5 research outputs found
Sentinel Node Procedure for Breast Cancer: training, safety, reliability and follow-up aspects
In the recent years the surgical treatment of breast cancer has changed towards a less
invasive and less mutilating procedure. Breast conserving therapy and the introduction of the
sentinel node (SN) procedure are the two most important changes. The introduction of a new
technique is a time consuming procedure. First it should be developed and evaluated in a local
situation. If the new technique is believed to be better than the standard treatment, the
technique should be come available if possible after a randomised controlled trial for all
patients concerned. In CHAPTER 2 the introduction of the SN procedure in three
participating hospitals (a large teaching hospital, a cancer centre and a university hospital) is
described. Special attention was made on the role of a co-ordinator to assure standardisation
and quality control in this multicenter study. The role of the co-ordinator was two folded;
firstly the supervision of the implementation in the several involved departments and secondly
to refine the procedure upon the collected data. During our study we adjusted several aspects
of the procedure: the concentration of the colloid in the radioactive solution, the injection of
the blue dye intracutaneously after disappointing results of the peritumoral injection and, in
cases of a preceding lumpectomy, a cranial injection to the scar because of failure of the
caudal injections. With these corrections the results became excellent.
In the end the results of the procedure (sensitivity and false negativity) were the same for the
three participating hospitals
Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation
Optimization of Radziszewski's four-component reaction employing a microwave-assisted protocol, led to a small library of 48 imidazoles with a success rate of 65% (conversion >45%). All three diversity points of the four-component reaction were varied. Aromatic and aliphatic inputs were successfully implemented and mono-, di-, tri- and tetrasubstituted imidazoles with various substitution patterns were synthesized. Furthermore, unsymmetrical diketones could successfully be used which improved the intrinsic diversity of the method significantly. If the unsymmetrical diketone 1,2-phenylpropanedione (