55 research outputs found
A Fluorescent Glycolipid-Binding Peptide Probe Traces Cholesterol Dependent Microdomain-Derived Trafficking Pathways
10.1371/journal.pone.0002933PLoS ONE38
The multiple faces of self-assembled lipidic systems
Lipids, the building blocks of cells, common to every living organisms, have the propensity to self-assemble into well-defined structures over short and long-range spatial scales. The driving forces have their roots mainly in the hydrophobic effect and electrostatic interactions. Membranes in lamellar phase are ubiquitous in cellular compartments and can phase-separate upon mixing lipids in different liquid-crystalline states. Hexagonal phases and especially cubic phases can be synthesized and observed in vivo as well. Membrane often closes up into a vesicle whose shape is determined by the interplay of curvature, area difference elasticity and line tension energies, and can adopt the form of a sphere, a tube, a prolate, a starfish and many more. Complexes made of lipids and polyelectrolytes or inorganic materials exhibit a rich diversity of structural morphologies due to additional interactions which become increasingly hard to track without the aid of suitable computer models. From the plasma membrane of archaebacteria to gene delivery, self-assembled lipidic systems have left their mark in cell biology and nanobiotechnology; however, the underlying physics is yet to be fully unraveled
Unilateral curved versus bipedicular vertebroplasty in the treatment of osteoporotic vertebral compression fractures
Innovating in the medical device industry – challenges & opportunities ESB 2015 translational research symposium
Nonunion of osteoporotic vertebral compression fracture with a severe spinal stenosis treated in minimally invasive manner: a case report
Were VCF patients at higher risk of mortality following the 2009 publication of the vertebroplasty “sham” trials?
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