7 research outputs found
Cav2.3 R-type calcium channels: from its discovery to pathogenic de novo CACNA1E variants: a historical perspective
Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
A reverse genetic approach identifies an ancestral frameshift mutation in RP1 causing recessive progressive retinal degeneration in European cattle breeds
An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior
Cancer- and behavior-related genes are targeted by selection in the Tasmanian devil (Sarcophilus harrisii)
Targeting voltage-gated calcium channels in neurological and psychiatric diseases
Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors