Synthesis and Characterization of Complexes of Schiff Base [1, 2-Diphenyl -2- 2-{[1-(3-Amino-Phenyl)-Ethylidene]-Hydrazono Methyl}-Phenol] with Mn(II), Fe(II), Co(II), Cu(II), Zn(II), Cd(II), Ni(II), and Hg(II) Ions

The new tridentate Schiff base ligand (HL)namely 2-{[1-(3-amino-phenyl)-ethylidene]-hydrazono methyl}-phenol containing (N N O)as donors atoms  was prepared in two steps:Step (1): By the reaction of 3-aminoacetophenone with hydrazine monohydrate under reflux in methanol and drops of glacial acetic acid gave the intermediate compound 3-(1- hydrazono ethyl)-phenol amine.Step (2): By the reaction of 3-(1-hydrazono ethyl)-phenol amine with salicyaldehyde under reflux in methanol, gave the ligand (HL).The prepared ligand was characterized by I.R, U.V-Vis,1H- 13C NMR spectra and melting point and reacted with some metal ions under reflux in methanol with (1:1) ratio gave complexes of the general formula: [MClL]. Where: M= Mn(II), Fe(II), Co(II), Cu(II), Zn(II), Cd(II), Ni(II), and Hg(II).Products were found to be solid crystalline complexes, which have been characterized through the following techniques:Molar conductivity .Spectroscopic Method [FTIR and UV-Vis], additional measurement magnetic suspeliblity and  Chloride  content, The magnetic moment coupled with the electronic spectra suggested an  tetrahedral geometry for all the complexes except[ NiClL] is Square-planar.The nature of the complexes formed were studied by Mole Ratio and  the stability constant of the complexes have also been studied. Key words: spectral studies , tridentate Schiff base, 3-aminoacetophenone, hydrazine monohydrate complexe

Synthesis and Characterization of Gelatin-G-Poly (Acryloyl Amide) Proflavine and Controlled Release Study

Gelatin-grafted N- proflavine acryl amide was synthesized through two steps; firstly the Gelatin was grafted with acrylic acid free radically using Ammonium per-sulfate at 60?, Then it was modified to its corresponding acyl chloride derivation, second step included the substitution with amino group of proflavine, in this research Gelatin was used as a natural nontoxic,   water soluble polymer as a drug carrier. The prepared pro drug polymer was characterized by FTIR and 1H-NMR spectroscopies, Controlled drug release was studied in different pH values at 37?. Many advantages were obtained comparing with other known methods. Keywords: Gelatin, Acrylic acid, Proflavine and Gelatin,.and pro-drug polyme

Synthesis, Characterization, and Antibacterial Studies of Mn (II) , Fe (II) , Co(II) , Ni(II), Cu (II) and Cd(II) Mixed- Ligand Complexes Containing Amino Acid ( L-Valine) And (1,10- phenanthroline)

A new six mixed Ligand complexes of some transition metal ions Mn (II) , Fe (II) , Co(II) , Ni(II), Cu(II)and non transition metal ion Cd(II)) with L-valine (Val H ) as a primary Ligand and 1,10-phenanthroline(phen) as a secondary Ligands have been prepared. All the prepared complexes have been characterized bymolar conductance, magnetic susceptibility infrared ,electronic spectral and AAA . The complexes with theformulas [M(Val)2(phen)] , M= Mn (II) , Fe (II) , Co(II) , Ni(II), Cu (II) ,and Cd(II) , L- Val H=(C5H11NO2) ,(C12H8N2) =(phen)Key words: Amino Acid,( L-valine), 1,10-Phenanthroline, mixed ligand complexes, Antibacterial activities,spectral studie

Synthesis of Poly (Acryl Lactate) with Ampicillin

Lactic acid was used as di functional spacer could esterified with poly acrylic acid gave its corresponding ester derivative with remain the carboxylic acid of lactate unit which reacted with amino group of Ampicillin forming amide attachment, the prepared prodrug polymer have many improvement, it could enhanced the prodrug with easier hydrolysis through ester- amide groups with extended the arm pendant substituted drug, the modification percentage test was carried out, also it was characterized by FTIR and 1H-NMR spectroscopies. Controlled drug release was studied in different pH values at 37℃. High thermal stability of the drug polymer was observed by TG and DTG indicated the protection of drug with longer date. Keywords: Lactic acid, poly acrylic acid, Ampicillin