Regional localization by in situ hybridization of a human chromosome 9 marker tightly linked to the Friederich's ataxia locus.

In order to determine the regional localization of the Friedreich's ataxia (FA) gene on chromosome 9, the DNA probe DR47 (D9S5), which detects a restriction fragment length polymorphism (RFLP) in tight linkage with the disease, was hybridized in situ to metaphase chromosomes. Our results enable the D9S5 locus to be assigned to the 9q12-q13 region, thus indicating that this is also the localization of the FA gene

Moegliche Wirkungen auf die Umwelt bei gentechnischen Arbeiten mit Phytopathogenen

Different German and foreign lists of organisms developed for safety assessment of genetic engineering were investigated. The objective of the study was to investigate whether the existing lists of organisms are suitable for safety assessment of genetic engineering using phytopathogenic bacteria, fungi or viruses with respect to possible environmental affects. In addition to the analysis of the existing organism lists the different diseases of crops and wild plants relevant for Central Europe were compiled. These compilations were compared with the different organism lists for safety assessment of genetic engineering. Specific traits of phytopathogenic microorganisms were evaluated with respect to their potential risks. Presumptive applications of genetic engineering with phytopathogenic microorganisms were discussed. (orig.)Available from TIB Hannover: RN 8908(96-065) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEUmweltbundesamt, Berlin (Germany); Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)DEGerman

Stand der Sicherheitsforschung zur Freisetzung transgener Organismen. Auswertung internationaler und nationaler Erkenntnisse

The study contains a compilation of the results of German and international research projects concerning safety aspects related to the deliberate release of genetically engineered organisms since 1992. The results have been compiled and compared as far as possible. This study is intended to help people working on criteria for the evaluation of safety aspects concerning deliberate release of genetically modified organisms. The most important aspects have been elaborated separately for transgenic microorganisms, plants and animals. Aspects are described with demand for research. (orig.)Available from TIB Hannover: RN 8422(1996,43) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)DEGerman

DNA-Sonden zur Erfassung erblicher Defekte beim Menschen Schlussbericht

TIB Hannover: FR 0998+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman