Prevention of cancer risk of workers of glass fibers manufacture

In the process of producing of continuous glass fiber workers are exposed to complex impact of carcinogenic chemicals released into the air of the working area (including formaldehyde, epichlorohydrin, ethane acids, aerosol of mineral oil). The penetrating effect of harmful substances through the skin is enhanced by the fine glass dust, which has a traumatic and irritating effect. Aggravating factors of the impact of lubricants on the body of the operators is the increased temperature and the excess of heat radiation. A risk factor is also the unfavorable climate of the workplace. Among the professional patients (71 person of 170 examined employees) most of persons aged 50–59 years. The average age of the patients at the time of detection of hyperkeratosis was 51,9 ± 0,9 years, skin cancer – 57,3 ± 1,7 years. Professional skin neoplasms were diagnosed mainly in workers who have been working for more than 10 years (average period of 12.6 ± 2.4 years). The period of transformation of limited hyperkeratosis to the skin cancer was on average 5–8 years. It was found that the molecular-genetic factors predisposing to the development of professional skin lesions are polymorphic variants of the gene suppressor of tumor growth TP53 (Ex4 + 119G>C, IVS3 16 bp Del/Ins and IVS6+62A>G). It has been shown that the development of preventive measures aimed at reducing the risk of occupational diseases is relevant and should include the interaction of administration, engineering and technical staff of the enterprise, labor protection service, Rospotrebnadzor specialists, doctors specialized in occupational diseases and the workers themselves. The complex of measures of primary and secondary prevention of health problems is suggested. The necessity of including the continuous glass fiber production to the list of carcinogen production processes, presented in national normative documents

Complex evaluation of health status and life quality of employees occupied in mining and processing of hydrocarbon raw materials

A complex social-hygienic investigation for the assessment of health-related life quality and living standards among 1200 male workers occupied in mining and primary processing of hydrocarbon raw materials has been performed. The study included the method of the anonymous survey for the employee with using a questionnaire developed by WHO experts for the realization of Health, environment and social capital management in enterprises (HESME). The health risk factors’ prevalence associated with alcohol, smoking, low physical activity, poor nutrition, stress in the workplace has been established. The feeling of stress and nervousness is generated by the fear of dismissal (18 % of employees), conflicts with administration (4%) and by financial problems. About 47% of persons are anxious about social and economic instability. Not more than 4% of employees consider that the health deterioration is directly related to harmful working conditions. The survey has revealed an inflated self-esteem regarding the health. Thus 59.00 % of employee considers their health status to be excellent or normal, while an objective assessment revealed only 29.7 % of healthy employee. Due to the employee’s opinion, the saving of health is conditioned by healthy lifestyle, but the practice of self-preservation behavior is poorly spread. Not more than 37 % of respondents follow the doctors’ recommendations. Among the positive process there are changes in dietary habits in everyday life, namely 60 % of the respondents have chosen the balanced diet. The obtained data regarding the quality and way of life of the employee, occupied in mining and processing of hydrocarbon raw materials, should be taken into consideration when developing complex social development programs on an enterprise

Risk of dust bronchopulmonary pathology development in workers employed in various economic brunches under impacts exerted by occupational risk factors: clinical and hygienic aspects

We performed complex clinical and hygienic research on 234 workers suffering from occupational bronchitis; they were employed in petrochemical industry, mining, civil engineering, as well as in construction. Group of workers with occu-pational diseases comprised hose suffering from dust bronchitis and toxic-dust bronchitis. Workers employed in the exam-ined branches had to work under exposure to production aerosols with complex structure and they working conditions had 3.2–3.4 hazard degree. We showed that occupational factors exerted negative influence on workers' health as they caused occupational bronchitis development, grave complications, and frequent associated diseases evolvement. The paper dwells on the results of our research on lipid peroxidation products content in workers exposed to production aerosols. We detected increased activity of free radical oxidation caused by impacts exerted by production aerosols; here we revealed that growth in lipid peroxidation products depended on duration of work under hazardous conditions. We set a goal to detect correlation between polymorph gene types of xenobiotics transformation enzymes and occupational bronchitis evolvement via poly-merase chain reaction technique; to achieve this, we analyzed polymorphic locuses in a group of sick workers (131 people) and healthy ones (156 people). We determined genetic markers which had protective significance in terms of occupational bronchitis evolvement risk. The research results prove that occupational bronchitis nature and peculiarities of its clinic pic-ture are determined both by occupational impacts and individual features of a worker' s body

Occupational risks for health of the workers of the chemical complex

The article summarizes the materials of long-term studies to assess the working conditions, state of health in workers of the chemical industry - mainly manufacturers of ethylbenzene, styrene, olefin oxides, rocket fuel. It was found that the most adverse working conditions are typical for the production of heptyl, rubber and fiberglass. The causal relationships of working conditions in the form of an increased incidence of early (pre-clinical) stages of occupational diseases, as well as major chronic non-communicable diseases, are identified. It is shown that depending on the tropism, mechanism of action and intensity of the chemical factor a clear staging of the development of pathological changes in the body is recorded. A very high degree of professional conditionality of early toxic hepatitis stages (biliary dyskinesia) in a heptyl production operator was determined, as well as initial manifestations of autonomic-sensory polyneuropathy in hands of the workers splicing rubber products, specific changes of the hand skin in glass production operators. Production-related diseases with a high degree of conditionality in certain categories of workers include diseases of the musculoskeletal system; hypertension had an average degree of conditionality. During in-depth medical examination of 2411 workers it was found that the largest number of healthy individuals were identified in the bulk manufacture of ethylbenzene – styrene (54.7 %), and olefin oxide (35,0 %) of the number of inspected workers, the least number (12 %) – in the manufacture of rubber products. The remaining workers demonstrated the pathology of various organs and systems. Based on the results of risk assessment and professional damage to the workers’ health the chemical productions are ranked according to their degree of danger, a system of preventive measures and risk management principles has been developed. The programme implementation resulted in the positive effect of more than 2 billion rubles

Production and genetic risk factors for cardiovascular diseases among petrochemical industry workers

Aim. To study the production and genetic factors affecting the cardiovascular system (CVS) in the petrochemical industry workers. Subjects and methods. There was carried out an assessment of the working conditions and the state of health of 860 workers of petrochemical plants males, including 548 apparatchiks (main group) and 312 fitters of instrumentation and automation (comparison group). The main risk factors with subsequent assessment of cardiovascular risk (SSR) on the scale SCORE (Sistematic COronary Risk Evaluation) were studied. The analysis of the frequency distribution of deletion polymorphisms of GSTM1 and GSTT1 glutathione among the workers of the basic trades involving patients with cardiovascular disease (CVD) and practically healthy workers. Results. The development and progression of CVD in petrochemical production workers affects a complex working environment hazards and the labor process, corresponding, according to R2.2.2006-05, classes, working conditions 3.1-3.3 Labor intensity. The most common form of cardiovascular nosology was hypertonic disease (HD), identified in 46,9% of apparatchiks and 29,2% of fitters of instrumentation and automation. Determination of the relative risk etiological share of the working environment factors in the development of HD showed high degree of professional conditioning of the disease in a group of apparatchiks (RR=1,58, and EF=36,7%). Molecular genetic factor predisposing to the development of CVD, is the deletion of the GSTM1 gene. This genetic marker could be used as a predictor of individual risk criterion CVD. Conclusion. A comprehensive assessment of working conditions of workers of petrochemical plants showed that the priority factors of occupational risk for apparatchiks are air pollution of the working area with harmful substances (class 3.1-3.2), noise (class 3.1) and labor intensity (class 3.1). It has been established that in the formation of cardiovascular diseases under the influence of production factors, genetic factors can participate

Assessing risks of functional disorders of hepatobiliary system in workers employed at butyl rubber production allowing for analysis of the ogg1 gene polymorphic variant rs1052133

Contemporary petrochemical productions maintain strict control over contents of adverse chemicals in workplace air. Despite that, the chemical factor remains one of the major harmful occupational factors and can produce adverse effects on workers’ health by increasing, among other things, risks of general somatic diseases. Given that, prevention of chronic non-communicable diseases in workers employed at chemical productions remains a vital challenge for occupational medicine. A way to tackle it is to timely detect risk groups relying on, among other things, analysis of workers’ genetic peculiarities. This article presents a study with 140 volunteers participating in it; they had basic occupations required at contemporary butyl rubber production. It was conducted within a periodical medical examination that involved using up-to-date hygienic, clinical-laboratory and genetic methods. The study included hygienic assessment of the chemical factor at the analyzed production, examination of hematologic and biochemical blood indicators, identification of workers’ genetic status as per the rs1052133 polymorphic variant of the OGG1 gene and the severity of DNA breaks. The study revealed adverse effects produced by the chemical factors on health of workers with basic occupations based on deviations in biochemical blood indicators obtained by tests that included indicator enzyme identification, and DNA damage. Following the study results, a risk group was created as per the state of the hepatobiliary system. To preserve workers’ health, it is necessary to implement certain preventive measures that include providing safe working conditions as regards the chemical factor, timely detection of risk groups and rehabilitation activities

Estimation of risk to health of the population of mining territories of bashkortostan connected with quality of drinking water supply

The ecology-hygienic problems connected with quality of drinking water supply of the settlements, located on territories with the developed mining industry are considered in this article. Poor quality of drinking water represents risk to health of the population and, according to the WHO’s data, it provides the risk of occurrence of those or other diseases on 7 %. The mining enterprises are significant sources of pollution of objects of environment, including underground water horizons as their activity is interfaced to formation of great volumes of the waste containing zinc, copper, arsenic, lead, manganese, cadmium, mercury, chrome, etc. Morbidity of the population living in regions with the developed mining industry, is raised on the number of classes of illnesses and separate nosologies (illnesses of cardiocirculatory system, urinogenital system, organs of digestion, etc.). The purpose of this research was carrying out of an estimation of quality of sources of drinking water supply and definition of an existing risk level to health of the population of mining territories with the subsequent development of hygienic recommendations and actions on optimization of conditions of water use. Hygienic researches are lead in settlements of mining territories of Republic Bashkortostan. Thirty settlements with the population of more than 200 thousand people were included into this research. The special attention was given to non-centralized sources of water supply (chinks, wells, springs) of mining territories used by inhabitants for the domestic and drinking purposes. It is established, that the qualitative structure of drinking water of investigated territories is characterized by the raised rigidity, the high concentration of iron, nitrates, chrome, cadmium. In separate territories of investigated region the unacceptable level of total olfactory risk, connected with the high concentration of iron and the raised rigidity of drinking water was revealed. Parameters of not cancerogenic risk, define high probability of development of a pathology from cardiovascular system, system of blood. The calculated levels of cancerogenic risks are estimated as unacceptable, testifying about existence of potential health hazard of the population

Palaeozoic evolution of the North Tianshan based on palaeomagnetic data – transition from Gondwana towards Pangaea

© 2017 Informa UK Limited, trading as Taylor & Francis GroupWe present new palaeomagnetic data for Cambrian and Ordovician volcanic and sedimentary rocks from the Kyrgyz North Tianshan (NTS) and review available data from the southwestern Central Asian Orogenic Belt (CAOB) to elucidate the tectonic history and evolution of this region during the early Palaeozoic. We observed a coherent evolution of the NTS and the Kazakhstan continent (or Kazakhstania) with a constant northwards movement between the Cambrian and Devonian at ~5 cm/a. After the northwards movement ceased in the Devonian, the accreted terrane assemblage of Kazakhstania occupied a stable latitudinal position at ~30°N until the final amalgamation of Eurasia occurred in the late Carboniferous to early Permian. Amalgamation of the Tarim and Turan blocks caused a counterclockwise bending within the southwestern segment of the CAOB, which occurred in an inconsistent way by a brittle-like response of the upper crust with a large variety of rotational movement. We suggest an evolution of the Kyrgyz CAOB terranes by steady migration away from Gondwana and subsequent capture in a zone of global downwelling at ~30°N, where accretion and subsequent amalgamation of Eurasia occurred with the CAOB terranes in its centre