Effect of glucose on K+ handling by pancreatic islets

Data are presented which confirm and extend conclusions derived from previous experiments carried out with 86Rb+. They suggest that glucose, by reducing the permeability of the plasma membrane to effluent K+, increases the concentration of K+ in the islet cells and under steady-state conditions, reduces proportionally the fractional turnover rate of the cellular K+ pool. Glucose, however, does not increase the inflow-outflow rate of K+ into the islet cells. The mechanism by which glucose affects the permeability of the plasma membrane to effluent K+ remains to be elucidated.SCOPUS: ar.jinfo:eu-repo/semantics/publishe