An Autonomous Lunar Geophysical Experiment Package (ALGEP) for future space missions

Geophysical observations will provide key information about the inner structure of the planets and satellites and understanding the internal structure is a strong constraint on the bulk composition and thermal evolution of these bodies. Thus, geophysical observations are a key to uncovering the origin and evolution of the Moon. In this article, we propose the development of an autonomous lunar geophysical experiment package, composed of a suite of instruments and a central station with standardized interface, which can be installed on various future lunar missions. By fixing the interface between instruments and the central station, it would be possible to easily configure an appropriate experiment package for different missions. We describe here a series of geophysical instruments that may be included as part of the geophysical package: a seismometer, a magnetometer, a heat flow probe, and a laser reflector. These instruments will provide mechanical, thermal, and geodetic parameters of the Moon that are strongly related to the internal structure. We discuss the functionality required for future geophysical observations of the Moon, including the development of the central station that will be used commonly by different payloads

PLANET TOPERS: Planets, Tracing the Transfer, Origin, Preservation, and Evolution of their ReservoirS

info:eu-repo/semantics/publishe

Standardization of Flow Cytometric Immunophenotyping for Hematological Malignancies: The FranceFlow Group Experience.

Flow cytometry is broadly used for the identification, characterization, and monitoring of hematological malignancies. However, the use of clinical flow cytometry is restricted by its lack of reproducibility across multiple centers. Since 2006, the EuroFlow consortium has been developing a standardized procedure detailing the whole process from instrument settings to data analysis. The FranceFlow group was created in 2010 with the intention to educate participating centers in France about the standardized instrument setting protocol (SOP) developed by the EuroFlow consortium and to organise several rounds of quality controls (QCs) in order to evaluate the feasibility of its application and its results. Here, we report the 5 year experience of the FranceFlow group and the results of the seven QCs of 23 instruments, involving up to 19 centers, in France and in Belgium. The FranceFlow group demonstrates that both the distribution and applicability of the SOP have been successful. Intercenter reproducibility was evaluated using both normal and pathological blood samples. Coefficients of variation (CVs) across the centers were <7% for the percentages of cell subsets and <30% for the median fluorescence intensities (MFIs) of the markers tested. Intracenter reproducibility provided similar results with CVs of <3% for the percentages of the majority of cell subsets, and CVs of <20% for the MFI values for the majority of markers. Altogether, the FranceFlow group show that the 19 participating labs might be considered as one unique laboratory with 23 identical flow cytometers able to reproduce identical results. Therefore, SOP significantly improves reproducibility of clinical flow in hematology and opens new avenues by providing a robust companion diagnostic tool for clinical trials in hematology. © 2019 International Society for Advancement of Cytometry