13 research outputs found
Improved adaptation to physical stress in mice overexpressing SUR2A is associated with changes in the pattern of Q-T interval
Comment on: “The General Adaptation Syndrome: A Foundation for the Concept of Periodization”
Authors’ Reply to Buckner et al.: ‘Comment on: “The General Adaptation Syndrome: A Foundation for the Concept of Periodization”
Investigation of pelvic pain: a “Gynaecologist-Gastroenterologist” collegial approach applied to chronic forms
Endoscopic removal of tracheobronchial foreign bodies: results on a series of 51 pediatric patients
Guidance for the Harmonisation and Improvement of Economic Evaluations of Personalised Medicine
The Role of Precision Medicine in the Diagnosis and Treatment of Patients with Rare Cancers.
Rare cancers pose unique challenges for patients and their physicians arising from a lack of information regarding the best therapeutic options. Very often, a lack of clinical trial data leads physicians to choose treatments based on small case series or case reports. Precision medicine based on genomic analysis of tumors may allow for selection of better treatments with greater efficacy and less toxicity. Physicians are increasingly using genetics to identify patients at high risk for certain cancers to allow for early detection or prophylactic interventions. Genomics can be used to inform prognosis and more accurately establish a diagnosis. Genomic analysis may also expose therapeutic targets for which drugs are currently available and approved for use in other cancers. Notable successes in the treatment of previously refractory cancers have resulted. New more advanced sequencing technologies, tools for interpretation, and an increasing array of targeted drugs offer additional hope, but challenges remain