Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa

Past reviews on Cimicifuga racemosa (CR) without differentiation between extracts, quality, and indication altogether led to inconsistent data. Therefore, for the first time, we meet the requirements of the system's logic of evidence-based phytotherapy by taking into consideration extracts, pharmaceutical quality (reflected in a regulatory status as medicinal product), and indication. A literature search for clinical studies examining CR's efficacy and safety for menopausal complaints was conducted. The results were sorted by type of extract, regulatory status, and indication. Accordingly, Oxford Levels of Evidence (LOE) and Grades of Recommendation (GR) were determined. CR extracts demonstrated a good to very good safety in general, on estrogen-sensitive organs and the liver. However, only registered CR medicinal products were able to prove their efficacy. Best evidence was provided by the isopropanolic CR extract (iCR): the multitude of studies including more than 11,000 patients demonstrated consistent confirmatory evidence of LOE 1b (LOE 1a for safety) leading to GR A. The studies on the ethanolic extract BNO 1055 including more than 500 patients showed exploratory evidence of LOE 2b resulting in GR B. A positive benefit-risk profile is stated and limited to Cimicifuga racemosa products holding a marketing authorisation for treating climacteric complaints

The light curve of the companion to PSR B1957+20

We present a new analysis of the light curve for the secondary star in the eclipsing binary millisecond pulsar system PSR B1957+20. Combining previous data and new data points at minimum from the Hubble Space Telescope, we have 100% coverage in the R-band. We also have a number of new K_s-band data points, which we use to constrain the infrared magnitude of the system. We model this with the Eclipsing Light Curve code (ELC). From the modelling with the ELC code we obtain colour information about the secondary at minimum light in BVRI and K. For our best fit model we are able to constrain the system inclination to 65 +/- 2 degrees for pulsar masses ranging from 1.3 -- 1.9 M_sun. The pulsar mass is unconstrained. We also find that the secondary star is not filling its Roche lobe. The temperature of the un-irradiated side of the companion is in agreement with previous estimates and we find that the observed temperature gradient across the secondary star is physically sustainable.Comment: 6 pages, 4 figures & 3tables. Accepted for publication in MNRA

Collaboration and teamwork: immersion and presence in an online learning environment

In the world of OTIS, an online Internet School for occupational therapists, students from four European countries were encouraged to work collaboratively through problem-based learning by interacting with each other in a virtual semi-immersive environment. This paper describes, often in their own words, the experience of European occupational therapy students working together across national and cultural boundaries. Collaboration and teamwork were facilitated exclusively through an online environment, since the students never met each other physically during the OTIS pilot course. The aim of the paper is to explore the observations that here was little interaction between students from different tutorial groups and virtual teamwork developed in each of the cross-cultural tutorial groups. Synchronous data from the students was captured during tutorial sessions and peer-booked meetings and analysed using the qualitative constructs of ‘immersion’, ‘presence’ and ‘reflection in learning’. The findings indicate that ‘immersion’ was experienced only to a certain extent. However, both ‘presence’ and shared presence were found by the students, within their tutorial groups, to help collaboration and teamwork. Other evidence suggests that communities of interest were established. Further study is proposed to support group work in an online learning environment. It is possible to conclude that collaborative systems can be designed, which encourage students to build trust and teamwork in a cross cultural online learning environment.</p

21st century housing careers and Australia's future: literature review

Andrew Beer, Debbie Faulkner and Michelle Gabrie

Bedload transport controls bedrock erosion under sediment-starved conditions

Fluvial bedrock incision constrains the pace of mountainous landscape evolution. Bedrock erosion processes have been described with incision models that are widely applied in river-reach and catchment-scale studies. However, so far no linked field data set at the process scale had been published that permits the assessment of model plausibility and accuracy. Here, we evaluate the predictive power of various incision models using independent data on hydraulics, bedload transport and erosion recorded on an artificial bedrock slab installed in a steep bedrock stream section for a single bedload transport event. The influence of transported bedload on the erosion rate (the "tools effect") is shown to be dominant, while other sediment effects are of minor importance. Hence, a simple temporally distributed incision model, in which erosion rate is proportional to bedload transport rate, is proposed for transient local studies under detachment-limited conditions. This model can be site-calibrated with temporally lumped bedload and erosion data and its applicability can be assessed by visual inspection of the study site. For the event at hand, basic discharge-based models, such as derivatives of the stream power model family, are adequate to reproduce the overall trend of the observed erosion rate. This may be relevant for long-term studies of landscape evolution without specific interest in transient local behavior. However, it remains to be seen whether the same model calibration can reliably predict erosion in future events

Fine‐scale measurement of diffusivity in a microbial mat with nuclear magnetic resonance imaging

Noninvasive 1H‐nuclear magnetic resonance (NMR) imaging was used to investigate the diffusive properties of microbial mats in two dimensions. Pulsed field gradient NMR was used to acquire images of the H2O diffusion coefficient, Ds, and multiecho imaging NMR was used to obtain images of the water density in two structurally different microbial mats sampled from Solar Lake (Egypt). We found a pronounced lateral and vertical variability of both water density and water diffusion coefficient, correlated with the laminated and heterogeneous distribution of microbial cells and exopolymers within the mats. The average water density varied from 0.5 to 0.9, whereas the average water diffusion coefficient ranged from 0.4 to 0.9 relative to the values obtained in the stagnant water above the mat samples. The apparent water diffusivities estimated from NMR imaging compared well to apparent O2 diffusivities measured with a diffusivity microsensor. Analysis of measured O2 concentration profiles with a diffusion‐reaction model showed that both the magnitude of calculated rates and the depth distribution of calculated O2 consumption/production zones changed when the observed variations of diffusivity were taken into account. With NMR imaging, diffusivity can be determined at high spatial resolution, which can resolve inherent lateral and vertical heterogeneities found in most natural benthic systems

Excitons in Electrostatic Traps

We consider in-plane electrostatic traps for indirect excitons in coupled quantum wells, where the traps are formed by a laterally modulated gate voltage. An intrinsic obstacle for exciton confinement in electrostatic traps is an in-plane electric field that can lead to exciton dissociation. We propose a design to suppress the in-plane electric field and, at the same time, to effectively confine excitons in the electrostatic traps. We present calculations for various classes of electrostatic traps and experimental proof of principle for trapping of indirect excitons in electrostatic traps.Comment: 4 pages, 3 figure

A Killing Disease Epidemic Among Displaced Sudanese Population Identified as Visceral Leishmaniasis.

A fatal disease epidemic affected the Bentiu area in southern Sudan and led to a mass migration of the Nuer tribe searching for treatment. The initially available information revealed a high mortality rate due to a possible occurrence of tuberculosis, malaria, enteric fever or visceral leishmaniasis (VL). Serological screening of 53 of the most severely affected patients in an enzyme-linked immunosorbent assay (ELISA) or an improved direct agglutination test (DAT) revealed positivity for VL. In 39 of those patients, diagnosis was confirmed by identification of Leishmania donovani amastigotes in lymph node or bone-marrow aspirates. In a total of 2714 patients observed, 1195 (44.0%) had clinical symptoms suggesting VL: DAT positive titers (1:3200-greater than or equal to 1:12800) were obtained in 654 (24.1%), of whom 325 were confirmed parasitologically. Forty-two VL cases died before or during treatment, giving a mortality rate of 6.4%. Among the intercurrent infections diagnosed in the VL population (654), respiratory involvements (31.7%) and malaria (10.7%) were most prevalent. With the exception of four (0.6%), all other VL patients (509) responded readily to sodium stibogluconate. The factors initiating the outbreak are discussed. Malnutrition and nomadic movements to potential VL endemic areas appeared to be the most important. HIV infection as a possible predisposition seemed remote considering the clinical and epidemiological similarity to VL occurring in East Africa, adequate humoral response in DAT, and immediate positive response to specific anti-Leishmania chemotherapy