Влияние индол-3-масляной кислоты и хлормеквата хлорида на рост растений томата

Relevance. This study aimed to improve fruit set and plant performance to increase tomato productivity by studying the effect of plant growth regulators on tomato plants.Methods. A specific experiment has been carried out to study the effect of plant growth regulators Milagro (1% indol-3-butric acid) and Atlet active substances indol-3-butric acid and chloromequate chloride with applied doses (0.6 M/L, 1.0 M/L and 1.5 M/L) and (1.0, 1.5 and 2.0 M/L) on growth and physiological characteristics of plants (Big Beef F1). The experimental design was a Complete Randomized Blocks Design. Both Hemo bles was applied three times (spraying on plants at 30 DAP, spraying on plants at 60 DAP and spraying on plants 90 DAP).Results. The obtained results showed that, Applying Milagro (1% indol-3-butric acid) had the highest significant Plant height (80.13, 128.77 and 239 cm), number of leaves/plant (18.0, 34.67 and 44.3) and stem diameter (1.07, 1.5 and 2.03 cm), fruit weight (122.0 and 136 g), Flower Clusters number in the plant (4.64, 13.33 and 16.33) and Fruits Number (61.67, 62.0 and 67) Over the three years of study. The results were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s HSD test with α = 0.05 with the help of MINITAB (v. 19.0) program.Актуальность. Исследование было направлено на улучшение плодоношения и продуктивности растений для увеличения урожайности томатов путем изучения влияния регуляторов роста растений.Материал и методы. Проведен эксперимент по изучению влияния регуляторов роста растений Милагро (1% индол-3-масляная кислота) и активных веществ Атлет – индол-3-масляной кислоты и хлормеквата хлорида, применяемых в дозах (0,6 м/л, 1,0 м/л) и 1,5 м/л) и (1,0, 1,5 и 2,0 м/л) по росту и физиологическим характеристикам растений (Big Beef F1). Оба регулятора роста наносили три раза (опрыскивание растений при 30 DAP, опрыскивание растений при 60 DAP и опрыскивание растений при 90 DAP).Результаты. Применение Милагро (1% индол-3-масляной кислоты) оказало наибольшее влияние на высоту растений (80,13, 128,77 и 239 см), количество листьев / растений (18,0, 34,67 и 44,3) и диаметр стебля (1,07, 1,5 и 2,03 см), массу плодов (122,0 и 136 г), количество цветочных кистей на растении (4,64, 13,33 и 16,33) и количество плодов (61,67, 62,0 и 67) в течение трех лет исследования. Результаты были проанализированы с использованием одностороннего дисперсионного анализа (ANOVA) с последующим HSD-тестом Тьюки с α = 0,05 с помощью программы MINITAB (v. 19,0)

What Matters Most: Determinants Associated with the Selection of Medical Residencies in Qatar.

PURPOSE: There have been several studies into medical student career decision making in occidental countries (eg US, UK), but medical career selection in a Middle Eastern context has not been as well studied. This study aims to explore determinants underpinning medical students' residency choice in Qatar. PATIENTS AND METHODS: During the Fall semester of the 2022-2023 academic year, all (n=358) medical students from the College of Medicine at Qatar University were invited to participate in an online explorative questionnaire about students' career choices and the factors determining their selection. RESULTS: Of the 358 students, 184 responded (51%). Respondents had a mean age of 20 years; the majority were female (73.9%), Qatari (54.3%), unmarried (97.3%), and enrolled in a pre-clerkship year (55.0%). The most important career determinant was specialty-specific factors. The relative importance of other determinants differed by gender and stage of training. Among our respondents, male students were more likely to rate role models and influencers as being important to their choice, while female students and Qatari students overall were more likely to cite societal obligation. Medical students in Qatar seemed to have career preferences in mind upon entry into medical education. Later-year students were more likely to identify the importance of work-life balance and place of practice, but were less likely to rank prestige and income as an important determinant. CONCLUSION: The results of this baseline study suggest that socioeconomic and cultural context influence medical student career decisions

Влияние регуляторов роста на качество плодов томата

Relevance and methods. This study aimed to improve fruit set and plant performance to increase tomato productivity by studying the effect of plant growth regulators on tomato plants. A specific experiment has been carried out to study the effect of plant growth regulators Hemo bles active substances (850 g/kg) Humic Acid with applied doses (250, 500 and 700 ppm) and Magictone active substances (5-12.5 g/kg) naphthalene acetic acid and naphthalene acetamide with applied doses (250, 500 and 700 ppm) on growth and physiological characteristics of tomato plants (Big Beef F1). The experimental design was a Complete Randomized Blocks Design. Both Hemo bles and Magictone were applied three times (spraying on plants at 30 DAP, spraying on plants at 60 DAP and spraying on plants 90 DAP).Results. The obtained results showed that, Applying Humic Acid “Ener-850” had the highest significant fruit weight (137 g) during the two seasons. Also using “Magictone” had the highest significant Flowers number (48.1), Fruits Number (35.1), Flower Clusters number in the plant (13.6) and Fruits Number (54.6. while (Humic Acid) improved tomato fruit’s quality during improve Dry weight (75.1 g) of Arial parts, Ascorbic Acid, level of Vitamin C and Carotenoids contents (4.82 mg 100 g-1). The results were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s HSD test with α = 0.05 with the help of MINITAB (v. 19.0) program.Актуальность и методика. Наши исследования были направлены на изучение влияния регуляторов роста Hemo bles и Magictone на продуктивность томата Биг Биф F1 (Big Beef F1). Гибрид среднеспелый, индетерминантного типа. Обработку проводили 3 раза с интервалом в 30 дней, концентрация растворов – 250 мг/л, 500 мг/л, 700 мг/л.Результаты. В результате исследований установлено, что применение Hemo bles (гуминовая кислота, 850 г/кг) и Magictone (нафталин уксусная кислота и нафталин ацетамид, 5-12,5 г/кг) увеличивает показатели продуктивности растений томата. При обработке Magictone наблюдали наибольшее количество плодов на растении – 63,7 шт., количество кистей 14,2 шт. и массу одного плода – 144,0 г, в то время как Hemo bles оказывал наибольшее влияние на показатели: содержание сухого вещества до 7,65%, содержание аскорбиновой кислоты – до 27,0 мг/100 г и каротиноидов – 4,92 мг/100 г в среднем за два года. Результаты были проанализированы с использованием однофакторного дисперсионного анализа (ANOVA) с последующим HSD-тестом Тьюки с α = 0,05 с помощью программы MINITAB (v. 19.0)

Efficacy and Safety of Cabergoline as First Line Treatment for Invasive Giant Prolactinoma

Although cabergoline is effective in the treatment of micro- and macro-prolactinoma, little is known about its efficacy in the treatment of invasive giant prolactinoma. We investigated the efficacy and safety of cabergoline in 10 male patients with invasive giant prolactinoma. Before treatment, mean serum prolactin level was 11,426 ng/mL (range, 1,450-33,200 ng/mL) and mean maximum tumor diameter was 51 mm (range, 40-77 mm). Three months after initiation of cabergoline treatment, serum prolactin concentrations decreased more than 97% in 9 patients; at last follow-up (mean treatment duration, 19 months), the mean decrease in serum prolactin concentrations was 98%, with 5 patients having normal serum prolactin levels. At first MRI follow-up (3-12 months after initiation of cabergoline), the mean reduction in tumor size was 85±4% (range, 57-98%). Cabergoline treatment for more than 12 months caused a greater reduction in tumor size compared to the treatment for less than 12 months (97±1% vs. 78±7%, P<0.05). These findings indicate that cabergoline treatment led to a significant and rapid reduction in serum prolactin concentrations and tumor size in patients with giant prolactinoma. Therefore, cabergoline represents an effective and well-tolerated treatment for invasive giant prolactinoma

The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications

The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (UPR). Although the UPR could initially serve adaptive purposes in conditions associated with higher cellular demands and after exposure to a range of pathophysiological insults, over time the UPR may become detrimental, thus contributing to neuroprogression. Herein, we propose that immune-inflammatory, neuro-oxidative, neuro-nitrosative, as well as mitochondrial pathways may reciprocally interact with aberrations in UPR pathways. Furthermore, ER stress may contribute to a deregulation in calcium homoeostasis. The common denominator of these pathways is a decrease in neuronal resilience, synaptic dysfunction and even cell death. This review also discusses how mechanisms related to ER stress could be explored as a source for novel therapeutic targets for neurodegenerative and neuroprogressive diseases. The design of randomised controlled trials testing compounds that target aberrant UPR-related pathways within the emerging framework of precision psychiatry is warranted

SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar.

BACKGROUND: Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population, who comprise 60% of the total population. This study aimed to assess ever and/or current infection prevalence in this population. METHODS: A cross-sectional population-based survey was conducted during July 26 to September 09, 2020, to assess both anti-SARS-CoV-2 positivity through serological testing and current infection positivity through polymerase chain reaction (PCR) testing. Associations with antibody and PCR positivity were identified through regression analyses. RESULTS: The study included 2641 participants, 69.3% of whom were <40 years of age. Anti-SARS-CoV-2 positivity was 55.3% (95% CI, 53.3%-57.3%) and was significantly associated with nationality, geographic location, educational attainment, occupation, and previous infection diagnosis. PCR positivity was 11.3% (95% CI, 9.9%-12.8%) and was significantly associated with nationality, geographic location, occupation, contact with an infected person, and reporting 2 or more symptoms. Infection positivity (antibody and/or PCR positive) was 60.6% (95% CI, 58.6%-62.5%). The proportion of antibody-positive CMWs who had a prior SARS-CoV-2 diagnosis was 9.3% (95% CI, 7.9%-11.0%). Only seven infections were ever severe, and only 1 was ever critical-an infection severity rate of 0.5% (95% CI, 0.2%-1.0%). CONCLUSIONS: Six in every 10 CMWs in Qatar have been infected, suggestive of reaching the herd immunity threshold. Infection severity was low, with only 1 in every 200 infections progressing to be severe or critical. Only 1 in every 10 infections had been previously diagnosed, which is suggestive of mostly asymptomatic or mild infections

Effects of growth regulators on the quality of tomato fruits

Relevance and methods. This study aimed to improve fruit set and plant performance to increase tomato productivity by studying the effect of plant growth regulators on tomato plants. A specific experiment has been carried out to study the effect of plant growth regulators Hemo bles active substances (850 g/kg) Humic Acid with applied doses (250, 500 and 700 ppm) and Magictone active substances (5-12.5 g/kg) naphthalene acetic acid and naphthalene acetamide with applied doses (250, 500 and 700 ppm) on growth and physiological characteristics of tomato plants (Big Beef F1). The experimental design was a Complete Randomized Blocks Design. Both Hemo bles and Magictone were applied three times (spraying on plants at 30 DAP, spraying on plants at 60 DAP and spraying on plants 90 DAP).Results. The obtained results showed that, Applying Humic Acid “Ener-850” had the highest significant fruit weight (137 g) during the two seasons. Also using “Magictone” had the highest significant Flowers number (48.1), Fruits Number (35.1), Flower Clusters number in the plant (13.6) and Fruits Number (54.6. while (Humic Acid) improved tomato fruit’s quality during improve Dry weight (75.1 g) of Arial parts, Ascorbic Acid, level of Vitamin C and Carotenoids contents (4.82 mg 100 g-1). The results were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s HSD test with α = 0.05 with the help of MINITAB (v. 19.0) program