Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations

The non-specific, hyperpolarization activated, Ih current is particularly involved in epilepsy and it exhibits an excitatory or inhibitory action on synaptic integration in an apparently inconsistent way. It has been suggested that most of the inconsistencies could be reconciled invoking an indirect interaction with the M-type K+ current, another current involved in epilepsy. However, here we show that the original experiments, and the simplified model used to explain and support them, cannot explain in a conclusive way the puzzling Ih actions observed in different experimental preparations. Using a realistic model, we show instead how and why a shunting current, such as that carried by TASK-like channels, and dependent on Ih channel is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions. The model results suggest several experimentally testable predictions to characterize in more details this elusive and peculiar interaction, which may be of fundamental importance in the development of new treatments for all those pathological and cognitive dysfunctions caused, mediated, or affected by Ih

Examining the Effect of Community Participation on Beneficiary Satisfaction with the work of Water Management Committee in Urban Community-based Operated Water Schemes

Community participation (CP) has become popular in development discourse and practice, particularly in relation to water resource management. Greater involvement of beneficiaries in decision-making and implementation of water management practices is expected to increase efficiency and equity. However, the lingering question remains—Does CP necessarily result in outcomes of greater beneficiary satisfaction? Relatively little is known about the linkage. This article seeks to examine the relationship between community participation and beneficiary satisfaction with the work of the water management committee. Four urban-based community operated water schemes in the city of Kisumu, Kenya, are used as empirical referent. We applied quantitative research methodology by conducting a detailed survey and logistic regression analytic technique to analyze the data. We used seven parameters/indicators to operationalize participation and one to ascertain satisfaction with the work of the water management committee. Our results indicate that five participatory variables correlate with beneficiary satisfaction with the work of the water management committees including provision of labor (p \u3c .05), willingness to intervene against vandalism (p \u3c .05), meeting attendance (p \u3c .05), financial contribution (p \u3c .05) and payments of water bills on time (p \u3c .05). These findings suggest that managers of community water supplies projects together with development partners need to encourage the identified participatory variables as a means of augmenting beneficiary satisfaction and most importantly improving effectiveness/sustainability