Automated server-side model for recognition of security vulnerabilities in scripting languages

With the increase of global accessibility of web applications, maintaining a reasonable security level for both user data and server resources has become an extremely challenging issue. Therefore, static code analysis systems can help web developers to reduce time and cost. In this paper, a new static analysis model is proposed. This model is designed to discover the security problems in scripting languages. The proposed model is implemented in a prototype SCAT, which is a static code analysis Tool. SCAT applies the phases of the proposed model to catch security vulnerabilities in PHP 5.3. Empirical results attest that the proposed prototype is feasible and is able to contribute to the security of real-world web applications. SCAT managed to detect 94% of security vulnerabilities found in the testing benchmarks; this clearly indicates that the proposed model is able to provide an effective solution to complicated web systems by offering benefits of securing private data for users and maintaining web application stability for web applications providers

Anatomical variations of hepatic artery using the multidetector computed tomography angiography

Background: The frequency of normal and aberrant hepatic arteries differs among ethnicities. The aim of our work was to study the frequency of normal and aberrant hepatic arteries among Egyptians using multidetector computed tomography (MDCT) and to compare our prevalence with the prevalence of other nationalities. In addition, the gender differences of such variations were clarified. Moreover, the arterial feeding of hepatic segment IV was determined. Materials and methods: The present study was carried out on 500 patients (409 males and 91 females). Abdominal CT was performed using two MDCT systems, a 64-row, and a 256-slice system. Results: According to Michel’s classification, the normal anatomy (type I) was observed in 369 (73.8%) cases, while anomalous hepatic arterial pattern was detected in 131 (26.2%) cases. These anomalies were distributed as follows: type II in 36 (7.2%) cases, type III in 60 (12%) cases, types IV and V in 5 cases for each (1% each), type VI in 14 (2.8%) and types VIII and IX in a single case for each (0.2% each). Neither type VII nor type X was detected. Nine (1.8%) unclassified cases were observed. According to Hiaat’s classification, the anomalies were distributed as follows: type II in 41 (8.2%) cases, type III in 74 (14.8%) cases, type IV in 6 (1.2%) cases, type V in a single case (0.2%) and type VI in 2 (0.4%) cases. Finally, 7 (1.4%) unclassified cases were observed. Common hepatic artery (CHA) originated from coeliac trunk in 98% (79.8% males and 18.2% females). It originated from the abdominal aorta in 0.4% and from the superior mesenteric artery (SMA) in 0.4%. It was absent in 1.2%. Right hepatic artery (RHA) originated from the CHA in 86.6% (69.8% males and 16.8% females) and from the SMA in 13.2% (11.8% males and 1.4% females) and from the abdominal aorta in 0.2% (a single male case). Left hepatic artery (LHA) originated from the CHA in 91.2% and from the left gastric artery (LGA) in 8.8%. The most common origin of the segment IV blood supply was the LHA in 60.8%, followed by the RHA in 35%. Less commonly, blood supply derived from the hepatic artery proper (HAP) in 1%. Combined supply derived from RHA and LHA in 0.8%, from the LHA and HAP in 2% and the least encountered was from the RHA and HAP in 0.4%. Conclusions: Hepatic artery variations among Egyptians have a different distribution when compared to such variations among other species. The normal hepatic arterial pattern was observed in 73.8%, while the anomalous was detected in 26.2%. The CHA originated from the coeliac trunk in 98%, the RHA originated from the CHA in 86.6% and the LHA originated from the CHA in 91.2%. The most common arterial supply of the hepatic segment IV is derived from the LHA (60.2%)

A new improved Stability-Indicating RP-HPLC method for Determination of Diosmin and hesperidin in combination

Abstrac

Hématomes Extraduraux Chez L’adulte Au Togo

Purpose: The purpose of this work was to evaluate our neurosurgical practice about extradural hematoma and to describe their prognosis in our context. Patients and methods: This is a retrospective study of patients treated for extradural hematoma at Sylvanus Olympio university teaching hospital, which houses the only neurosurgery unit in Togo between April 2008 and August 2014. We included in our study, the files of patients of both sexes, aged over 15 years, with extradural hematoma isolated or not at the cerebral scanner, treated during the study period. Thus, 62 patients were taken into account. There was a male predominance (sex ratio of 19.7). The average age was 29.8 years with extremes of 02 and 70 years of which 41.9% of patients were between 20 and 29 years old. The surgical technique was the making of a burr hole or a cranial flap. We examined the parameters related to surgical treatment and the evolutionary mode. Results: In this study, 34 patients (54.8%) underwent surgery: cranial section (27 cases), widened hole craniotomy (07 cases). The average time between trauma and surgery was 09 days with extremes of 01 to 30 days. Twenty-four patients were operated more than 48 hours after diagnosis and the average postoperative follow-up time was 11.1 days with extremes of 07 and 18 days. Twenty-eight patients (45.2%) were not operated on. Among them, 20 patients presented with a HED blade (thickness of less than 10mm) and the eight (08) others for lack of financial means. The average hospital follow-up time for non-operated patients was 15.4 days with extremes of 08 and 60 days. The evolution was evaluated by the Glasgow Outcome Scale over three months. Fifty-five patients or 88.7% recovered without sequel. We obtained 3 cases (4.8%) of deaths including 2 cases that were not operated due to lack of financial means. Conclusion: We have observed that a low Glasgow admission score, long treatment delays, and associated lesions are factors that appear to reduce the prognosis in the treatment of extradural hematoma in Togo. These prognostic factors must be better documented in our future studies to identify them in order to act on them in order to reduce the morbidity and mortality that these extra-mural hematoma cause in our environments

Ecological momentary assessment of fatigue, sleepiness, and exhaustion in ESKD

Background: Many patients on maintenance dialysis experience significant sleepiness and fatigue. However, the influence of the hemodialysis (HD) day and circadian rhythms on patients' symptoms have not been well characterized. We sought to use ecological momentary assessment to evaluate day-to-day and diurnal variability of fatigue, sleepiness, exhaustion and related symptoms in thrice-weekly maintenance HD patients. Methods. Subjects used a modified cellular phone to access an interactive voice response system that administered the Daytime Insomnia Symptom Scale (DISS). The DISS assessed subjective vitality, mood, and alertness through 19 questions using 7- point Likert scales. Subjects completed the DISS 4 times daily for 7 consecutive days. Factor analysis was conducted and a mean composite score of fatigue-sleepiness- exhaustion was created. Linear mixed regression models (LMM) were used to examine the association of time of day, dialysis day and fatigue, sleepiness, and exhaustion composite scores. Results: The 55 participants completed 1,252 of 1,540 (81%) possible assessments over the 7 day period. Multiple symptoms related to mood (e.g., feeling sad, feeling tense), cognition (e.g., difficulty concentrating), and fatigue (e.g., exhaustion, feeling sleepy) demonstrated significant daily and diurnal variation, with higher overall symptom scores noted on hemodialysis days and later in the day. In factor analysis, 4 factors explained the majority of the observed variance for DISS symptoms. Fatigue, sleepiness, and exhaustion loaded onto the same factor and were highly intercorrelated. In LMM, mean composite fatigue-sleepiness-exhaustion scores were associated with dialysis day (coefficient and 95% confidence interval [CI] 0.21 [0.02 - 0.39]) and time of day (coefficient and 95% CI 0.33 [0.25 - 0.41]. Observed associations were minimally affected by adjustment for demographics and common confounders. Conclusions: Maintenance HD patients experience fatigue-sleepiness-exhaustion symptoms that demonstrate significant daily and diurnal variation. The variability in symptoms may contribute to poor symptom awareness by providers and greater misclassification bias of fatigue related symptoms in clinical studies. © 2014 Abdel-Kader et al.; licensee BioMed Central Ltd

Pycnogenol® and Ginkgo biloba extract: effect on peroxynitrite-oxidized sarcoplasmic reticulum Ca2+-ATPase

The effect of two natural standardized plant extracts, Pycnogenol® and EGb 761, on sarcoplasmic reticulum Ca2+-ATPase (SERCA) activity and posttranslational modifications induced by peroxynitrite was investigated to assess their possible protective role. EGb 761 was found to have a protective effect on SERCA activity in the concentration range of 5–40 µg/ml. On the other hand, Pycnogenol® caused a decrease of SERCA activity at concentrations of 25 µg/ml. EGb 761 did not prevent protein carbonyl formation upon oxidation with peroxynitrite. On the contrary, Pycnogenol® at the concentrations of 5 and 10 µg/ml significantly decreased the level of protein carbonyls by 44% and 54%, respectively. Neither Pycnogenol® nor EGb 761 exerted a protective effect against thiol group oxidation.The plant extracts studied modulated peroxynitrite-injured SERCA activity by different ways and failed to correlate with posttranslational modifications. Their effect seems to be associated with their ability to change SERCA conformation rather than by their antioxidant capacity

Ginkgo Biloba Extract Ameliorates Oxidative Phosphorylation Performance and Rescues Aβ-Induced Failure

Energy deficiency and mitochondrial failure have been recognized as a prominent, early event in Alzheimer's disease (AD). Recently, we demonstrated that chronic exposure to amyloid-beta (Abeta) in human neuroblastoma cells over-expressing human wild-type amyloid precursor protein (APP) resulted in (i) activity changes of complexes III and IV of the oxidative phosphorylation system (OXPHOS) and in (ii) a drop of ATP levels which may finally instigate loss of synapses and neuronal cell death in AD. Therefore, the aim of the present study was to investigate whether standardized Ginkgo biloba extract LI 1370 (GBE) is able to rescue Abeta-induced defects in energy metabolism