ANGIOTENSIN CONVERTING ENZIME GENE I/D POLYMORPHISM AND PROMISSING OF RENOPROTECTIVE AND IMMUNOSUPRESSIVE THERAPY IN CHILDREN WITH NEPHROTIC SYNDROME

To investigate the role of i/d polymorphism gene angiotensin converting enzyme (ACE) in promissing of renoprotective and immunosupressive therapy in children with nephrotic syndrome syndrome (NS) we determined the genotypes of ACE in 76 children with ns including 22 children with chronic renal failure (CRF). the analysis of treatment effect with inhibitor ace in patients with steroid resistant ns (SRNS) demonstrated decreasing of renoprotective effect of these drugs in patients with DD genotype compared with ii and id genotypes (р = 0,033) by similar degree of the glomerular filtration rate (GFR), proteinuria and blood pressure decrease in these patients. Percentage of DD genotype in patients with ns refractory to therapy of cyclosporin a were height compared with patients, sensitive to this therapy.Key words: nephrotic syndrome, chronic renal failure, polymorphism of genes, renin-angiotensin system

RENIN ANGIOTENSIN SYSTEM GENE POLYMORPHISMS IN CHILDREN WITH NEPHROTIC SYNDROM

To investigate the role of the reninangiotensin system genes polymorphisms in develop and progression of nephrotic syndrom (NS) in children we determined the genotypes of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin ii receptor (ATII-R) of 1 type in 80 russian children with ns including and 15 children with chronic renal failure (CRF). Genotype frequencies did not differ between patients with ns and controls (n = 165). The distribution of ace, AGT and ATII-R 1 type genotypes was similar among ns sub groups, such as focal segmental glomerulosclerosis (FSGS) (n = 18), steroid-sensitive nephrotic syndrome (n = 32), nephrotic syndrome with hypertension and hemoturia (n = 22) and with control group. When ns subjects with CRF (n = 15) were compared with control, the prevalence of ace DD genotype was significantly higher (47% VS 21%; χ2 = 4,44; p < 0,05). Our results indicate that the DD genotype ace may be a factor of risk for the dеvеlopment of progressive renal impairment in the children with nephrotic syndrome. The analysis of treatment's effect with inhibitor of ace in groups patients with steroid resistant NS (SRNS) demonstrated decreasing of renoprotective effect of this drugs in patients with id and dd genotypes com? Pared with ii genotype: the degree of blood pressure, proteinuria and the rate of glomerular filtration decrease was significantly lower (55,46 ± 9,25 VS 92,74 ± 25; р < 0,05) in these patients.Key words: nephrotic syndrom, chronic renal failure, polymorphism of genes, renin-angiotensin system

ANGIOTENSIN CONVERTING ENZIME GENE I/D POLYMORPHISM AND PROMISSING OF RENOPROTECTIVE AND IMMUNOSUPRESSIVE THERAPY IN CHILDREN WITH NEPHROTIC SYNDROME

To investigate the role of i/d polymorphism gene angiotensin converting enzyme (ACE) in promissing of renoprotective and immunosupressive therapy in children with nephrotic syndrome syndrome (NS) we determined the genotypes of ACE in 76 children with ns including 22 children with chronic renal failure (CRF). the analysis of treatment effect with inhibitor ace in patients with steroid resistant ns (SRNS) demonstrated decreasing of renoprotective effect of these drugs in patients with DD genotype compared with ii and id genotypes (р = 0,033) by similar degree of the glomerular filtration rate (GFR), proteinuria and blood pressure decrease in these patients. Percentage of DD genotype in patients with ns refractory to therapy of cyclosporin a were height compared with patients, sensitive to this therapy.Key words: nephrotic syndrome, chronic renal failure, polymorphism of genes, renin-angiotensin system

RENIN ANGIOTENSIN SYSTEM GENE POLYMORPHISMS IN CHILDREN WITH NEPHROTIC SYNDROM

To investigate the role of the reninangiotensin system genes polymorphisms in develop and progression of nephrotic syndrom (NS) in children we determined the genotypes of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin ii receptor (ATII-R) of 1 type in 80 russian children with ns including and 15 children with chronic renal failure (CRF). Genotype frequencies did not differ between patients with ns and controls (n = 165). The distribution of ace, AGT and ATII-R 1 type genotypes was similar among ns sub groups, such as focal segmental glomerulosclerosis (FSGS) (n = 18), steroid-sensitive nephrotic syndrome (n = 32), nephrotic syndrome with hypertension and hemoturia (n = 22) and with control group. When ns subjects with CRF (n = 15) were compared with control, the prevalence of ace DD genotype was significantly higher (47% VS 21%; χ2 = 4,44; p < 0,05). Our results indicate that the DD genotype ace may be a factor of risk for the dеvеlopment of progressive renal impairment in the children with nephrotic syndrome. The analysis of treatment's effect with inhibitor of ace in groups patients with steroid resistant NS (SRNS) demonstrated decreasing of renoprotective effect of this drugs in patients with id and dd genotypes com? Pared with ii genotype: the degree of blood pressure, proteinuria and the rate of glomerular filtration decrease was significantly lower (55,46 ± 9,25 VS 92,74 ± 25; р < 0,05) in these patients.Key words: nephrotic syndrom, chronic renal failure, polymorphism of genes, renin-angiotensin system

A CLINICAL CASE: DIAGNOSTICS OF SHERESHEVSKY TERNER SYNDROME WITH MULTIPLE CONGENITAL ANOMALIES IN MAIN ARTERIES OF A 4 YEAR OLD CHILD, SUFFERING FROM ARTERIAL HYPERTENSION

The article provides a substantiation for the differential diagnostics of the symptomatic arterial hypertension of a 4 year old child, suffering from the arterial hypertension of the presumably renoparenchymal origin. In the course of the clinical examination, the researchers found out coarctation of aorta and hypoplasia of the right renal artery as a part of Shereshevsky-Terner syndrome.Key words: arterial hypertension, Shereshevsky-Terner syndrome, coarctation of aorta, renovascular hypertension