14 research outputs found
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
Extraparenchymal neurocysticercosis: Demographic, clinicoradiological, and inflammatory features
Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
How much is enough? How multi-season exposure to demonstrations affects the use of conservation farming practices in Mozambique
Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2
Vesicles for transdermal delivery of peptides and proteins
Elastic vesicles have been developed and evaluated as novel topical and transdermal delivery systems. They are similar to conventional liposomes but with the incorporation of an edge activator in the lipid bilayer structure to provide elasticity. Elastic vesicles are applied non-occluded to the skin and have been shown to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. They have been investigated as drug carriers for a range of small molecules, peptides, proteins and vaccines, both in vitro and in vivo. Following topical application, structural changes in the stratum corneum have been identified and intact elastic vesicles visualised within the stratum corneum lipid lamellar regions, but no intact vesicles have been identified in the deeper viable tissues. Their method of transporting their drug payload into and through the skin has been investigated but remains an area of contention. This chapter provides an overview of the development of elastic vesicles for delivery into and via the skin