11 research outputs found
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems
The need to connect: on the cell biology of synapses, behaviors, and networks in science
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1