Progress and challenges in the vaccine-based treatment of head and neck cancers

Head and neck (HN) cancer represents one of the most challenging diseases because the mortality remains high despite advances in early diagnosis and treatment. Although vaccine-based approaches for the treatment of advanced squamous cell carcinoma of the head and neck have achieved limited clinical success, advances in cancer immunology provide a strong foundation and powerful new tools to guide current attempts to develop effective cancer vaccines. This article reviews what has to be rather what has been done in the field for the development of future vaccines in HN tumours

Review of information systems research for media industry–recent advances, challenges, and introduction of information systems research in the media industry

Global media reports clearly show a tremendous increase in spending on Information Technology (IT) and Information Systems (IS) in the media sector. Two main trends are currently visible. First, as stated in McKinsey & Company’s Global Media Report, consumers continuously shift from spending on traditional media products towards rapidly-increasing spending on digital services and media products – consumer patterns have rapidly changed. Second, as stated in Gartner’s reports about the media industry, spending on IT services in the media industry increases gradually, and as a whole, the media industry is the third-largest spender on IT, after banking/finance and manufacturing. Third, as reported by both authors in their works, several facets of the media industry have undergone extreme changes, including business models, declining revenue, content models, management, economics and public funding. The aim of this study is to investigate research work related to IS in the media industry, in particular in the management and economic areas. To conduct this study, we investigated a large corpus of studies that have been contributed to IS research within the Association for Information Systems (AIS) within the past decades. We utilised advanced text mining methods to identify contributions and thematic areas. Our results clearly indicate that there is a significant downward trend of research works dealing with media industry aspects. This trend was a surprise to us, as it contradicts the emergence of new digital technologies which became key drivers in the media industry after 2009. We conclude this article by giving research directions, illustrating the opportunities and importance of investigating media industries within the context of IS, and introducing the research field of Information Systems in the eMedia Industry

Global media, business and politics: a comparative analysis of News Corporation’s strategy in Italy and the UK

This article presents a comparative analysis of News Corporation’s entry strategy and rise to dominance in the British and Italian television markets through its satellite pay-TV operations, BSkyB and Sky Italia respectively. As well documented, News Corporation’s strategy in the UK has been heavily dependent on Rupert Murdoch’s cultivation of political connections. By contrast, in Italy Murdoch has been unable to influence local politics to further his business interests, as evidenced by the several regulatory setbacks suffered by Sky Italia. Thus, in order to explain News Corporation’s success in Italy, this article argues that emphasis must be placed primarily on the managerial and financial resources that the company has been able to mobilize. The analysis aims at broadening our understanding of how News Corporation operates in different national contexts, and should also prove valuable for the broader question concerning the shifting balance of power between transnational and national actors in today’s globalizing media landscape