Antarctic surface hydrology and impacts on ice-sheet mass balance

Melting is pervasive along the ice surrounding Antarctica. On the surface of the grounded ice sheet and floating ice shelves, extensive networks of lakes, streams and rivers both store and transport water. As melting increases with a warming climate, the surface hydrology of Antarctica in some regions could resemble Greenland’s present-day ablation and percolation zones. Drawing on observations of widespread Antarctica surface water and decades of study in Greenland, we consider three modes by which meltwater could impact Antarctic mass balance: increased runoff, meltwater injection to the bed, and meltwater-induced ice-shelf fracture, all of which may contribute to future ice sheet mass loss from Antarctica

Taboo Or Not Taboo: (In)visibilities Of Death, Dying And Bereavement

The notion that ‘death is a taboo’ pervades private, public and academic discourses around death, dying and bereavement in contemporary Western societies. The rise of digital media within the last decades further complicates the appreciation of the stance that death is a taboo, given the increased opportunities afforded in social media environments for embracing death, fostering new intimacies with strangers and semi-strangers but also for turning death into a spectacle (Jakobsen, 2016). The study of death-related practices online and the tensions they raise has rapidly been growing in the interdisciplinary field of Death online studies. However, in this field there is a need for developing shared conceptual and analytical frameworks and ensure methodological and theoretical robustness in line with developments in the study of social media communication. There is a need to synthesize insights from death sociology and interdisciplinary death online studies in order to shape an agenda for an integrated study of the offline and the online that can capture continuities and shifts in death-related practices (see also Borgstrom and Ellis, 2017). This panel collects four papers presented by six interdisciplinary scholars from Denmark, Sweden, Israel and the UK. Focusing on the (in)visibilities of death, dying and bereavement across contexts - online and offline - the papers critically revisit the ‘death is taboo’ thesis by investigating the particular conditions under which death, dying and bereavement are talked about, storied, and made socially visible and the ways in which technology plays a vital part in coping with mortality

Clavicular stress fracture in a cricket fast bowler: A case report

<p>Abstract</p> <p>Introduction</p> <p>Whilst rare, stress fractures of the clavicle have been described in other sports. To our knowledge, this is the first reported case of a stress fracture of the clavicle occurring in a cricket fast bowler.</p> <p>Case presentation</p> <p>A 23-year-old professional cricket fast bowler presented with activity related shoulder pain. Imaging demonstrated a stress fracture of the lateral third of the clavicle. This healed with rest and rehabilitation allowing a full return to professional sport.</p> <p>Conclusion</p> <p>This injury is treated with activity modification and technique adaptation. In a professional sportsman, this needs to be recognised early so that return to play can be as quick as possible.</p

A Sort of Permanence: Digital Remains and Posthuman Encounters with Death

Digital remains, in the shape of devices and traces of digital content and interaction stored on the devices them selves and online, left behind by the deceased have come to play important parts in the lives of those who live on. With a posthumanist perspective we explore how user-driven engagement with digital remains are changing and diversifying existing practices related to loss and grieving. The digital remains can be seen to contain the "essence" of the deceased person embodied within the digital device. Based on interviews and observations gathered from the contexts of Israel, the UK and Sweden, we investigate the role of digital remains in bereavement and what implications the eventual obsolescence of these remains might have for continuing bonds. In doing so we seek to increase our understanding of the (post)human encounter with death and the human capabilities of digital remains. digital remains, posthumanism, bereavement, continuing bonds. Abstract Keyword

Signal-Locality and Subquantum Information in Deterministic Hidden-Variables Theories

It is proven that any deterministic hidden-variables theory, that reproduces quantum theory for a 'quantum equilibrium' distribution of hidden variables, must predict the existence of instantaneous signals at the statistical level for hypothetical 'nonequilibrium ensembles'. This 'signal-locality theorem' generalises yet another feature of the pilot-wave theory of de Broglie and Bohm, for which it is already known that signal-locality is true only in equilibrium. Assuming certain symmetries, lower bounds are derived on the 'degree of nonlocality' of the singlet state, defined as the (equilibrium) fraction of outcomes at one wing of an EPR-experiment that change in response to a shift in the distant angular setting. It is shown by explicit calculation that these bounds are satisfied by pilot-wave theory. The degree of nonlocality is interpreted as the average number of bits of 'subquantum information' transmitted superluminally, for an equilibrium ensemble. It is proposed that this quantity might provide a novel measure of the entanglement of a quantum state, and that the field of quantum information would benefit from a more explicit hidden-variables approach. It is argued that the signal-locality theorem supports the hypothesis, made elsewhere, that in the remote past the universe relaxed to a state of statistical equilibrium at the hidden-variable level, a state in which nonlocality happens to be masked by quantum noise

A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies

A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells. Thus it is important to understand adhesion of cells by antibodies and similar molecules. We present an equilibrium model of such adhesion, incorporating heterogeneity in target cell epitope density and epitope immobility. We compare with experiments on the adhesion of Jurkat T cells to bilayers containing the relevant natural killer cell receptor, with adhesion mediated by the drug alefacept. We show that a model in which all target cell epitopes are mobile and available is inconsistent with the data, suggesting that more complex mechanisms are at work. We hypothesize that the immobile epitope fraction may change with cell adhesion, and we find that such a model is more consistent with the data. We also quantitatively describe the parameter space in which binding occurs. Our results point toward mechanisms relating epitope immobility to cell adhesion and offer insight into the activity of an important class of drugs.Comment: 13 pages, 5 figure

Safety of anti-immunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection

BACKGROUND: Although the role of immunoglobulin E (IgE) in immunity against helminth parasites is unclear, there is concern that therapeutic antibodies that neutralize IgE (anti-IgE) may be unsafe in subjects at risk of helminth infection. OBJECTIVE: We conducted an exploratory study to investigate the safety of omalizumab (anti-IgE) in subjects with allergic asthma and/or perennial allergic rhinitis at high risk of intestinal helminth infection. The primary safety outcome was risk of infections with intestinal helminths during anti-IgE therapy. METHODS: A randomized, double-blind, placebo-controlled trial was conducted in 137 subjects (12–30 years) at high risk of geohelminth infection. All subjects received pre-study anthelmintic treatment, followed by 52 weeks' treatment with omalizumab or placebo. RESULTS: Of the omalizumab subjects 50% (34/68) experienced at least one intestinal geohelminth infection compared with 41% (28/69) of placebo subjects [odds ratio (OR) 1.47, 95% confidence interval (CI) 0.74–2.95, one-sided P = 0.14; OR (adjusted for study visit, baseline infection status, gender and age) 2.2 (0.94–5.15); one-sided P = 0.035], providing some evidence for a potential increased incidence of geohelminth infection in subjects receiving omalizumab. Omalizumab therapy was well tolerated, and did not appear to be associated with increased morbidity attributable to intestinal helminths as assessed by clinical and laboratory adverse events, maximal helminth infection intensities and additional anthelmintic requirements. Time to first infection (OR 1.30, 95% CI 0.79–2.15, one-sided P = 0.15) was similar between treatment groups. Infection severity and response to anthelmintics appeared to be unaffected by omalizumab therapy. CONCLUSIONS: In this exploratory study of allergic subjects at high risk of helminth infections, omalizumab therapy appeared to be safe and well tolerated, but may be associated with a modest increase in the incidence of geohelminth infection

Effective problem solving using SAT solvers

In this article we demonstrate how to solve a variety of problems and puzzles using the built-in SAT solver of the computer algebra system Maple. Once the problems have been encoded into Boolean logic, solutions can be found (or shown to not exist) automatically, without the need to implement any search algorithm. In particular, we describe how to solve the $n$-queens problem, how to generate and solve Sudoku puzzles, how to solve logic puzzles like the Einstein riddle, how to solve the 15-puzzle, how to solve the maximum clique problem, and finding Graeco-Latin squares.Comment: To appear in Proceedings of the Maple Conference 201