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Synergistic inhibition of melanoma xenografts by Brequinar sodium and Doxorubicin

Malignant melanoma continues to be a fatal disease for which novel and long-term curative breakthroughs are desired. One such innovative idea would be to assess combination therapeutic treatments – by way of combining two potentially effective and very different therapy. Previously, we have shown that DHODH inhibitors, A771726 and Brequinar sodium (BQR) induced cell growth impairment in melanoma cells. Similar results were seen with DHODH RNA interference (shRNA). In the present study, we showed that combination of BQR with doxorubicin resulted in synergistic and additive cell growth inhibition in these cells. In addition, in vivo studies with this combination of drugs demonstrated an almost 90% tumor regression in nude mice bearing melanoma tumors. Cell cycle regulatory proteins, cyclin B1 and its binding partner pcdc-2 and p21 were significantly downregulated and upregulated respectively following the combined treatment. Given that we have observed synergistic effects with BQR and doxorubicin, both in vitro and in vivo, these drugs potentially represent a new combination in the targeted therapy of melanoma

PEPPER LEAF CURL VIRUS RESISTANCE IN CHILLI

Not AvailableIn order to study inheritance of PepLCV, Punjab Lal, was crossed with highly susceptible line PBC-535 during 2007-08. The mature buds of the plants were chosen from the female line and emasculated carefully using forceps. Manual pollination on emasculated buds was practiced without causing any damage to the stigma. The pollinated buds were covered with cotton and labeled using crossing tags. A total of 20 plants of the F1 and each parents were transplanted in field in three replications for confirmation of disease incidence. In glasshouse condition a total of 30 plants of the F1 and 10 of parents were transplanted in pots and reaction against PepLCV was examined.Not Availabl

Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy

Development of advanced surgical tools for minimally invasive procedures represents an activity of central importance to improvements in human health. A key materials challenge is in the realization of bio-compatible interfaces between the classes of semiconductor and sensor technologies that might be most useful in this context and the soft, curvilinear surfaces of the body. This paper describes a solution based on biocompatible materials and devices that integrate directly with the thin elastic membranes of otherwise conventional balloon catheters, to provide multimodal functionality suitable for clinical use. We present sensors for measuring temperature, flow, tactile, optical and electrophysiological data, together with radio frequency (RF) electrodes for controlled, local ablation of tissue. These components connect together in arrayed layouts designed to decouple their operation from large strain deformations associated with deployment and repeated inflation/deflation. Use of such ‘instrumented’ balloon catheter devices in live animal models and in vitro tests illustrates their operation in cardiac ablation therapy. These concepts have the potential for application in surgical systems of the future, not only those based on catheters but also on other platforms, such as surgical gloves