealed inhomogenous distribution of all binding sites in spinal gray matter. Quisqualate-sensitive [3H]glutamate binding, [3H]MK-801 binding, benzodiazepine binding, kainate binding, and GABAB binding had highest levels in the superficial layers of the dorsal horn (laminae 1 and 2) and substantially lower levels in other laminae. [3H]Strychnine binding was more uniformly distributed throughout all laminae with highest levels in the superficial layers of the dorsal horn. These results are similar to those found in other mammals.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30961/1/0000633.pd

Implied volatility of basket options at extreme strikes

In the paper, we characterize the asymptotic behavior of the implied volatility of a basket call option at large and small strikes in a variety of settings with increasing generality. First, we obtain an asymptotic formula with an error bound for the left wing of the implied volatility, under the assumption that the dynamics of asset prices are described by the multidimensional Black-Scholes model. Next, we find the leading term of asymptotics of the implied volatility in the case where the asset prices follow the multidimensional Black-Scholes model with time change by an independent increasing stochastic process. Finally, we deal with a general situation in which the dependence between the assets is described by a given copula function. In this setting, we obtain a model-free tail-wing formula that links the implied volatility to a special characteristic of the copula called the weak lower tail dependence function

Chronic intrastriatal quinolinic acid produces reversible changes in perikaryal calbindin and parvalbumin immunoreactivity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31558/1/0000485.pd

Mineralna vlakna, fibroza i azbestna tjelešca u plućnom tkivu radnika koji su bili izloženi azbestnom cementu

Samples of lung tissue taken from deceased asbestos-cement workers, with (N = 7) and without (N = 69) mesothelioma, and from individually matched controls (N = 96) were examined. The number of asbestos bodies and the grade of fibrosis were determined with light microscopy, and the type, size, and number of fibres with transmission electron microscopy and energy dispersive X-ray spectrometry. The asbestos content was, as expected, higher among the exposed workers than among the controls. Chrysotile was the major fibre type in terms of fibre count. Conversion to fibre mass reversed the pattern to a predominance of amphibole fibres, and accentuated the differences between exposed workers and controls. Duration of exposure and the number of asbestos bodies displayed significant associations with all the singular amphiboles (amosite, crocidolite, tremolite, and anthophyllite), but not with chrysotile. Fibrosis was related to the tremolite content, but not to chrysotile, both among exposed workers and controls. The workers with mesothelioma had higher levels of crocidolite and tremolite than the other asbestos-cement workers.Ispitivani su uzorci plućnog tkiva umrlih radnika koji su bili izloženi azbestnom cementu, s mezoteliomom, i bez njega, i njihovim odgovarajućim kontrolama. Broj azbestnih tjelešaca i stupanj fibroze određeni su svjetlosnim mikroskopom, a tip, veličina i broj vlakana elektronskom mikroskopijom i rendgenskom spektrometrijom. Sadržaj azbesta bio je veći kod izloženih radnika negoli u kontrola. Krizotilna vlakna bila su najbrojnija među formiranim vlaknima. Nađena je da je duljina izloženosti i broj azbestnih tjelešaca u korelaciji sa svim pojedinačnim amfolitima (amozit, krocidolit, tremolit i antofilit), ali ne i s krizotilom. Nalaz fibroze bio je u korelaciji s tremolitom, za razliku od krizolita, i to u eksponiranih i kontrolnih radnika. Uzorci plućnog tkiva radnika s mezoteliomom sadržavali su više krocidolita i tremolita od drugih radnika koji su bili izloženi azbestnom cementu