24 research outputs found
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- AntĂłn Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- AraĂșjo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
- Banerjee S
- Bao Y
- Baptista MS
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- Barbati C
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- Barlow PG
- Barmada SJ
- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
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- Basagoudanavar SH
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- Batten I
- Baulieu EE
- Baumgarner BL
- Bayry J
- Beale R
- Beau I
- Beaumatin F
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- Begun J
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- Beltran S
- Benbrook DM
- Bendorius M
- Benitez BA
- Benito-Cuesta I
- Bensalem J
- Berchtold MW
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- Bergamaschi D
- Bergami M
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- Berliocchi L
- Berlioz-Torrent C
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- Besirli CG
- Besteiro S
- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
- Bhattacharya S
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- Bhuiyan MS
- Bhutia SK
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- Bi X
- Biden TJ
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- Billes VA
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- Bonifacino JS
- Boone BA
- Bootman MD
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- Bornhauser BC
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- Bosch J
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- Bourgeois B
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- Bousquet G
- Boya P
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- Bozi LHM
- Bozkurt TO
- Brackney DE
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- Brandts CH
- Braun RJ
- Braus GH
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- Bravo-San Pedro JM
- Brest P
- Bringer M-A
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- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
- Bryson-Richardson RJ
- Bucci C
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- Buchan JR
- Buchrieser C
- Buckingham EM
- Budak H
- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- BurĂłn MI
- Bustos V
- Butturini E
- Byrd A
- BĂĄnrĂ©ti Ă
- BĂŒttner S
- Cabas I
- Cabrera-Benitez S
- Cadwell K
- Cai J
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- CairĂł M
- Calbet JA
- Caldwell GA
- Caldwell KA
- Call JA
- Calvani R
- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- CantĂ C
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- Caraglia M
- Caramés B
- Carchman EH
- Cardenal-Muñoz E
- Cardenas C
- Cardenas L
- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
- Carrier L
- Carroll B
- Carter AB
- Carvalho AN
- Casanova M
- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
- Chai C-Y
- Chakrabarti G
- Chakrabarti O
- Chakraborty T
- Chakraborty T
- Chami M
- Chamilos G
- Chan DW
- Chan ED
- Chan EYW
- Chan H
- Chan HH
- Chan HYE
- Chan MTV
- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
- Chen G-C
- Chen J-F
- Chen L
- Chen L
- Chen LL
- Chen M
- Chen M-K
- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- ChiurchiĂč V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- ColĂłn-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
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- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
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- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
- Dasari SK
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- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
- Davis T
- Dayalan Naidu S
- De Amicis F
- De Bosscher K
- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
- De Santi M
- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
- Di Guglielmo GM
- Di Leo L
- Di Malta C
- Di Nardo A
- Di Rienzo M
- Di Sano F
- Diallinas G
- Diao J
- Diaz-Araya G
- Dickinson JM
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- Dionne MS
- Distler JHW
- Diwan A
- Dixon IMC
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- Dobrovinskaya O
- Dobrowolski R
- Dobson RCJ
- Dokmeci Emre S
- Donadelli M
- Dong B
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- Dotsch V
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- Drucker L
- du Toit A
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- Dubrovska A
- Dunlop EA
- Dupont N
- DurĂĄn RV
- Dwarakanath BS
- Dyshlovoy SA
- DĂĄvila VA
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- Eckhart L
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- Emerling BM
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- Ferrante AW
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- Florance I
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- Yi-Ren Hong C-WH
- Yin X-M
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- Zambelli VO
- Zanella I
- Zang QS
- Zanivan S
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- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
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- Zhan L
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- Zhang KYB
- Zhang L
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- Zhang L
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- Zhang P
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao H
- Zhao L
- Zhao S
- Zhao T
- Zhao X-F
- Zhao Y
- Zhao Y
- Zhao Y
- Zhao Y
- Zheng G
- Zheng K
- Zheng L
- Zheng S
- Zheng X-L
- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
- Zhou A
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- Zhou X-J
- Zhou Y
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- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Recent advances in amyotrophic lateral sclerosis
- Author
- A Abraham
- A Al-Chalabi
- A Al-Chalabi
- A Blondet
- A Cannas
- A Cardenas-Blanco
- A Chio
- A Chio
- A Chio
- A Chio
- A Chio
- A Chio
- A Czaplinski
- A Freischmidt
- A Grimm
- A Hensiek
- A Jawaid
- A Montuschi
- A Pestronk
- A Truini
- A Valavanis
- A Wada
- AC Elden
- AC Lehn
- AE Renton
- Andersen PM Borasio GD, Dengler R, Hardiman O, Kollewe K, Leigh PN, Pradat PF, Silani V, Tomik B, Group EW
- Angelo Quattrini
- AV Strickland
- BJ Traynor
- BJ Traynor
- Brooks BR Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron D
- C Armon
- C Grunseich
- C Ingre
- C Lomen-Hoerth
- C Lomen-Hoerth
- C Munch
- C Pottier
- C Schuster
- C Tarlarini
- C Vance
- C York
- CA Munroe
- CA Young
- CH Wu
- Christian Lunetta
- D Daud
- D Lule
- D Lule
- D Testa
- DJ Berlowitz
- DJ Hensman Moss
- DR Rosen
- E Syriani
- EA Cats
- EJ Kasarskis
- F Fecto
- F Kimura
- F Seitzer
- Federica Agosta
- Filippi M Agosta F, Grosskreutz J, Benatar M, Kassubek J, Verstraete E, Turner MR, Neuroimaging Society in ALS
- FL Conforti
- FP Diekstra
- G Bensimon
- G Caiazzo
- G Ferrari
- G Floris
- G Marangi
- G Marrali
- G Pfeffer
- GM Ringholz
- H Cetin
- H Chen
- H Creemers
- H Daoud
- H Maruyama
- H Mitsumoto
- HD Katzberg
- I Puls
- J Dorst
- J Hrastelj
- J Keller
- J Phukan
- J Ravits
- J Ravits
- J Rooney
- J Senderek
- J Shaw
- J Sreedharan
- J Weis
- J Zhang
- JA Allen
- JC Desport
- JC Desport
- JD Rohrer
- JM Belsh
- JM Shaw
- JM Vidal-Taboada
- JO Benditt
- JO Johnson
- Johnson JO Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, Consortium I, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chio A, Traynor BJ
- JP Berg Van den
- K Boelmans
- K Hemminki
- K Mori
- K Nuytemans
- L Dupuis
- L Lacomblez
- L Ng
- L Sarro
- L Tremolizzo
- L Vlam
- LP Greenaway
- M Amador Mdel
- M Boentert
- M Carvalho de
- M DeJesus-Hernandez
- M Elamin
- M Elamin
- M Elamin
- M Maessen
- M Neumann
- M Schabhuttl
- M Seelen
- M Zimon
- MA Aguila del
- MA Es van
- MA Hellmann
- Majounie E Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chio A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, Chromosome ALSFTDC, French research network on FFA, Consortium I, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering-Brown S, Traynor BJ
- Massimo Filippi
- MC Kiernan
- Miller RG Jackson CE, Kasarskis EJ, England JD, Forshew D, Johnston W, Kalra S, Katz JS, Mitsumoto H, Rosenfeld J, Shoesmith C, Strong MJ, Woolley SC, Quality Standards Subcommittee of the American Academy of N
- MN Weedon
- MP Mattson
- MR Turner
- MR Turner
- MR Turner
- N Riva
- N Riva
- NG Simon
- Nilo Riva
- O Dols-Icardo
- P Menon
- Pensato V Tiloca C, Corrado L, Bertolin C, Sardone V, Del Bo R, Calini D, Mandrioli J, Lauria G, Mazzini L, Querin G, Ceroni M, Cantello R, Corti S, Castellotti B, Solda G, Duga S, Comi GP, Cereda C, Soraru G, DâAlfonso S, Taroni F, Shaw CE, Landers JE, Ticozzi N, Ratti A, Gellera C, Silani V, Consortium S
- PH Gordon
- ProGas Study G
- Pupillo E Messina P, Giussani G, Logroscino G, Zoccolella S, Chio A, Calvo A, Corbo M, Lunetta C, Marin B, Mitchell D, Hardiman O, Rooney J, Stevic Z, Bandettini di Poggio M, Filosto M, Cotelli MS, Perini M, Riva N, Tremolizzo L, Vitelli E, Damiani D, Beghi E, Consortium E
- Pupillo E Messina P, Logroscino G, Zoccolella S, Chio A, Calvo A, Corbo M, Lunetta C, Micheli A, Millul A, Vitelli E, Beghi E, Consortium E
- PWC Di
- Q Wei
- R Adolphs
- R Capozzo
- R Gregory
- R Rademakers
- R Reich-Slotky
- R Spataro
- R Steinbach
- Renton AE Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Holtta-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chio A, Restagno G, Borghero G, Sabatelli M, Consortium I, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ
- RJ Davenport
- RM Ahmed
- Rosenbohm A Kassubek J, Weydt P, Marroquin N, Volk AE, Kubisch C, Huppertz HJ, Weber M, Andersen PM, Weishaupt JH, Ludolph AC, Group ALSSR
- S Bannwarth
- S Connolly
- S Schmidt
- S Vucic
- SC Bourke
- Smith BN Ticozzi N, Fallini C, Gkazi AS, Topp S, Kenna KP, Scotter EL, Kost J, Keagle P, Miller JW, Calini D, Vance C, Danielson EW, Troakes C, Tiloca C, Al-Sarraj S, Lewis EA, King A, Colombrita C, Pensato V, Castellotti B, de Belleroche J, Baas F, ten Asbroek AL, Sapp PC, McKenna-Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Perez J, Munoz-Blanco JL, Simpson M, Consortium S, van Rheenen W, Diekstra FP, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Soraru G, Morrison KE, Williams KL, Nicholson GA, Blair IP, Dion PA, Leblond CS, Rouleau GA, Hardiman O, Veldink JH, van den Berg LH, Al-Chalabi A, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, Garcia-Redondo A, Wu Z, Glass JD, Gellera C, Ratti A, Brown RH Jr., Silani V, Shaw CE, Landers JE
- T Burke
- T Lee
- T Sevilla
- TF Gendron
- TJ Kwiatkowski Jr
- TJ Watermeyer
- VS Kostic
- Y Chen
- Y Iguchi
- YT Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Putting All the Pieces Together: Clinical, Macroscopic and Microscopic Characteristics of Subacute Thyroiditis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model
- Author
- A DiAntonio
- A Manno
- A Southon
- AC Groth
- AH Brand
- Ann-Shyn Chiang
- B DeLaBarre
- C Moreau-Fauvarque
- C Rabouille
- C Song
- CC Weihl
- CC Weihl
- CC Weihl
- Chia-Lin Wu
- CL Wu
- CU HĂŒbbers
- D Halawani
- D Halawani
- DJ Pagliarini
- E Jarosch
- E Tresse
- G Dietzl
- GD Watts
- George R. Jackson
- GP Ritson
- H Kondo
- H Yang
- HD Ryoo
- Henry C. Chang
- HH Meyer
- I Rouiller
- J Bilen
- J van der Zee
- J Vesa
- JE Niven
- JL Marsh
- JM Davies
- JM Warrick
- JS Ju
- JS Ju
- K Cao
- K Uchiyama
- L Guarente
- LM Redman
- M Hetzer
- M Latterich
- M Pintér
- Q Wang
- RM Dai
- SE Knowles
- SG Jacobson
- SR Schwarze
- T Koana
- T Kobayashi
- T Ogura
- T Stojkovic
- TK Sang
- TK Sang
- Tzu-Kang Sang
- UB Pandey
- V Menéndez-Benito
- VE Kimonis
- W Lieberthal
- Wan-Tzu Hung
- Wayne N. Frankel
- X Zhang
- Y Ye
- Ya-Chu Chang
- Yun-Chin Chang
- Publication venue
- Public Library of Science
- Publication date
- 01/02/2011
- Field of study
Inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) is caused by mutations in Valosin-containing protein (VCP), a hexameric AAA ATPase that participates in a variety of cellular processes such as protein degradation, organelle biogenesis, and cell-cycle regulation. To understand how VCP mutations cause IBMPFD, we have established a Drosophila model by overexpressing TER94 (the sole Drosophila VCP ortholog) carrying mutations analogous to those implicated in IBMPFD. Expression of these TER94 mutants in muscle and nervous systems causes tissue degeneration, recapitulating the pathogenic phenotypes in IBMPFD patients. TER94-induced neurodegenerative defects are enhanced by elevated expression of wild-type TER94, suggesting that the pathogenic alleles are dominant active mutations. This conclusion is further supported by the observation that TER94-induced neurodegenerative defects require the formation of hexamer complex, a prerequisite for a functional AAA ATPase. Surprisingly, while disruptions of the ubiquitin-proteasome system (UPS) and the ERâassociated degradation (ERAD) have been implicated as causes for VCPâinduced tissue degeneration, these processes are not significantly affected in our fly model. Instead, the neurodegenerative defect of TER94 mutants seems sensitive to the level of cellular ATP. We show that increasing cellular ATP by independent mechanisms could suppress the phenotypes of TER94 mutants. Conversely, decreasing cellular ATP would enhance the TER94 mutant phenotypes. Taken together, our analyses have defined the nature of IBMPFDâcausing VCP mutations and made an unexpected link between cellular ATP level and IBMPFD pathogenesis
Hypothalamic dysfunction following whole-brain irradiation
- Author
- Alan LaRocque
- Aschoff J
- Bardin CW
- Boldrey E
- Brodie TD
- Brown GM
- Cooper DS
- Corkill G
- De Lange WE
- Eskes GA
- Fike JR
- Fingert HJ
- Fogel TD
- Fred H. Hochberg
- Freeman JE
- Frier BM
- Hochberg FH
- Hochberg FH
- Jeffrey I. Mechanick
- Krieger DT
- Lachelin GCL
- Larkins RG
- Meadows AT
- Mindham RHS
- Ramsay DJ
- Richards GE
- Samaan NA
- Selmanoff M
- Shalet SM
- Spunberg JJ
- Tan BC
- Tobias CA
- Weihl AC
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Subacute thyroiditis and acute suppurative thyroiditis
- Author
- A Bindra
- A Jacobs
- A Miyauchi
- AA Alfadda
- AC Weihl
- AP Farwell
- BS Kim
- CA Benbassat
- DP Trivedi
- DS Ross
- E Martino
- E Mazza
- EH Yu
- EN Pearce
- F de Quervain
- H Falhammar
- H Masuoka
- J Görges
- J Sato
- JE Paes
- JH Lazarus
- JV Hennessey
- LB Sweeney
- M Dugar
- M Kawanaka
- M Stasiak
- M Stasiak
- MC Frates
- MD Herndon
- ME Sencar
- N Al-Dajani
- R Desailloud
- R Lamichaney
- R Volpé
- R Volpé
- S Iwama
- S Kubota
- SA Berger
- SH Golden
- SY Park
- V Chrobok
- V Fatourechi
- X Chen
- Y Matsumoto
- YJ Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Peripheral neuropathy, myelopathy, cerebellar ataxia, and subclinical optic neuropathy associated with copper deficiency occurring 23 years after total gastrectomy
- Author
- Allred JW Aulino JM
- Di Donato I Bianchi S, Federico A
- Ernst B Thurnheer M, Schultes B
- Everett CM Matharu M, Gawler J
- Goodman BP Bosch EP, Ross MA, et a
- Goodman BP Chong BW, Patel AC, et
- Henri-Bhargava A Melmed C, Glikste
- Howell JM Davidson AN
- Juhasz-Pocsine K Rudnicki SA, Arch
- Kumar N
- Kumar N Gross JB, Ahlskog JE
- Mariotti C Gellera C, Rimoldi M, e
- MIKI HIROKAZU
- MUKAI YOHEI
- Naismith RT Shepherd JB, Weihl CC,
- Nations SP Boyer PJ, Love LA, et a
- Prodan CI Bottomley SS, Vincent AS
- Prodan CI Holland NR, Wisdom PJ, e
- Schleper B Stuerenburg HJ
- Spinazzi M De Lazzari F, Tavolato
- Tan JC Burns DL, Jones HR
- Tan N Urich H
- Ueda N Suzuki Y, Rino Y, et al
- UEDA NAOHISA
- WAKUGAMI KIYOSHI
- Zara G Grassivaro F, Brocadello F,
- Publication venue
- 'Societas Neurologica Japonica'
- Publication date
- 01/01/2011
- Field of study
TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology
- Author
- Acharya KK
- Alexianu ME
- Arai T
- Ash PE
- Ayala YM
- Ayala YM
- Ayala YM
- Benajiba L
- Benatar M
- Bilen J
- Boillee S
- Borchelt DR
- Borroni B
- Bose JK
- Bruijn LI
- Buratti E
- Buratti E
- Cairns NJ
- Caroni P
- Chen-Plotkin AS
- Chiang PM
- Davidson Y
- Deng HX
- Dupuis L
- Elden AC
- Feiguin F
- Feng G
- Fiesel FC
- Fuentealba RA
- Geser F
- Gitcho MA
- Gitcho MA
- Gurney ME
- Hanson KA
- Higashi S
- Iga Wegorzewska
- Igaz LM
- Iguchi Y
- Ince PG
- Jaarsma D
- Johnson BS
- Jonsson PA
- Josephs KA
- Kabashi E
- Kawamata T
- Kim SH
- Kovacs GG
- Kraemer BC
- Kreutzberg GW
- Kwiatkowski
- Lagier-Tourenne C
- Leigh PN
- Li Y
- Ling SC
- Lobsiger CS
- Lomen-Hoerth C
- Lorson CL
- Lu Y
- Magrane J
- Mayford M
- Moisse K
- Murphy J
- Neumann M
- Reaume AG
- Ritson GP
- Robert H. Baloh
- Rosen DR
- Rothstein JD
- Schwab C
- Seeley WW
- Sephton CF
- Shan X
- Siddique T
- Sreedharan J
- Stallings NR
- Tsai KJ
- Turner BJ
- Van Deerlin VM
- Vance C
- Vidal M
- Wang J
- Wegorzewska I
- Weihl CC
- Wils H
- Winklhofer KF
- Wu LS
- Xu YF
- Yokoseki A
- Zhang YJ
- Zhou H
- Publication venue
- S. Karger AG
- Publication date
- 01/01/2011
- Field of study
The clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) suggests these diseases share common underlying mechanisms, a suggestion underscored by the discovery that TDP-43 inclusions are a key pathologic feature in both ALS and FTLD. This finding, combined with the identification of TDP-43 mutations in ALS, directly implicates this DNA/RNA binding protein in disease pathogenesis in ALS and FTLD. However, many key questions remain, including what is the normal function of TDP-43, and whether disease-associated mutations produce toxicity in the nucleus, cytoplasm or both. Furthermore, although pathologic TDP-43 inclusions are clearly associated with many forms of neurodegeneration, whether TDP-43 aggregation is a key step in the pathogenesis in ALS, FTLD and other disorders remains to be proven. This review will compare the features of numerous recently developed animal models of TDP-43-related neurodegeneration, and discuss how they contribute to our understanding of the pathogenesis of human ALS and FTLD
Ongoing Developments in Sporadic Inclusion Body Myositis
- Author
- A Cortese
- A Hernandez Lain
- A Hiniker
- A Nogalska
- A Oldfors
- A Oldfors
- A Rojana-udomsart
- AA Amato
- AA Amato
- AC McPherron
- AC McPherron
- AL Mammen
- AM Haidet
- Amanda C. Wallace
- American Thoracic Society - ATS American College of Chest Physicians - ACCP
- AP Scott
- AP Scott
- AP Scott
- AR Moslemi
- B Hernandez-Charro
- B Ranque-Francois
- BA Phillips
- BA Phillips
- BM Koffman
- C Cantwell
- C DâAgostino
- C DâAgostino
- C Lindberg
- C McFarlane
- CC Weihl
- CC Weihl
- CD Reimers
- D Hilton-Jones
- DS Mosher
- EA Sekul
- Estelle Healy
- F Girolamo
- FC Wilson
- FL Mastaglia
- FL Mastaglia
- FM Cox
- FM Santorelli
- G Carnac
- G Vattemi
- GC Minetti
- GF Wiesinger
- GH Glover
- Gita Ramdharry
- H Cai
- H Pluk
- HB Larman
- HD Kollias
- Henry Houlden
- HK Lee
- HW Kohl
- I Ferrer
- J Lampe
- J Morrow
- J Nalbantoglu
- JA Johnston
- JA Tan
- Janice L. Holton
- Jasper M. Morrow
- JB Lampe
- JL Pinkus
- JS Ju
- K Arahata
- K Jones
- K Jurkat-Rott
- K Sivakumar
- K Sivakumar
- KJ Felice
- KR Wagner
- L Alemo Munters
- LG Johnson
- Linda Greensmith
- Liz Dewar
- LP Lowes
- LR Rodino-Klapac
- M Bartoli
- M Breithaupt
- M Cacciottolo
- M Needham
- M Needham
- M Needham
- M Needham
- M Olive
- M Orth
- M Phillips
- M Salajegheh
- M Salajegheh
- M Schuelke
- M Tateyama
- MA McCrory
- Matthew Parton
- MC Dalakas
- Mhoriam Ahmed
- Michael G. Hanna
- MJ Garlepp
- MM Dimachkie
- MP Wattjes
- MR Rose
- N Suzuki
- O Benveniste
- O Benveniste
- O Kaipiainen-Seppanen
- P Fratta
- P Machado
- P Machado
- P Price
- P Temiz
- Pedro M. Machado
- Q Gang
- Qiang Gang
- R Kambadur
- RC Griggs
- RJ Guerreiro
- RW Georgantas
- S Arnardottir
- S Bogdanovich
- S Brady
- S Brady
- S Lezzi
- S Nakano
- S Wojcik
- SA Greenberg
- SA Greenberg
- SA Greenberg
- SA Greenberg
- SA Spector
- SM Cadena
- SP Ringel
- Stefen Brady
- T Taivassalo
- TE Lloyd
- TP OâHanlon
- UA Badrising
- UA Badrising
- V Askanas
- V Askanas
- V Askanas
- V Askanas
- Y Liu
- YP Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation
- Author
- A Kaus
- AC Wilson
- AK Walker
- AM Herman
- AS Correia
- B Bolognesi
- BS Johnson
- C Colombrita
- C MĂŒnch
- C Schwab
- CA Brunello
- CA Ross
- CC Weihl
- CF Tan
- DA Bosco
- DR Whiten
- DW Cleveland
- E Kabashi
- E Pokrishevsky
- EL Scotter
- EV Ilieva
- F Chiti
- H Nakashima-Yasuda
- H Nishitoh
- H Suzuki
- HY Chang
- IR Mackenzie
- Isabella A. Lambert-Smith
- J Sreedharan
- JD Atkin
- JD Atkin
- JD Atkin
- Justin J. Yerbury
- K Forsberg
- K Roberts
- L Banci
- L Liu-Yesucevitz
- L McAlary
- L McAlary
- M Neumann
- M Neumann
- MJ Lindberg
- Natalie E. Farrawell
- NE Farrawell
- NJ Cairns
- NR Cashman
- PM Andersen
- PN Leigh
- R Zeineddine
- R Zeineddine
- Rafaa Zeineddine
- S Polling
- S Saxena
- SB Prusiner
- SB Prusiner
- T Arai
- T Arai
- T Nonaka
- T Nonaka
- T Zhang
- V Sundaramoorthy
- X Shan
- Y Davidson
- Y Toyoshima
- YJ Zhang
- YS Davidson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study