Possibility of Turbulence from a Post-Navier-Stokes Equation

We introduce corrections to the Navier-Stokes equation arising from the transitions between molecular states and the injection of external energy. In the simplest application of the proposed post Navier-Stokes equation, we find a multi-valued velocity field and the immediate possibility of velocity reversal, both features of turbulence

Wear Minimization for Cuckoo Hashing: How Not to Throw a Lot of Eggs into One Basket

We study wear-leveling techniques for cuckoo hashing, showing that it is possible to achieve a memory wear bound of $\log\log n+O(1)$ after the insertion of $n$ items into a table of size $Cn$ for a suitable constant $C$ using cuckoo hashing. Moreover, we study our cuckoo hashing method empirically, showing that it significantly improves on the memory wear performance for classic cuckoo hashing and linear probing in practice.Comment: 13 pages, 1 table, 7 figures; to appear at the 13th Symposium on Experimental Algorithms (SEA 2014

What can(not) be measured with ton-scale dark matter direct detection experiments

Direct searches for dark matter have prompted in recent years a great deal of excitement within the astroparticle physics community, but the compatibility between signal claims and null results of different experiments is far from being a settled issue. In this context, we study here the prospects for constraining the dark matter parameter space with the next generation of ton-scale detectors. Using realistic experimental capabilities for a wide range of targets (including fluorine, sodium, argon, germanium, iodine and xenon), the role of target complementarity is analysed in detail while including the impact of astrophysical uncertainties in a self-consistent manner. We show explicitly that a multi-target signal in future direct detection facilities can determine the sign of the ratio of scalar couplings $f_n/f_p$, but not its scale. This implies that the scalar-proton cross-section is left essentially unconstrained if the assumption $f_p\sim f_n$ is relaxed. Instead, we find that both the axial-proton cross-section and the ratio of axial couplings $a_n/a_p$ can be measured with fair accuracy if multi-ton instruments using sodium and iodine will eventually come online. Moreover, it turns out that future direct detection data can easily discriminate between elastic and inelastic scatterings. Finally, we argue that, with weak assumptions regarding the WIMP couplings and the astrophysics, only the dark matter mass and the inelastic parameter (i.e. mass splitting) may be inferred from the recoil spectra -- specifically, we anticipate an accuracy of tens of GeV (tens of keV) in the measurement of the dark matter mass (inelastic parameter).Comment: 31 pages, 7 figures, 7 table

Spin-independent elastic WIMP scattering and the DAMA annual modulation signal

We discuss the interpretation of the annual modulation signal seen in the DAMA experiment in terms of spin-independent elastic WIMP scattering. Taking into account channeling in the crystal as well as the spectral signature of the modulation signal we find that the low-mass WIMP region consistent with DAMA data is confined to WIMP masses close to $m_\chi \simeq 12$ GeV, in disagreement with the constraints from CDMS and XENON. We conclude that even if channeling is taken into account this interpretation of the DAMA modulation signal is disfavoured. There are no overlap regions in the parameter space at 90% CL and a consistency test gives the probability of $1.2\times 10^{-5}$. We study the robustness of this result with respect to variations of the WIMP velocity distribution in our galaxy, by changing various parameters of the distribution function, and by using the results of a realistic N-body dark matter simulation. We find that only by making rather extreme assumptions regarding halo properties can we obtain agreement between DAMA and CDMS/XENON.Comment: 21 pages, 12 figures, matches version accepted in JCA

Momentum-Resolved Tunneling into Fractional Quantum Hall Edges

Tunneling from a two-dimensional contact into quantum-Hall edges is considered theoretically for a case where the barrier is extended, uniform, and parallel to the edge. In contrast to previously realized tunneling geometries, details of the microscopic edge structure are exhibited directly in the voltage and magnetic-field dependence of the differential tunneling conductance. In particular, it is possible to measure the dispersion of the edge-magnetoplasmon mode, and the existence of additional, sometimes counterpropagating, edge-excitation branches could be detected.Comment: 4 pages, 3 figures, RevTex

Non-Newtonian effects in the peristaltic flow of a Maxwell fluid

We analyzed the effect of viscoelasticity on the dynamics of fluids in porous media by studying the flow of a Maxwell fluid in a circular tube, in which the flow is induced by a wave traveling on the tube wall. The present study investigates novelties brought about into the classic peristaltic mechanism by inclusion of non-Newtonian effects that are important, for example, for hydrocarbons. This problem has numerous applications in various branches of science, including stimulation of fluid flow in porous media under the effect of elastic waves. We have found that in the extreme non-Newtonian regime there is a possibility of a fluid flow in the direction {\it opposite} to the propagation of the wave traveling on the tube wall.Comment: to Appear in Phys. Rev. E., 01 September 2001 issu

Transport of Surface States in the Bulk Quantum Hall Effect

The two-dimensional surface of a coupled multilayer integer quantum Hall system consists of an anisotropic chiral metal. This unusual metal is characterized by ballistic motion transverse and diffusive motion parallel (\hat{z}) to the magnetic field. Employing a network model, we calculate numerically the phase coherent two-terminal z-axis conductance and its mesoscopic fluctuations. Quasi-1d localization effects are evident in the limit of many layers. We consider the role of inelastic de-phasing effects in modifying the transport of the chiral surface sheath, discussing their importance in the recent experiments of Druist et al.Comment: 9 pages LaTex, 9 postscript figures included using eps

Clinical and molecular characterization of HER2 amplified-pancreatic cancer

<p>Background: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies.</p> <p>Methods: HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC).</p> <p>Results: An amplified inversion event (1 MB) was identified at the HER2 locus in a patient with PDAC. Using standardized laboratory assays, we established diagnostic criteria for HER2 amplification in PDAC, and observed a prevalence of 2%. Clinically, HER2- amplified PDAC was characterized by a lack of liver metastases, and a preponderance of lung and brain metastases. Excluding breast and gastric cancer, the incidence of HER2-amplified cancers in the USA is >22,000 per annum.</p> <p>Conclusions: HER2 amplification occurs in 2% of PDAC, and has distinct features with implications for clinical practice. The molecular heterogeneity of PDAC implies that even an incidence of 2% represents an attractive target for anti-HER2 therapies, as options for PDAC are limited. Recruiting patients based on HER2 amplification, rather than organ of origin, could make trials of anti-HER2 therapies feasible in less common cancer types.</p&gt