64 research outputs found
Precision Astrometry of a Sample of Speckle Binaries and Multiples with the Adaptive Optics Facilities at the Hale and Keck II Telescopes
Using the adaptive optics facilities at the 200-in Hale and 10-m Keck II, we
observed in the near infrared a sample of 12 binary and multiple stars and one
open cluster. We used the near diffraction limited images of these systems to
measure the relative separations and position angles between their components.
In this paper, we investigate and correct for the influence of the differential
chromatic refraction and chip distortions on our relative astrometric
measurements. Over one night, we achieve an astrometric precision typically
well below 1 miliarcsecond and occasionally as small as 40 microarcseconds.
Such a precision is in principle sufficient to astrometrically detect planetary
mass objects around the components of nearby binary and multiple stars. Since
we have not had sufficiently large data sets for the observed sample of stars
to detect planets, we provide the limits to planetary mass objects based on the
obtained astrometric precision.Comment: 18 pages, 8 figures, 9 tables, to appear in MNRA
Modeling the scaling properties of human mobility
While the fat tailed jump size and the waiting time distributions
characterizing individual human trajectories strongly suggest the relevance of
the continuous time random walk (CTRW) models of human mobility, no one
seriously believes that human traces are truly random. Given the importance of
human mobility, from epidemic modeling to traffic prediction and urban
planning, we need quantitative models that can account for the statistical
characteristics of individual human trajectories. Here we use empirical data on
human mobility, captured by mobile phone traces, to show that the predictions
of the CTRW models are in systematic conflict with the empirical results. We
introduce two principles that govern human trajectories, allowing us to build a
statistically self-consistent microscopic model for individual human mobility.
The model not only accounts for the empirically observed scaling laws but also
allows us to analytically predict most of the pertinent scaling exponents
Planet formation in Binaries
Spurred by the discovery of numerous exoplanets in multiple systems, binaries
have become in recent years one of the main topics in planet formation
research. Numerous studies have investigated to what extent the presence of a
stellar companion can affect the planet formation process. Such studies have
implications that can reach beyond the sole context of binaries, as they allow
to test certain aspects of the planet formation scenario by submitting them to
extreme environments. We review here the current understanding on this complex
problem. We show in particular how each of the different stages of the
planet-formation process is affected differently by binary perturbations. We
focus especially on the intermediate stage of kilometre-sized planetesimal
accretion, which has proven to be the most sensitive to binarity and for which
the presence of some exoplanets observed in tight binaries is difficult to
explain by in-situ formation following the "standard" planet-formation
scenario. Some tentative solutions to this apparent paradox are presented. The
last part of our review presents a thorough description of the problem of
planet habitability, for which the binary environment creates a complex
situation because of the presence of two irradation sources of varying
distance.Comment: Review chapter to appear in "Planetary Exploration and Science:
Recent Advances and Applications", eds. S. Jin, N. Haghighipour, W.-H. Ip,
Springer (v2, numerous typos corrected
Populations of planets in multiple star systems
Astronomers have discovered that both planets and binaries are abundant
throughout the Galaxy. In combination, we know of over 100 planets in binary
and higher-order multi-star systems, in both circumbinary and circumstellar
configurations. In this chapter we review these findings and some of their
implications for the formation of both stars and planets. Most of the planets
found have been circumstellar, where there is seemingly a ruinous influence of
the second star if sufficiently close (<50 AU). Hosts of hot Jupiters have been
a particularly popular target for binary star studies, showing an enhanced rate
of stellar multiplicity for moderately wide binaries (>100 AU). This was
thought to be a sign of Kozai-Lidov migration, however recent studies have
shown this mechanism to be too inefficient to account for the majority of hot
Jupiters. A couple of dozen circumbinary planets have been proposed around both
main sequence and evolved binaries. Around main sequence binaries there are
preliminary indications that the frequency of gas giants is as high as those
around single stars. There is however a conspicuous absence of circumbinary
planets around the tightest main sequence binaries with periods of just a few
days, suggesting a unique, more disruptive formation history of such close
stellar pairs.Comment: Invited review chapter, accepted for publication in "Handbook of
Exoplanets", ed. H. Deeg & J. A. Belmont
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3
Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3 gene (ATXN3), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein aggregates. Although there is no cure for SCA3, gene-silencing approaches to reduce toxic polyQ ATXN3 showed promise in preclinical models. However, a major limitation in translating putative treatments for this rare disease to the clinic is the lack of pharmacodynamic markers for use in clinical trials. Here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human biological fluids and discriminates patients with SCA3 from healthy controls and individuals with other ataxias. We show that polyQ ATXN3 serves as a marker of target engagement in human fibroblasts, which may bode well for its use in clinical trials. Last, we identified a single-nucleotide polymorphism that strongly associates with the expanded allele, thus providing an exciting drug target to abrogate detrimental events initiated by mutant ATXN3. Gene-silencing strategies for several repeat diseases are well under way, and our results are expected to improve clinical trial preparedness for SCA3 therapies
Simultaneous Mutations in Multi-Viral Proteins Are Required for Soybean mosaic virus to Gain Virulence on Soybean Genotypes Carrying Different R Genes
BACKGROUND: Genetic resistance is the most effective and sustainable approach to the control of plant pathogens that are a major constraint to agriculture worldwide. In soybean, three dominant R genes, i.e., Rsv1, Rsv3 and Rsv4, have been identified and deployed against Soybean mosaic virus (SMV) with strain-specificities. Molecular identification of virulent determinants of SMV on these resistance genes will provide essential information for the proper utilization of these resistance genes to protect soybean against SMV, and advance knowledge of virus-host interactions in general. METHODOLOGY/PRINCIPAL FINDINGS: To study the gain and loss of SMV virulence on all the three resistance loci, SMV strains G7 and two G2 isolates L and LRB were used as parental viruses. SMV chimeras and mutants were created by partial genome swapping and point mutagenesis and then assessed for virulence on soybean cultivars PI96983 (Rsv1), L-29 (Rsv3), V94-5152 (Rsv4) and Williams 82 (rsv). It was found that P3 played an essential role in virulence determination on all three resistance loci and CI was required for virulence on Rsv1- and Rsv3-genotype soybeans. In addition, essential mutations in HC-Pro were also required for the gain of virulence on Rsv1-genotype soybean. To our best knowledge, this is the first report that CI and P3 are involved in virulence on Rsv1- and Rsv3-mediated resistance, respectively. CONCLUSIONS/SIGNIFICANCE: Multiple viral proteins, i.e., HC-Pro, P3 and CI, are involved in virulence on the three resistance loci and simultaneous mutations at essential positions of different viral proteins are required for an avirulent SMV strain to gain virulence on all three resistance loci. The likelihood of such mutations occurring naturally and concurrently on multiple viral proteins is low. Thus, incorporation of all three resistance genes in a soybean cultivar through gene pyramiding may provide durable resistance to SMV
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