Testing microscopically derived descriptions of nuclear collectivity : Coulomb excitation of 22Mg

Many-body nuclear theory utilizing microscopic or chiral potentials has developed to the point that collectivity might be studied within a microscopic or ab initio framework without the use of effective charges; for example with the proper evolution of the E2 operator, or alternatively, through the use of an appropriate and manageable subset of particle–hole excitations. We present a precise determination of E2 strength in 22Mg and its mirror 22Ne by Coulomb excitation, allowing for rigorous comparisons with theory. No-core symplectic shell-model calculations were performed and agree with the new B(E2) values while in-medium similarity-renormalization-group calculations consistently underpredict the absolute strength, with the missing strength found to have both isoscalar and isovector components. The discrepancy between two microscopic models demonstrates the sensitivity of E2 strength to the choice of many-body approximation employed

Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score

Background: Recent findings strongly support hematopoietic stem cell transplantation (HSCT) in patients with severe presentation of LPS-responsive beige-like anchor protein (LRBA) deficiency, but long-term follow-up and survival data beyond previous patient reports or meta-reviews are scarce for those patients who do not receive a transplant.Objective: This international retrospective study was conducted to elucidate the longitudinal clinical course of patients with LRBA deficiency who do and do not receive a transplant.Method: We assessed disease burden and treatment responses with a specially developed immune deficiency and dysregulation activity score, reflecting the sum and severity of organ involvement and infections, days of hospitalization, supportive care requirements, and performance indices.Results: Of 76 patients with LRBA deficiency from 29 centers (median follow-up, 10 years; range, 1-52), 24 underwent HSCT from 2005 to 2019. The overall survival rate after HSCT (median follow-up, 20 months) was 70.8% (17 of 24 patients); all deaths were due to nonspecific, early, transplant-related mortality. Currently, 82.7% of patients who did not receive a transplant (43 of 52; age range, 3-69 years) are alive. Of 17 HSCT survivors, 7 are in complete remission and 5 are in good partial remission without treatment (together, 12 of 17 [70.6%]). In contrast, only 5 of 43 patients who did not receive a transplant (11.6%) are without immunosuppression. Immune deficiency and dysregulation activity scores were significantly lower in patients who survived HSCT than in those receiving conventional treatment (P = .005) or in patients who received abatacept or sirolimus as compared with other therapies, and in patients with residual LRBA expression. Higher disease burden, longer duration before HSCT, and lung involvement were associated with poor outcome.Conclusion: The lifelong disease activity, implying a need for immunosuppression and risk of malignancy, must be weighed against the risks of HSCT.Transplantation and immunomodulatio

ANC method: Experimental approach and recent results

The Asymptotic Normalization Coefficient (ANC) method, has proven to be useful in retrieving the direct part of the radiative capture cross section for a number of reactions of astrophysical interest. In this work, some of the latest results obtained by the AsFin2 group of the LSN-INFN (Catania) and the OJR of the NPI (Řež) will be briefly discussed

Full orbital solution for the binary system in the northern Galactic disc microlensing event Gaia16aye

© ESO 2020. Gaia16aye was a binary microlensing event discovered in the direction towards the northern Galactic disc and was one of the first microlensing events detected and alerted to by the Gaia space mission. Its light curve exhibited five distinct brightening episodes, reaching up to I? =? 12 mag, and it was covered in great detail with almost 25 000 data points gathered by a network of telescopes. We present the photometric and spectroscopic follow-up covering 500 days of the event evolution. We employed a full Keplerian binary orbit microlensing model combined with the motion of Earth and Gaia around the Sun to reproduce the complex light curve. The photometric data allowed us to solve the microlensing event entirely and to derive the complete and unique set of orbital parameters of the binary lensing system. We also report on the detection of the first-ever microlensing space-parallax between the Earth and Gaia located at L2. The properties of the binary system were derived from microlensing parameters, and we found that the system is composed of two main-sequence stars with masses 0.57 ± 0.05 M? and 0.36 ± 0.03 M? at 780 pc, with an orbital period of 2.88 years and an eccentricity of 0.30. We also predict the astrometric microlensing signal for this binary lens as it will be seen by Gaia as well as the radial velocity curve for the binary system. Events such as Gaia16aye indicate the potential for the microlensing method of probing the mass function of dark objects, including black holes, in directions other than that of the Galactic bulge. This case also emphasises the importance of long-term time-domain coordinated observations that can be made with a network of heterogeneous telescopes