A simple landscape design framework for biodiversity conservation

Local government planning agencies play an important role in conserving biodiversity in human-altered landscapes. Such agencies frequently have a limited knowledge of wildlife biology and few resources to carry out research, and therefore require simple, practical guidelines for biodiversity conservation. We propose a landscape design framework for biodiversity conservation that is sequential, prescriptive, and supported by current landscape ecological science. Unlike existing guidelines, our framework can be implemented in any given landscape using only land cover data and it explicitly considers constraints on land use planning. The steps of our framework, in the order in which they should be implemented are: (1) select land cover data and decide which land cover classes constitute unaltered or altered land covers; (2) list the constraints on land use planning (e.g., economic, social) that exist for the landscape (3) maximize the total amount and diversity of unaltered land cover, especially near water; (4) minimize human disturbance within altered land cover, especially near water; and (5) aggregate altered land covers associated with high-intensity land uses, especially away from water. We illustrate the utility of our approach by applying it to a hypothetical landscape and comparing the outcome to those from the application of traditional ecological guidelines to inform land use planning

Hypoxic adaptation during development: relation to pattern of neurological presentation and cognitive disability

Children with acute hypoxic-ischaemic events (e.g. stroke) and chronic neurological conditions associated with hypoxia frequently present to paediatric neurologists. Failure to adapt to hypoxia may be a common pathophysiological pathway linking a number of other conditions of childhood with cognitive deficit. There is evidence that congenital cardiac disease, asthma and sleep disordered breathing, for example, are associated with cognitive deficit, but little is known about the mechanism and whether there is any structural change. This review describes what is known about how the brain reacts and adapts to hypoxia, focusing on epilepsy and sickle cell disease (SCD). We prospectively recorded overnight oxyhaemoglobin saturation (SpO 2) in 18 children with intractable epilepsy, six of whom were currently or recently in minor status (MS). Children with MS were more likely to have an abnormal sleep study defined as either mean baseline SpO2 &lt;94 or &gt;4 dips of &gt;4 in SpO2/hour (p = .04). In our series of prospectively followed patients with SCD who subsequently developed acute neurological symptoms and signs, mean overnight SpO2 was lower in those with cerebrovascular disease on magnetic resonance angiography (Mann-Whitney, p = .01). Acute, intermittent and chronic hypoxia may have detrimental effects on the brain, the clinical manifestations perhaps depending on rapidity of presentation and prior exposure.</p