631 research outputs found
Sqrt{shat}_{min} resurrected
We discuss the use of the variable sqrt{shat}_{min}, which has been proposed
in order to measure the hard scale of a multi parton final state event using
inclusive quantities only, on a SUSY data sample for a 14 TeV LHC. In its
original version, where this variable was proposed on calorimeter level, the
direct correlation to the hard scattering scale does not survive when effects
from soft physics are taken into account. We here show that when using
reconstructed objects instead of calorimeter energy and momenta as input, we
manage to actually recover this correlation for the parameter point considered
here. We furthermore discuss the effect of including W + jets and t tbar+jets
background in our analysis and the use of sqrt{shat}_{min} for the suppression
of SM induced background in new physics searches.Comment: 23 pages, 9 figures; v2: 1 figure, several subsections and references
as well as new author affiliation added. Corresponds to published versio
Simulation of the 21 August 2017 Solar Eclipse Using the Whole Atmosphere Community Climate Model-eXtended
We performed simulations of the atmosphereâionosphere response to the solar eclipse of 21 August 2017 using the Whole Atmosphere Community Climate ModelâeXtended (WACCMâX v. 2.0) with a fully interactive ionosphere and thermosphere. Eclipse simulations show temperature changes in the path of totality up to â3 K near the surface, â1 K at the stratopause, ±4 K in the mesosphere, and â40 K in the thermosphere. In the F region ionosphere, electron density is depleted by about 55%. Both the temperature and electron density exhibit global effects in the hours following the eclipse. There are also significant effects on stratosphereâmesosphere chemistry, including an increase in ozone by nearly a factor of 2 at 65 km. Dynamical impacts of the eclipse in the lower atmosphere appear to propagate to the upper atmosphere. This study provides insight into coupled eclipse effects through the entire atmosphere from the surface through the ionosphere
Repeatability of beach morphology change under identical wave forcing
Laboratory investigations of beach morphology change under wave action are undertaken to gain insight into coastal processes, design coastal structures and validate the predictions of numerical models. For the results of such experiments to be reliable, it is necessary that they are repeatable. The equilibrium beach concept, that beach morphology will evolve to a quasi-static equilibrium shape for a given forcing suggests that experiments should be repeatable to some degree. However, sediment transport in turbulent breaking and broken waves is complex and highly variable and the level of repeatability at different temporal and spatial scales is challenging to measure, as such, previous work has restricted comparisons to small numbers of waves. Here we use the results of two identical, 20-h large-scale wave flume experiments to investigate the repeatability of sediment transport and beach morphology change under waves at timescales down to individual swash events. It is shown that while flow characteristics from identical swash events are very repeatable, the sediment transported can be very different in both magnitude and direction due to differences in turbulence, sediment advection and morphological feedback. Over longer periods containing multiple matching swash events however, the beach responds in a very similar manner, with the level of morphological repeatability increasing with time. The results also demonstrate that gross swash zone sediment transport remains high even as a beach profile approaches quasi-equilibrium, but the proportion of individual swash events that cause large sediment fluxes (>±7.5 kg/event/m) reduces with time. The results of this laboratory study indicate that beach morphology change has a level of determinism over timescales of several minutes and longer, giving confidence in the results from physical modelling studies. However, the large differences in sediment transport from apparently identical swash events questions the value in pursuing numerical predictions of sediment transport at the wave-by-wave timescale unless the reversals in sediment transport between apparently near identical swash events can also be predicted
The effect of parental wealth on childrenâs outcomes in early adulthood
Using data from the British Household Panel Survey we show that parental wealth has a positive association with a range of outcomes in early adulthood. The outcome that exhibits the strongest association with parental wealth is higher educational attainment. This association is mainly concentrated at the lower half of the distribution and remains strong after controlling for a wide range confounding family characteristics. Parental wealth also has a positive relationship with childrenâs employment probability and earnings, although the gradient for both outcomes is rather weak and largely mediated by childrenâs education. A potential driver of the small size of the latter effects is the young age of the sample
Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma
Rhabdomyosarcoma accounts for roughly 1% of adult sarcomas, with pleomorphic rhabdomyosarcoma (PRMS) as the most common subtype. Survival outcomes remain poor for patients with PRMS, and little is known about the molecular drivers of this disease. To better characterize PRMS, we performed a broad array of genomic and immunostaining analyses on 25 patient samples. In terms of gene expression and methylation, PRMS clustered more closely with other complex karyotype sarcomas than with pediatric alveolar and embryonal rhabdomyosarcoma. Immune infiltrate levels in PRMS were among the highest observed in multiple sarcoma types and contrasted with low levels in other rhabdomyosarcoma subtypes. Lower immune infiltrate was associated with complete loss of both TP53 and RB1. This comprehensive characterization of the genetic, epigenetic, and immune landscape of PRMS provides a roadmap for improved prognostications and therapeutic exploration
Cytomolecular identification of individual wheat-wheat chromosome arm associations in wheat-rye hybrids
Chromosome pairing in the meiotic metaphase I of wheatrye
hybrids has been characterized by sequential genomic
and fluorescent in situ hybridization allowing not only the
discrimination of wheat and rye chromosomes, but also the
identification of the individual wheat and rye chromosome
arms involved in the chromosome associations. The majority
of associations (93.8%) were observed between the wheat
chromosomes. The largest number of wheat-wheat chromosome
associations (53%) was detected between the A and D
genomes, while the frequency of B-D and A-B associations
was significantly lower (32 and 8%, respectively). Among the
A-D chromosome associations, pairing between the 3AL and
3DL arms was observed with the highest frequency, while
the most frequent of all the chromosome associations (0.113/
cell) was found to be the 3DS-3BS. Differences in the pairing
frequency of the individual chromosome arms of wheat-rye
hybrids have been discussed in relation to the homoeologous
relationships between the constituent genomes of
hexaploid wheat
The rapid assembly of an elliptical galaxy of 400 billion solar masses at a redshift of 2.3
Stellar archeology shows that massive elliptical galaxies today formed
rapidly about ten billion years ago with star formation rates above several
hundreds solar masses per year (M_sun/yr). Their progenitors are likely the
sub-millimeter-bright galaxies (SMGs) at redshifts (z) greater than 2. While
SMGs' mean molecular gas mass of 5x10^10 M_sun can explain the formation of
typical elliptical galaxies, it is inadequate to form ellipticals that already
have stellar masses above 2x10^11 M_sun at z ~ 2. Here we report
multi-wavelength high-resolution observations of a rare merger of two massive
SMGs at z = 2.3. The system is currently forming stars at a tremendous rate of
2,000 M_sun/yr. With a star formation efficiency an order-of-magnitude greater
than that of normal galaxies, it will quench the star formation by exhausting
the gas reservoir in only ~200 million years. At a projected separation of 19
kiloparsecs, the two massive starbursts are about to merge and form a passive
elliptical galaxy with a stellar mass of ~4x10^11 M_sun. Our observations show
that gas-rich major galaxy mergers, concurrent with intense star formation, can
form the most massive elliptical galaxies by z ~ 1.5.Comment: Appearing in Nature online on May 22 and in print on May 30.
Submitted here is the accepted version (including the Supplementary
Information), see nature.com for the final versio
Selective IgA Deficiency
Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA in the presence of normal levels of other immunoglobulin isotypes. Most individuals with IgA deficiency are asymptomatic and identified coincidentally. However, some patients may present with recurrent infections of the respiratory and gastrointestinal tracts, allergic disorders, and autoimmune manifestations.
Although IgA is the most abundant antibody isotype produced in the body, its functions are not clearly understood. Subclass IgA1 in monomeric form is mainly found in the blood circulation, whereas subclass IgA2 in dimeric form is the dominant immunoglobulin in mucosal secretions. Secretory IgA appears to have prime importance in immune exclusion of pathogenic microorganisms and maintenance of intestinal homeostasis. Despite this critical role, there may be some compensatory mechanisms that would prevent disease manifestations in some IgA-deficient individuals.
In IgA deficiency, a maturation defect in B cells to produce IgA is commonly observed. Alterations in transmembrane activator and calcium modulator and cyclophilin ligand interactor gene appear to act as disease-modifying mutations in both IgA deficiency and common variable immunodeficiency, two diseases which probably lie in the same spectrum. Certain major histocompatibility complex haplotypes have been associated with susceptibility to IgA deficiency.
The genetic basis of IgA deficiency remains to be clarified. Better understanding of the production and function of IgA is essential in elucidating the disease mechanism in IgA deficiency
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