The human keratins: biology and pathology

The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed in highly specific patterns related to the epithelial type and stage of cellular differentiation. About half of all keratins—including numerous keratins characterized only recently—are restricted to the various compartments of hair follicles. As part of the epithelial cytoskeleton, keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Moreover, some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. Applying the new consensus nomenclature, this article summarizes, for all human keratins, their cell type and tissue distribution and their functional significance in relation to transgenic mouse models and human hereditary keratin diseases. Furthermore, since keratins also exhibit characteristic expression patterns in human tumors, several of them (notably K5, K7, K8/K18, K19, and K20) have great importance in immunohistochemical tumor diagnosis of carcinomas, in particular of unclear metastases and in precise classification and subtyping. Future research might open further fields of clinical application for this remarkable protein family

Remote sensing contributing to assess earthquake risk: from a literature review towards a roadmap

Remote sensing data and methods are widely deployed in order to contribute to the assessment of numerous components of earthquake risk. While for earthquake hazardrelated investigations, the use of remotely sensed data is an established methodological element with a long research tradition, earthquake vulnerability–centred assessments incorporating remote sensing data are increasing primarily in recent years. This goes along with a changing perspective of the scientific community which considers the assessment of vulnerability and its constituent elements as a pivotal part of a comprehensive risk analysis. Thereby, the availability of new sensors systems enables an appreciable share of remote sensing first. In this manner, a survey of the interdisciplinary conceptual literature dealing with the scientific perception of risk, hazard and vulnerability reveals the demand for a comprehensive description of earthquake hazards as well as an assessment of the present and future conditions of the elements exposed. A review of earthquake-related remote sensing literature, realized both in a qualitative and quantitative manner, shows the already existing and published manifold capabilities of remote sensing contributing to assess earthquake risk. These include earthquake hazard-related analysis such as detection and measurement of lineaments and surface deformations in pre- and post-event applications. Furthermore, pre-event seismic vulnerability–centred assessment of the built and natural environment and damage assessments for post-event applications are presented. Based on the review and the discussion of scientific trends and current research projects, first steps towards a roadmap for remote sensing are drawn, explicitly taking scientific, technical, multi- and transdisciplinary as well as political perspectives into account, which is intended to open possible future research activities