5 research outputs found
Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib
- Author
- A Foudi
- A Gothot
- A Strife
- A Wilson
- AHG Hamilton
- AR Oller
- Bayard Clarkson
- BJ Druker
- C Cobaleda
- C Roche-Lestienne
- CH Jamieson
- Christophe Fraser
- CL Sawyers
- D Dingli
- E Passegue
- F Arai
- F Michor
- F Michor
- F Michor
- Franziska Michor
- GB Bradford
- H Glimm
- HG Jorgensen
- I Roeder
- J Cashman
- J Cortes
- Jasmine Foo
- JC Wang
- JD Rowley
- JF Apperley
- KJ Hope
- KW Orford
- L Ponchio
- M Holtz
- Mark W. Drummond
- ME Gorre
- MJ Mauro
- MW Drummond
- N Uchida
- NL Komarova
- NL Komarova
- NP Shah
- P Rousselot
- PS Kim
- S Branford
- S Branford
- S Merante
- SM Graham
- T Higashi
- T Holyoake
- T Lapidot
- T Reya
- Tessa Holyoake
- TL Holyoake
- W Ghanima
- WR Bruce
- Y Wang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2009
- Field of study
Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell compartment. Quiescence of leukemic stem cells has been suggested as a mechanism conferring insensitivity to imatinib, and exposure to the Granulocyte-Colony Stimulating Factor (G-CSF), together with imatinib, has led to a significant reduction in leukemic stem cells in vitro. In this paper, we design a novel mathematical model of stem cell quiescence to investigate the treatment response to imatinib and G-CSF. We find that the addition of G-CSF to an imatinib treatment protocol leads to observable effects only if the majority of leukemic stem cells are quiescent; otherwise it does not modulate the leukemic cell burden. The latter scenario is in agreement with clinical findings in a pilot study administering imatinib continuously or intermittently, with or without G-CSF (GIMI trial). Furthermore, our model predicts that the addition of G-CSF leads to a higher risk of resistance since it increases the production of cycling leukemic stem cells. Although the pilot study did not include enough patients to draw any conclusion with statistical significance, there were more cases of progression in the experimental arms as compared to continuous imatinib. Our results suggest that the additional use of G-CSF may be detrimental to patients in the clinic
Genetic, morphometric and immunohistochemical features of latent coeliac disease
- Publication venue
- Publication date
- 01/01/1999
- Field of study
Metallogenic Belts and Angle of Dip of Benioff Zones
- Author
- AHG Mitchell
- BP Luyendyk
- C Halls
- CR Stern
- DE James
- DE Karig
- DE Karig
- DR Bracey
- EJ Cobbing
- EJ Cobbing
- FJ Dewey
- FJ Sawkins
- G Tischendorf
- GC Brown
- H Kuno
- J Pereira
- JA Katili
- JC Moore
- JF Dewey
- KS Rodolfo
- MG Rub
- MM Posavec
- MS Garson
- NJ Snelling
- P Jakes
- P Jakes
- P Jakes
- PW Guild
- RA Van Bemmelen
- RH Sillitoe
- RH Sillitoe
- T Matsuda
- T Matsumoto
- TJ Fitch
- W Hamilton
- Y Sekine
- Z Ben-Avraham
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Oceans and young island arc systems
- Author
- A Gudmundsson
- A Percerillo
- A Saunders
- AD Saunders
- AHG Mitchell
- AJ Warden
- AK Kennedy
- AN Moiseyev
- BC Heezen
- BG Weissberg
- BIA McInnes
- BIA McInnes
- BW Haynes
- C Coulon
- CJ Morgan
- CR German
- CS Hutchison
- CW Field
- DAH Teagle
- DF Sangster
- DL Leach
- DS Cronan
- DZ Piper
- EG Gurvich
- ES Kappel
- FJ Sawkins
- G Einsele
- G Hubred
- GA Macdonald
- GD Carman
- GN Baturin
- GP Glasby
- H Colley
- H Morozumi
- H Ohmoto
- IG Gass
- J Dymond
- J Francheteau
- J Greinert
- JB Comer
- JB Gill
- JC Carlile
- JC Scholten
- JDL White
- JH Brunn
- JL Mero
- JL Ritchey
- JM Franklin
- JP Richards
- JR Hein
- JR Hein
- KM Marsaglia
- M Koide
- MA Meylan
- MD Hannington
- MD Hannington
- MD Hannington
- MJ Mottl
- MR Perfit
- N Shikazono
- NF Exon
- P Fryer
- P Fryer
- P Fryer
- P Halbach
- P Halbach
- PA Rona
- PA Rona
- PC Hess
- PJ Coney
- PM Herzig
- PM Herzig
- R Huene von
- R HĂ©kinian
- RA Binns
- RA Koski
- RA Koski
- RA Zierenberg
- RAF Cas
- RG Coleman
- RG Coleman
- RH Sillitoe
- RH Sillitoe
- RJ Goldfarb
- RK Vessell
- RL Stanton
- RM Haymon
- RW Bemmelen Van
- RW Kay
- S Bloch
- S MaalĂže
- S Petersen
- S Petersen
- SD Scott
- SM Peacock
- T Urabe
- U Stackelberg von
- VE McKelvey
- WB Hamilton
- WB Hamilton
- WD Goodfellow
- WE Dean
- Y Fouquet
- Y Fouquet
- Y Tatsumi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
JCS/JHRS 2019 guideline on nonâpharmacotherapy of cardiac arrhythmias
- Author
- Abadir S
- Abdelrahman M
- Abraham WT
- Abraham WT
- Abreu Filho CA
- Acosta J
- Ad N
- Ad N
- Ad N
- Ad N
- Ad N
- Afari ME
- Aiba T
- Ailawadi G
- Ainsworth CD
- Aiyagari R
- Aizawa Y
- Aizawa Y
- Al Halabi S
- Alexander ME
- Allessie MA
- Almendral JM
- Alonso C
- AlâKhatib SM
- AlâKhatib SM
- American Board of Internal Medicine
- American Society of Anesthesiologists Task Force on Sedation and Analgesia by NonâAnesthesiologists
- Ammirati F
- Amsterdam EA
- An HS
- Anand RG
- Anderson RH
- Anderson RH
- Andrade JG
- Andreu D
- Andreu D
- Anter E
- Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators
- Antonelli D
- Antzelevitch C
- Aonuma K
- Araki Y
- Aranda JM
- Arenal A
- Arenal A
- Arenal A
- Arruda MS
- Arya A
- Aryana A
- Atarashi H
- Attaran S
- Auricchio A
- Auricchio A
- Avari JN
- Avitall B
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- Aydin A
- Azegami K
- BabuâNarayan SV
- Baddour LM
- Badhwar V
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- BaezâEscudero JL
- BaezâEscudero JL
- Bagchi D
- Baher A
- Bakker PF
- Baldinger SH
- Baman TS
- Bando K
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- Bansch D
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- Barakat AF
- Bardy GH
- Bardy GH
- Barnett SD
- Bary C
- BarâCohen Y
- Basso C
- Bastani H
- Beder SD
- Behr ER
- Benson DW
- Berruezo A
- Berruezo A
- Bertels RA
- Beshai JF
- Betensky BP
- Bhargava M
- Bhavani SS
- Bhonsale A
- Bigger JT
- Bisleri G
- Blackshear JL
- Blanck Z
- Blaufox AD
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- Bode K
- Boersma L
- Boersma LV
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- Bogun F
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- Bollmann A
- Bongiorni MG
- Bordachar P
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- Borggrefe M
- Boriani G
- Bos JM
- Bourier F
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- Bricker JT
- Brignole M
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- Bromberg BI
- Brooks AG
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- Brugada J
- Brugada J
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- Brunckhorst CB
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- Buxton AE
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- Callans DJ
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- Cappato R
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- Carbucicchio C
- Carreras EM
- CasadoâArroyo R
- Cazeau S
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- Cazeau SJ
- Cecchi F
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- Cesario DA
- Chae S
- Chang HY
- Chang SL
- Chatterjee NA
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- Cheezum MK
- Chen CA
- Chen J
- Chen L
- Chen SA
- Chen SA
- Chen YH
- Chen YJ
- Cheng DC
- Cheng YJ
- Cherniavsky A
- Chetaille P
- Chevalier P
- Chierchia GB
- Chikata A
- Chillou C
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- Chimenti C
- Chinushi M
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- Choi EK
- Choi EK
- Choi GR
- Christoph M
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- Ciaccio EJ
- Ciconte G
- Claesson JE
- Cleland JG
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- Codreanu A
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- Collins KK
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- Collura CA
- Connolly SJ
- Connolly SJ
- Connolly SJ
- Connolly SJ
- Connolly SJ
- Conte G
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- Conti JB
- Corrado D
- Corrado D
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- Cox JL
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- Crossley GH
- Crossley GH
- Crosson JE
- Curtis AB
- Cutler MJ
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- De Pooter J
- Deanfield JE
- Deisenhofer I
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- Dekker AL
- Delacretaz E
- Delise P
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- Deshmukh A
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- Dhingra RC
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- Domanski MJ
- Doppalapudi H
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- Dreifus LS
- Driessen AHG
- Dubin AM
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- Duff HJ
- Dukkipati SR
- Duncker D
- Duray GZ
- dâAvila A
- Ebe K
- Eckart RE
- Ector H
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- Edgerton JR
- Edgerton JR
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- Eisenberg SJ
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- Emmel M
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- Endo M
- Englund A
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- Escudero C
- Estner HL
- European Society of Cardiology
- Ezekowitz JA
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- Fishberger SB
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- Garikipati NV
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- Geldorp IE
- Gemein C
- Gersh BJ
- Gerstenfeld EP
- Gerstenfeld EP
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- Giacomino BD
- Gillinov AM
- Gillinov AM
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- Goldenberg I
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- Hachiya H
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- Haissaguerre M
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- Haissaguerre M
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- Haruki S
- Hasdemir C
- Hasdemır C
- Hayashi K
- Hayashi M
- Hayashi M
- Hayes DL
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- He X
- Healey JS
- Healthcare Engineering Association of Japan
- Heidbuchel H
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- Hofferberth SC
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- Igarashi M
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- JanouĆĄek J
- JanouĆĄek J
- January CT
- Japan Arrhythmia Device Industry Association
- Japan Resuscitation Council
- Japanese Circulation Society and Japanese Society of Pediatric Cardiology and Cardiac Surgery Joint Working Group
- Japanese Circulation Society Joint Working Group
- Japanese Circulation Society Joint Working Group
- Japanese Circulation Society Joint Working Group
- Japanese Circulation Society Joint Working Group
- Japanese Circulation Society Joint Working Group
- Japanese Circulation Society Joint Working Group
- Japanese Heart Rhythm Society
- Japanese Heart Rhythm Society Catheter Ablation Committee
- Japanese Society of Anesthesiologists
- Jarman JW
- Jarman JW
- Jauvert G
- JCS Joint Working Group
- Je HG
- Jeanrenaud X
- Jeevanantham V
- Jentzer JH
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- Josephson ME
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- Kalman JM
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- Kaneshiro T
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- Kappenberger LJ
- Karamlou T
- Karch MR
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- Kasanuki H
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- Keida T
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- Kindermann M
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- Kirchhof P
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- Klein GJ
- Klein HU
- Klemm HU
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- Ko JK
- Kobe J
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- Kocovic DZ
- Kohno R
- Komatsu Y
- Komatsu Y
- Komatsu Y
- Komatsu Y
- Komatsu Y
- Konta L
- Kopecky SL
- Koplan BA
- Koplan BA
- Koplan BA
- Korniewicz DM
- Koruth JS
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- Kosakai Y
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- Kozak LJ
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- Kreidieh B
- Kreutzer J
- Kronborg MB
- Krongrad E
- Krul SP
- Kubus P
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- Kuck KH
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- Kugler JD
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- Kumagai K
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- Kumar S
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- Kurosaki K
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- Mind Treatment Guideline Selection Committee
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- Olde Nordkamp LR
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- Prabhu S
- Priori SG
- Priori SG
- Priori SG
- Priori SG
- Priori SG
- Probst V
- Proclemer A
- Providencia R
- Pruitt JC
- Pruitt JC
- Raju H
- Ramza BM
- Rasmussen K
- Raviele A
- Reddy VY
- Reddy VY
- Reddy VY
- Reddy VY
- Reddy VY
- Reddy VY
- Reddy VY
- Reithmann C
- Reithmann C
- Ren JF
- Ressia L
- Reynolds D
- Reynolds MR
- Rhodes LA
- Rickard J
- Rijnbeek PR
- RiveroâAyerza M
- Roberts JD
- Roberts PR
- Rocken C
- RodriguezâManero M
- Roguin A
- Roguin A
- Rohacek M
- Rolf S
- Rolf S
- Rosenbaum F
- Rosenthal ME
- RosesâNoguer F
- Rostock T
- Rostock T
- Roston TM
- Roux JF
- Roy D
- Rubenstein JJ
- Ruschitzka F
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- Russo RJ
- Ruwald AC
- Ruwald MH
- Sacher F
- Sacher F
- Sachweh JS
- Sadoul N
- Sadron BlayeâFelice M
- Saghy L
- Sakamoto S
- Sakamoto S
- Sakamoto S
- Sakata K
- Salerno JC
- Salukhe TV
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- Sanders P
- Sanna T
- Santangeli P
- Santangeli P
- Santangeli P
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- Santoro F
- Saoudi N
- Sapp JL
- Sapp JL
- Sarrazin JF
- Sartipy U
- Sasaki S
- Sasaki S
- Sasaki T
- Sasaki T
- Satake H
- Satoh M
- Satomi K
- Sawhney N
- Saxon LA
- Scheinman MM
- Scheinman MM
- Scheinman MM
- Scheinman MM
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- Scherr D
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- Schmidinger H
- Schmidt B
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- Schneider HE
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- Schotten U
- Schreiber D
- Schron EB
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- Schwartz PJ
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- Schwartz PJ
- Scientific Statement from Japanese Heart Rhythm Society
- Sears SF
- Seiler J
- Sekiguchi Y
- Sharkey SW
- Sharma PS
- Sharma PS
- Shaw DB
- Shen WK
- Shiba N
- Shiga T
- Shiina Y
- Shimizu A
- Shimizu W
- Shimizu W
- Shirai Y
- Shivapour JK
- Sholler GF
- Siebermair J
- Sieira J
- Sigmund E
- Silka MJ
- Silka MJ
- Sinha AM
- Siontis KC
- Sipahi I
- Slotwiner D
- Slotwiner DJ
- Social Insurance Union of Societies Related to Internal Medicine
- Soejima K
- Soejima K
- Soejima K
- Soejima K
- Soejima K
- Soejima K
- Sohara H
- Sohara H
- Sohns C
- Solomon SD
- Sommer P
- Sommer P
- Sosa E
- Spector P
- Spector ZZ
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- Spirito P
- Sroubek J
- Stamm C
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- Su W
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- Sueda T
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- Suenari K
- Sumitomo N
- Sumiyoshi M
- Sumiyoshi M
- Sunsaneewitayakul B
- Sutton R
- Suyama K
- Suzuki T
- Suzuki T
- Suzuki T
- Suzuki Y
- Sweeney MO
- Syska P
- Sze E
- Szumowski L
- Tabib A
- Tada H
- Tada H
- Tada H
- Tada H
- Tai CT
- Takach TJ
- Takagi M
- Takagi M
- Takagi Y
- Takahashi A
- Takahashi A
- Takahashi M
- Takai H
- Takasaki T
- Take Y
- Takemoto M
- Takeshita N
- Takigawa M
- Takigawa M
- Talib AK
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- Talib AK
- Tamashita T
- Tamborero D
- Tandri H
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- Tang M
- Tanner H
- Tanno K
- Tchou P
- Tebbenjohanns J
- Teeter WA
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- Texter KM
- Thakur RK
- Thambo JB
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- The Japanese Circulation Society
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- Thibault B
- Thiene G
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- Thomas V
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- Timmermans C
- Tjong FV
- Tohei Y
- Tokano T
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- Tokuda M
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- Tolosana JM
- Tomaske M
- Tomaske M
- Tops LF
- Tracy CM
- Triedman JK
- Triedman JK
- Triedman JK
- Triedman JK
- Triedman JK
- Triedman JK
- Tsai YC
- Tse HF
- Tseng TW
- Tsuchihashi K
- Tsuchiya T
- Tsuji A
- Tsujii N
- Tsutsui H
- Tung R
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- Ueda A
- Ueda H
- Uemura H
- Uemura H
- Ueyama T
- Ullah W
- Ulphani JS
- Upadhyay S
- Vaitkevicius R
- Valderrabano M
- Valderrabano M
- Valente AM
- Van Hare GF
- Van Hare GF
- Van Hare GF
- Van Hare GF
- Van Herendael H
- Varma N
- Varma N
- Vaseghi M
- Venteclef N
- Vergara P
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- Vijayaraman P
- Vijayaraman P
- Vilades Medel D
- Villafane J
- Villain E
- Villain E
- Villain E
- Viswanathan K
- Vojtovic P
- Volkmer M
- Vollmann D
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- Von Bergen NH
- Vos CB
- Vriesendorp PA
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- Walsh EP
- Wang J
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- Watanabe E
- Watanabe E
- Watanabe H
- Wazni O
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- Weber H
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- Weindling SN
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- World Health Organization
- Wright M
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- Yagi H
- Yagishita A
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- Yamabe H
- Yamada T
- Yamada T
- Yamada T
- Yamada T
- Yamada T
- Yamagata K
- Yamaguchi T
- Yamaguchi Y
- Yamane T
- Yamasaki H
- Yamashiro K
- Yamauchi Y
- Yamauchi Y
- Yanaga T
- Yancy CW
- Yang B
- Yao X
- Yokokawa M
- Yokokawa M
- Yokokawa M
- Yokokawa M
- Yokoyama K
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- Yoshida N
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- Yoshitani K
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- Publication venue
- 'Wiley'
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- Field of study