17 research outputs found
ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡ ΡΠ»ΠΎΠ²Π° ΠΊΠ°ΠΊ ΠΎΡΠ½ΠΎΠ²Π° ΡΠΈΠΏΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠ·ΡΠΊΠΎΠ²
The article deals with the language classification principles proceeding from their morphological features while studying Indo-European inflexion languages.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΈΠ½ΡΠΈΠΏΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ·ΡΠΊΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π½Π° ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΡΠ»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈΠ½Π΄ΠΎΠ΅Π²ΡΠΎΠΏΠ΅ΠΉΡΠΊΠΈΡ
ΡΠ·ΡΠΊΠΎΠ²
ΠΠ°ΡΠ΅Π³ΠΎΡΠΈΡ Π²ΠΎΠΊΠ°ΡΠΈΠ²Π° ΠΊΠ°ΠΊ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΠ―Π‘
This article represents the typological analysis of a vocative case category in some modern literary languages of Balkan Peninsula: the Bulgarian, Romanian, and Serbian and in some other modern Slavic literary languages.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΡ Π²ΠΎΠΊΠ°ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΡΡΠ΄Π΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π±Π°Π»ΠΊΠ°Π½ΡΠΊΠΈΡ
ΡΠ·ΡΠΊΠΎΠ² (Π±ΠΎΠ»Π³Π°ΡΡΠΊΠΈΠΉ, ΡΡΠΌΡΠ½ΡΠΊΠΈΠΉ, ΡΠ΅ΡΠ±ΡΠΊΠΈΠΉ ΡΠ·ΡΠΊΠΈ)
ΠΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΡ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π½Π΅Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ.
Currently, there has been a progressive increase in prevalence of one of the most common diffuse chronic liver diseases β non-alcoholic fatty liver disease (NAFLD). Assessment of the stages of liver fibrosis and steatosis is prognostically significant in diagnosis of NAFLD. Routine diagnostic methods are either not able to accurately assess the severity of fibrosis and steatosis (ultrasound, laboratory tests), or cannot be used as a simple screening tool (liver biopsy) due to such limitations as invasiveness, dependence on pathologist qualification, high cost, and limited region of interest. Over the last two decades, the great progress has been made in non-invasive visualization of pathological changes in liver diseases. In this review, we examined the diagnostic characteristics of the most widely used non-invasive imaging methods in clinical practice, available for quantitative determination of fat and fibrosis in the liver: transient elastography with controlled attenuation parameter (CAP), acoustic radiation force impulse (ARFI) and shear wave elastography (SWE). Comparing these methods and their limitations, we came to conclusion, that elastographic methods (slightly more ARFI and SWE) are able to verify the F3, F4 stages of fibrosis in NAFLD with high sensitivity and specificity (90%); however, they are less accurate for early stages. Elastographic techniques have moderate accuracy in identifying the degree of steatosis due to the lack of uniform standardized cut-off values of CAP.Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠΎΡΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· ΡΠ°ΠΌΡΡ
ΡΠ°ΡΡΠΎ Π²ΡΡΡΠ΅ΡΠ°ΡΡΠΈΡ
ΡΡ Π΄ΠΈΡΡΡΠ·Π½ΡΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ β Π½Π΅Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΡΠΈΡΠ°Π΅ΡΡΡ ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΠ°Π΄ΠΈΠΉ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΈ ΡΡΠ΅Π°ΡΠΎΠ·Π° ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠ±ΡΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π»ΠΈΠ±ΠΎ Π½Π΅ ΡΠΏΠΎΡΠΎΠ±Π½Ρ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΎΡΠ½ΠΎΡΡΡΡ ΠΎΡΠ΅Π½ΠΈΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΈ ΡΡΠ΅Π°ΡΠΎΠ·Π° (ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΡΠ΅ΡΡΡ), Π»ΠΈΠ±ΠΎ Π½Π΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΡΠΎΡΡΠΎΠ³ΠΎ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³Π° (Π±ΠΈΠΎΠΏΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ) Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΠ²ΠΎΠΈΡ
ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠΉ (ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΡΡΡ, Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΎΡ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³Π°, Π²ΡΡΠΎΠΊΠ°Ρ ΡΡΠΎΠΈΠΌΠΎΡΡΡ, ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΡΠΉ ΡΡΠ°ΡΡΠΎΠΊ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ). ΠΠ° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄Π²Π° Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ ΠΎΠ³ΡΠΎΠΌΠ½ΡΠ΅ ΡΡΠΏΠ΅Ρ
ΠΈ Π±ΡΠ»ΠΈ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΡ Π² Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΉ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΏΡΠΈ Π±ΠΎΠ»Π΅Π·Π½ΡΡ
ΠΏΠ΅ΡΠ΅Π½ΠΈ. Π ΡΡΠΎΠΌ ΠΎΠ±Π·ΠΎΡΠ΅ ΠΌΡ ΠΈΠ·ΡΡΠΈΠ»ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΠΈΡ
ΡΡ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π΄ΠΎΡΡΡΠΏΠ½ΡΡ
Π΄Π»Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΆΠΈΡΠ° ΠΈ ΡΠΈΠ±ΡΠΎΠ·Π° Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ: ΡΡΠ°Π½Π·ΠΈΠ΅Π½ΡΠ½ΡΡ ΡΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΡ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΡΠΌ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠΌ Π·Π°ΡΡΡ
Π°Π½ΠΈΡ (CAP), Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ°Π΄ΠΈΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ΅ Π΄Π°Π²Π»Π΅Π½ΠΈΠ΅, ΡΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΡ ΡΠ΄Π²ΠΈΠ³ΠΎΠ²ΡΡ
Π²ΠΎΠ»Π½. Π‘ΡΠ°Π²Π½ΠΈΠ²Π°Ρ Π²ΡΡΠ΅ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈ ΠΈΡ
ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΡ, ΠΌΡ ΠΏΡΠΈΡΠ»ΠΈ ΠΊ Π²ΡΠ²ΠΎΠ΄Ρ, ΡΡΠΎ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΡΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ (Π½Π΅ΠΌΠ½ΠΎΠ³ΠΎ Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ°Π΄ΠΈΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ΅ Π΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΠΈ ΡΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΡ ΡΠ΄Π²ΠΈΠ³ΠΎΠ²ΡΡ
Π²ΠΎΠ»Π½) ΡΠΏΠΎΡΠΎΠ±Π½Ρ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡΡ (90%) Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ F3-, F4-ΡΡΠ°Π΄ΠΈΠΈ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΏΡΠΈ Π½Π΅Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π½ΠΎ ΠΌΠ΅Π½Π΅Π΅ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Ρ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΡΠ°Π½Π½ΠΈΡ
ΡΡΠ°Π΄ΠΈΠΉ. Π‘ΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠ΅Π°ΡΠΎΠ·Π° ΡΠ°ΡΠΏΠΎΠ·Π½Π°ΡΡΡΡ Ρ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ ΡΠΎΡΠ½ΠΎΡΡΡΡ, ΡΡΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ Π΅Π΄ΠΈΠ½ΡΡ
ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎΡΠΎΠ³ΠΎΠ²ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ CAP
Long-term neurological and behavioral results of biodegradable scaffold implantation in mice brain
The aim of the study was to assess the integral outcomes of implantation biocompatible scaffold as the carrier of neural stem cells in the reconstructive surgery of open traumatic brain injury (TBI) by parameters of neurological and cognitive status of the animals in the experiment.
Materials and Methods. Adult male C57BL/6 mice were injured with open-skull weight-drop method. 3D hydrogel scaffold based on modified chitosan in complex with hyaluronic acid was transplanted into the lesion cavity 1 week after TBI. Using a variety of behavioral and cognitive tests (modified neurological severity scores (mNSS), open field test as well as novel object recognition and passive avoidance tests) the short-and long-term neurological and memory functions sequelae induced by TBI were assessed. Magnetic resonance imaging was used to visualize the injury site.
Results. Significant functional recovery was observed on both the mNSS and open field tests in the scaffold transplantation group compared to the control TBI group. In addition, enhanced improvement of short and long-term memory functions was found 5 months post injury. Magnetic resonance imaging data revealed that the scaffold transplantation result in decreasing of the volume of injury area compared to control TBI group and preventing the disruption of the neural networks of the brain.
Conclusion. Taken together, our findings indicated that transplantation of 3D biodegradable scaffold into injury cavity contributed to the preservation of volume in the damaged region in the first months after TBI which in turn led to a better functional recovery in the remote period
Long-term neurological and behavioral results of biodegradable scaffold implantation in mice brain
The aim of the study was to assess the integral outcomes of implantation biocompatible scaffold as the carrier of neural stem cells in the reconstructive surgery of open traumatic brain injury (TBI) by parameters of neurological and cognitive status of the animals in the experiment.
Materials and Methods. Adult male C57BL/6 mice were injured with open-skull weight-drop method. 3D hydrogel scaffold based on modified chitosan in complex with hyaluronic acid was transplanted into the lesion cavity 1 week after TBI. Using a variety of behavioral and cognitive tests (modified neurological severity scores (mNSS), open field test as well as novel object recognition and passive avoidance tests) the short-and long-term neurological and memory functions sequelae induced by TBI were assessed. Magnetic resonance imaging was used to visualize the injury site.
Results. Significant functional recovery was observed on both the mNSS and open field tests in the scaffold transplantation group compared to the control TBI group. In addition, enhanced improvement of short and long-term memory functions was found 5 months post injury. Magnetic resonance imaging data revealed that the scaffold transplantation result in decreasing of the volume of injury area compared to control TBI group and preventing the disruption of the neural networks of the brain.
Conclusion. Taken together, our findings indicated that transplantation of 3D biodegradable scaffold into injury cavity contributed to the preservation of volume in the damaged region in the first months after TBI which in turn led to a better functional recovery in the remote period