Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

Modeling of direct conversion of the uranium fission product kinetic energy to laser radiation energy in an argon–xenon dusty plasma with uranium nanoparticles

The process of direct conversion of the uranium fission product kinetic energy to laser radiation (LR) energy in a moving argon–xenon laser-active gas medium containing uranium nanoparticles has been investigated. A model and a method have been developed to solve numerically equations for the model of direct uranium fission product kinetic energy conversion to laser radiation energy in such medium. Spatiotemporal evolutions of the uranium nanoparticle concentration distribution have been calculated for different gas flow velocities and uranium nanoparticle sizes. Kinetic processes in a moving argon–xenon laser-active gas medium containing uranium nanoparticles have been studied. It is the first time that amplifying properties of a laser-active spatially heterogeneous nuclear-excited moving argon–xenon medium, containing uranium nanoparticles and irradiated by neutrons, have been studied. As shown by the investigation results, the LR intensity amplification may be sevenfold and more in steady-state conditions. Such a high value makes it possible to state that this medium can be used not only in a nuclear-pumped laser but also in the mode of a single-pass nuclear-pumped laser amplifier

Intrinsic backgrounds from Rn and Kr in the XENON100 experiment

In this paper, we describe the XENON100 data analyses used to assess the target-intrinsic background sources radon (222Rn), thoron (220Rn) and krypton (85Kr). We detail the event selections of high-energy alpha particles and decay-specific delayed coincidences. We derive distributions of the individual radionuclides inside the detector and quantify their abundances during the main three science runs of the experiment over a period of ∼4 years, from January 2010 to January 2014. We compare our results to external measurements of radon emanation and krypton concentrations where we find good agreement. We report an observed reduction in concentrations of radon daughters that we attribute to the plating-out of charged ions on the negatively biased cathode

Search for Electronic Recoil Event Rate Modulation with 4 Years of XENON100 Data

We report on a search for electronic recoil event rate modulation signatures in the XENON100 data accumulated over a period of 4 yr, from January 2010 to January 2014. A profile likelihood method, which incorporates the stability of the XENON100 detector and the known electronic recoil background model, is used to quantify the significance of periodicity in the time distribution of events. There is a weak modulation signature at a period of 431-14+16 day in the low energy region of (2.0-5.8) keV in the single scatter event sample, with a global significance of 1.9σ; however, no other more significant modulation is observed. The significance of an annual modulation signature drops from 2.8σ, from a previous analysis of a subset of this data, to 1.8σ with all data combined. Single scatter events in the low energy region are thus used to exclude the DAMA/LIBRA annual modulation as being due to dark matter electron interactions via axial vector coupling at 5.7σ

First Dark Matter Search Results from the XENON1T Experiment

We report the first dark matter search results from XENON1T, a ∼2000−kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy and the first ton-scale detector of this kind. The blinded search used 34.2 live days of data acquired between November 2016 and January 2017. Inside the (1042±12)−kg fiducial mass and in the [5,40]  keVnr energy range of interest for weakly interacting massive particle (WIMP) dark matter searches, the electronic recoil background was (1.93±0.25)×10−4  events/(kg×day×keVee), the lowest ever achieved in such a dark matter detector. A profile likelihood analysis shows that the data are consistent with the background-only hypothesis. We derive the most stringent exclusion limits on the spin-independent WIMP-nucleon interaction cross section for WIMP masses above 10  GeV/c2, with a minimum of 7.7×10−47  cm2 for 35−GeV/c2 WIMPs at 90% C.L

Dark Matter Search Results from a One Ton-Year Exposure of XENON1T

We report on a search for weakly interacting massive particles (WIMPs) using 278.8 days of data collected with the XENON1T experiment at LNGS. XENON1T utilizes a liquid xenon time projection chamber with a fiducial mass of (1.30±0.01) ton, resulting in a 1.0 ton yr exposure. The energy region of interest, [1.4,10.6] keVee ([4.9,40.9] keVnr), exhibits an ultralow electron recoil background rate of [82-3+5(syst)±3(stat)] events/(ton yr keVee). No significant excess over background is found, and a profile likelihood analysis parametrized in spatial and energy dimensions excludes new parameter space for the WIMP-nucleon spin-independent elastic scatter cross section for WIMP masses above 6 GeV/c2, with a minimum of 4.1×10-47 cm2 at 30 GeV/c2 and a 90% confidence level

XENON1T dark matter data analysis: Signal and background models and statistical inference

The XENON1T experiment searches for dark matter particles through their scattering off xenon atoms in a 2 metric ton liquid xenon target. The detector is a dual-phase time projection chamber, which measures simultaneously the scintillation and ionization signals produced by interactions in target volume, to reconstruct energy and position, as well as the type of the interaction. The background rate in the central volume of XENON1T detector is the lowest achieved so far with a liquid xenon-based direct detection experiment. In this work we describe the response model of the detector, the background and signal models, and the statistical inference procedures used in the dark matter searches with a 1  metric ton×year exposure of XENON1T data, that leads to the best limit to date on WIMP-nucleon spin-independent elastic scatter cross section for WIMP masses above 6  GeV/c2

Search for bosonic super-WIMP interactions with the XENON100 experiment

We present results of searches for vector and pseudoscalar bosonic super-weakly interacting massive particles (WIMPs), which are dark matter candidates with masses at the keV-scale, with the XENON100 experiment. XENON100 is a dual-phase xenon time projection chamber operated at the Laboratori Nazionali del Gran Sasso. A profile likelihood analysis of data with an exposure of 224.6 live days ×34  kg showed no evidence for a signal above the expected background. We thus obtain new and stringent upper limits in the (8–125)  keV/c2 mass range, excluding couplings to electrons with coupling constants of gae>3×10−13 for pseudo-scalar and α′/α>2×10−28 for vector super-WIMPs, respectively. These limits are derived under the assumption that super-WIMPs constitute all of the dark matter in our galaxy

Online 222Rn removal by cryogenic distillation in the XENON100 experiment

We describe the purification of xenon from traces of the radioactive noble gas radon using a cryogenic distillation column. The distillation column was integrated into the gas purification loop of the XENON100 detector for online radon removal. This enabled us to significantly reduce the constant 222Rn background originating from radon emanation. After inserting an auxiliary 222Rn emanation source in the gas loop, we determined a radon reduction factor of R > 27 (95% C.L.) for the distillation column by monitoring the 222Rn activity concentration inside the XENON100 detector

Signal yields of keV electronic recoils and their discrimination from nuclear recoils in liquid xenon

We report on the response of liquid xenon to low energy electronic recoils below 15 keV from beta decays of tritium at drift fields of 92 V/cm, 154 V/cm and 366 V/cm using the XENON100 detector. A data-to-simulation fitting method based on Markov Chain Monte Carlo is used to extract the photon yields and recombination fluctuations from the experimental data. The photon yields measured at the two lower fields are in agreement with those from literature; additional measurements at a higher field of 366 V/cm are presented. The electronic and nuclear recoil discrimination as well as its dependence on the drift field and photon detection efficiency are investigated at these low energies. The results provide new measurements in the energy region of interest for dark matter searches using liquid xenon