52 research outputs found

    Bridging conventional and molecular genetics of sorghum insect resistance

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    Sustainable production of sorghum, Sorghum bicolor (L.) Moench, depends on effective control of insect pests as they continue to compete with humans for the sorghum crop. Insect pests are a major constraint in sorghum production, and nearly 150 insect species are serious pests of this crop worldwide and cause more than 9% loss annually. Annual losses due to insect pests in sorghum have been estimated to be 1,089millioninthesemiaridtropics(ICRISATAnnualreport1991.InternationalCropResearchInstituteforSemi−aridTropics.Patancheru,AndhraPradesh,India,1992),butdifferinginmagnitudeonaregionalbasis.KeyinsectpestsintheUSAincludethegreenbug,Schizaphisgraminum(Rondani);sorghummidge,Stenodiplosissorghicola(Coquillett);andvariouscaterpillarsintheSouthernareas.Forexample,damagebygreenbugtosorghumisestimatedtocostUSproducers1,089 million in the semiarid tropics (ICRISAT Annual report 1991. International Crop Research Institute for Semi-arid Tropics. Patancheru, Andhra Pradesh, India, 1992), but differing in magnitude on a regional basis. Key insect pests in the USA include the greenbug, Schizaphis graminum (Rondani); sorghum midge, Stenodiplosis sorghicola (Coquillett); and various caterpillars in the Southern areas. For example, damage by greenbug to sorghum is estimated to cost US producers 248 million annually. The major insect pests of sorghum on a global basis are the greenbug, sorghum midge, sorghum shoot fly (Atherigona soccata Rond.), stem borers (Chilo partellus Swin. and Busseola fusca Fuller), and armyworms (Mythimna separata Walk and Spodoptera frugiperda J.E. Smith). Recent advances in sorghum genetics, genomics, and breeding have led to development of some cutting-edge molecular technologies that are complementary to genetic improvement of this crop for insect pest management. Genome sequencing and genome mapping have accelerated the pace of gene discovery in sorghum..

    Tight junctions: from simple barriers to multifunctional molecular gates

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    Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains and are linked to the machinery that controls apicobasal polarization. Additionally, signalling networks that guide diverse cell behaviours and functions are connected to tight junctions, transmitting information to and from the cytoskeleton, nucleus and different cell adhesion complexes. Recent advances have broadened our understanding of the molecular architecture and cellular functions of tight junctions

    DAMTRNN: A Delta attention-based multi-task RNN for intention recognition

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    Recognizing human intentions from electroencephalographic (EEG) signals is attracting extraordinary attention from the artificial intelligence community because of its promise in providing non-muscular forms of communication and control to those with disabilities. So far, studies have explored correlations between specific segments of an EEG signal and an associated intention. However, there are still challenges to be overcome on the road ahead. Among these, vector representations suffer from the enormous amounts of noise that characterize EEG signals. Identifying the correlations between signals from adjacent sensors on a headset is still difficult. Further, research not yet reached the point where learning models can accept decomposed EEG signals to capture the unique biological significance of the six established frequency bands. In pursuit of a more effective intention recognition method, we developed DAMTRNN, a delta attention-based multi-task recurrent neural network, for human intention recognition. The framework accepts divided EEG signals as inputs, and each frequency range is modeled separately but concurrently with a series of LSTMs. A delta attention network fuses the spatial and temporal interactions across different tasks into high-impact features, which captures correlations over longer time spans and further improves recognition accuracy. Comparative evaluations between DAMTRNN and 14 state-of-the-art methods and baselines show DAMTRNN with a record-setting performance of 98.87% accuracy

    Utilization of Papanicolaou Smears by South Asian Women Living in the United States

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    OBJECTIVES: Papanicolaou (Pap) smears are an underutilized screening modality among racial and ethnic minorities. However, no data exist on Pap smear utilization among South Asians, a rapidly growing population in the United States, whose country of origin includes India, Pakistan, Bangladesh, and Sri Lanka. We determined rates and identified variables associated with Pap smear receipt by South Asians. DESIGN: A self-administered survey instrument was mailed to a random sample of South Asians nationwide over a 3-month time period. South Asian households were identified by surnames that were used to search white pages in telephone directories, Department of Motor Vehicle records, and voter registries. Questions regarding Pap smear receipt were taken from the 1999 National Health Interview Survey. Sociodemographic information and measures of acculturation were obtained. PARTICIPANTS: A nationwide nonprobability sample of South Asian women. INTERVENTION: Cross-sectional observational study. MEASUREMENTS AND MAIN RESULTS: The overall response rate was 42%. In this sample, South Asians belonged to a high socioeconomic strata (SES), with 45% having a household income of >$80,000 and 42% having a master's degree. Three quarters of the respondents (73%) reported having a Pap smear in the last 3 years. In multivariate logistic regression analysis, South Asian women had greater odds of having had a Pap smear if they were married (P < .001), more educated (P = .004), had a usual source of care (P = .002), and were more acculturated (P = .004). CONCLUSIONS: Despite the high SES of South Asian women, their rates of Pap smear receipt were lower than national recommendations. Marital status, socioeconomic status, and acculturation are all associated with Pap smear receipt. South Asian communities should be targeted for outreach to promote Pap smear utilization
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