СТАБИЛЬНОСТЬ КАРПОЛОГИЧЕСКИХ ПРИЗНАКОВ ЛЕКАРСТВЕННЫХ РАСТЕНИЙ ТРИБЫ CARDUEAE (COMPOSITAE) ПРИ КОЛЛЕКЦИОННОМ ХРАНЕНИИ

The anatomy of cypselas of 4 species from tribe Cardueae (Compositae) was studied. The specimens were storaged over 50 years in collection in MSU. The physic-optical traits of cell structures were investigated and basic microchemical tastes was conducted. The results were compared with ones of fresh materials and literature data.Изучена анатомия плодов представителей 4 родов трибы Cardueae, взятых из коллекционного материала, хранившегося более 50 лет, исследованы физико-оптические свойства клеточных структур, проведены микрохимические реакции на основные классы веществ. Проведено сравнение со свежим материалом и с литературными данными. Результаты показали хорошую сохранность анатомических диагностических признаков в условиях воздушно-сухого хранения. Признаки внешней микроморфологии искажаются или утрачиваются

Идентификация перспективного лекарственного сырья "Пустырника плоды"

The fruits of Leonurus cardiaca L. may be a promising fatty-oil raw material. A necessary part of the regulatory document for any type of raw material is the section «Identification». The morphological features of the Leonurus cardiaca fruits, as a seed, are set forth in the literature, but the external characteristics are not sufficient for describing the raw material. We supplemented the existing parameters. The anatomical diagnostic signs of Leonurus cardiaca fruits were studied and microchemical reactions were conducted to the presence of various groups of biologically active substances. A study conducted in transmitted polarized light with crossed polarizer axes and an analyzer was spend to investigate the optical properties of cell walls and intracellular structures. Qualitative reactions with extracts from whole fruits were also carried out. Identification criteria (description of external signs, anatomical diagnostic features, definition of the main groups of biologically active substances) for raw materials «Leonuri fructus» were developed.Проведена идентификация (описание внешних признаков, анатомических диагностических признаков, определение основных групп биологически активных веществ) сырья «Leonuri fructus» - «Пустырника плоды». Разработаны критерии идентификации плодов пустырника для создания нормативной документации (раздел «Подлинность») перспективного вида на лекарственное растительное сырье «Пустырника сердечного плоды»

Сardiac microhemocirculation in experimental myocardium necrosis

Babaieva A.G., Chizh N.A., Galchenko S.Ye., Sandomirsky B.P. Сardiac microhemocirculation in experimental myocardium necrosis. Cardiovascular Research. 2012. 93, Suppl. 1. P. 52.Cardiac microhemocirculation in experimental myocardium necrosi

Study of Nepetae catariae herba fruits as promising medicinal plant raw material

Nepetae catariae herba is used in the Russian Federation as spice. The chemical compounds of herb have been studied. This plant has been introduced into the culture. There are its domestic varieties. The fruits of the plant accumulate up to 25% of fatty oil and contain specific laballenic acid, which has a wide range of antimicrobial and fungicidal actions. The yield of fruit crops is 5-6 c/ha. The aim is to study some criteria for the standardization of the quality of Nepetae catariae herb as a new medicinal plant raw material. Materials and methods. The studied fruits are from the biological collection of Federal State Budgetary Institution of All - Russia Research Institute of Medicinal and Aromatic Plants. Binocular magnifier brand MBS-10 and Axioplan 2 imaging microscope by Carl Zeiss were used. The sample preparation was carried out according to the State Pharmacopoeia of the Russian Federation (XIV edition). Anatomical diagnostic features were studied in powder and cross section with staining reagents for the presence of some biologically active substances. Qualitative reactions were carried out with water and alcohol-water extracts from the fruits. The content of the lipid complex according to pharmacopoeia monograph 2.5.0035.15 has been determined. Results. A description of the external and diagnostic anatomical features is given. The main groups of biologically active substances and the content of the lipid complex in a possible new material - the fruits of Nepeta cataria - have been identified. Conclusion. The description of the external features of the fruit has been specified. For the first time, crushed fruits have been characterized. It has been established that the morphology of endocarp cells and seed embryo cells are best preserved in a mellow fruit. Physico-optical properties of cellular structures and the ability for basic microchemical reactions are preserved in all zones of pericarp and seeds. Qualitative reactions showed the presence of the following components in the fruits: saponins, flavonoids and a lipid complex. A dispersion composition has been studied. The yield of the lipid complex and its appearance have been determined. Fruits can be used as promising fat-oil raw materials. The results of the study can be used in drafting Pharmacovigilance Reference Document considering a promising type of medicinal plant raw material on the basis of Nepetae catariae herba fruits. © 2019 Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute. All rights reserved

Моделирование некроза миокарда в эксперименте и создание сосудистых ксенопротезов для регенеративной медицины

Chizh NA, Byzov DV, Shkand TV, Babaeva AG, Trofimova AV, Mikhaylova IP, Sleta IV, Sandomirsky BP. Experimental Model of Myocardial Necrosis and Creation of Vascular Xenoprostheses for Regenerative Medicine. Probl Cryobiol Cryomed. 2013; 23(4): 368-72.Experimental Model of Myocardial Necrosis and Creation of Vascular Xenoprostheses for Regenerative Medicin