20 research outputs found

    A copolymer near a selective interface: variational characterization of the free energy

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    Analysis and Stochastic

    The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

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    INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

    Parameter Evaluation for a Statistical Mechanical Model for Binary Choice with Social Interaction

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    In this paper we use a statistical mechanical model as a paradigm for educational choices when the reference population is partitioned according to the socioeconomic attributes of gender and residence. We study how educational attainment is influenced by socioeconomic attributes of gender and residence for five selected developing countries. The model has a social and a private incentive part with coefficients measuring the influence individuals have on each other and the external influence on individuals, respectively. The methods of partial least squares and the ordinary least squares are, respectively, used to estimate the parameters of the interacting and the noninteracting models. This work differs from the previous work that motivated this work in the following sense: (a) the reference population is divided into subgroups with unequal subgroup sizes, (b) the proportion of individuals in each of the subgroups may depend on the population size N, and (c) the method of partial least squares is used for estimating the parameters of the model with social interaction as opposed to the least squares method used in the earlier work

    A Statistical Mechanics Approach to the Study of Energy Use Behaviour

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    This paper proposes a statistical mechanical model for the energy conservation behaviour of energy users. The model was inspired by the multipopulation Curie-Weiss model and the discrete choice with social interaction model. We demonstrate that the model integrates the sociopsychological, the economic, and the energy technologist viewpoints to energy management, allowing us to subject these perspectives to an empirical study

    Gibbs–non-Gibbs properties for n-vector lattice and mean-field models

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    Abstract We review some recent developments in the study of Gibbs and non-Gibbs properties of transformed n-vector lattice and mean-field models under various transformations. Also, some new results for the loss and recovery of the Gibbs property of planar rotor models during stochastic time evolution are presented. Keywords: Gibbs measures; non-Gibbsian measures; n-vector lattice models; n-vector mean-field models; transformed model; Dobrushin uniqueness; cluster expansion; spin-flop transitions
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