ECHINOCANDINS VERSUS DATED ANTIFUNGALS IN COMBINATION AGAINST OPPORTUNISTIC MYCOTIC INFECTIONS

Scientific and clinical reports globally demonstrated that the opportunistic mycotic infections are at major risk to the human fitness. In past few decades, development of resistance in microbes to existing antifungals, has emphasized on the search of new antimycotic drugs. As a matter of fact "echinocandins" are new categories of broad-spectrum antifungal enlighten a hope in this direction. Echinocandins are bulky lipopeptides that inhibits the production of β-[1,3]-glucan "a major constituent of fungal cell wall" which ultimately leads to the death of fungal pathogens. In vitro as well as in vivo published reports have demonstrated that the echinocandins exhibit fungicidal activity against most Candida spp while fungistatic against Aspergillus spp and exclusively found to be more effective when tested in combination with polyenes/azoles. Present article is an expert views on the recent and historical literature available on the antifungal therapies with accessing their impact on the human health. Emphasis is given on the utility of the echinocandins as potential antifungal agent by discussing recent examples of clinical and laboratory studies including the use of improved proteomics approaches to know a bit more about the interaction of human host and fungal pathogens

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Not AvailableSuccess in the outcomes of applied assisted reproductive techniques mainly relies on the quality of the semen. Oxidative stress created by Reactive Oxygen Species (ROS) and Lipid Peroxidation (LPO) generated during different steps of semen preservation reduces semen quality. Melatonin and canthaxanthin are potent antioxidants involved in many biological processes. They have excellent capacity to scavenge free radicals, combat against oxidative stress and improve endogenous antioxidant defenses. Melatonin is well established antioxidant in semen preservation to protect against oxidative stress-induced damage; however, little literature is available on use of canthaxanthin as semen extender additive. Melatonin and its metabolites act as direct or indirect scavenger of free radicals arrest LPO and reduce generation of ROS, hence oxidative stress, thereby shielding seminal quality to prolong sperm morphological and functional attributes. Similar to melatonin, canthaxanthin by virtue of its antioxidant potential has shown promising results in preserving the seminal quality as well as their efficiency to reduce and/or prevent sperm damages during storage. This brief review encapsulated new uncovering related to the beneficial antioxidant effects of melatonin and canthaxanthin on semen preservation along with future perspective in respect of different combination and/or concentration along with fertility trails.Not Availabl

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