USE OF THE SF-36 QUESTIONNAIRE IN ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION

Objective: to carry out a complex assessment of life quality (LQ) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) according to SF-36 questionnaire.Materials and methods. The study included 20 patients who underwent in-patient examination and treatment in City Clinical Hospital № 1 n.a. N.I. Pirogov (Moscow City Healthcare Department) to confirm the diagnosis of CTEPH and for selection of drug therapy. All patients completed a standardized SF-36 questionnaire. The possible association of various parameters of this questionnaire with both clinical and instrumental data of patient’s examination was studied.Results. Statistically significant correlations between the clinical symptoms of the disease, the severity of pulmonary hypertension, and the assessment of the possible physical activity of patients with CTEPH with various scales of mental and physical functioning of SF-36 questionnaire have been obtained.Conclusion. The study of QL parameters increases the possibilities for a comprehensive assessment of health status in patients with CTEPH. Based on this finding, SF-36 questionnaire can be used in routine clinical practice to assess the disease severity. Increasing the patient’s number as well as carrying out a dynamic QL study according to sex and age of patients with SF-36 questionnaire will further allow to develop additional criteria for assessing the effectiveness of therapy

What factors are Associated with the Development of Contras-induced Nephropathy in Elderly Patients with Acute Coronary Syndrome in Real Clinical Practice?

Aim. To study the factors associated with contrast-induced acute kidney injury in elderly patients with acute coronary syndrome (ACS).Material and Methods. A retrospective analysis of 514 electronic medical records of patients aged 75 years and over (38% men and 62% women) with confirmed acute coronary syndrome has been performed. The contrast-induced acute kidney injury was defined as an increase in serum creatinine ≥26.5 μmol/L in 48 h or as an increase in serum creatinine in 1.5 times within 7 days after the contrast media exposure. Patients were divided into contrast-induced acute kidney injury and non-contrast-induced acute kidney injury group. Clinical characteristics and in-hospital outcomes were extracted from patients' medical records. Procedural characteristics were obtained from laboratory database.Results. Angiographic intervention was performed in 74% of patients, 32% of them (more often in women, p=0.033) were diagnosed with contrast-induced acute kidney injury. Patients with contrast-induced acute kidney injury are characterized by a higher death rate (17% и 3%, p<0.001) and were more likely to have heart failure with reduced ejection fraction (34% и 21%, p=0.008) and acute heart failure (Killip class II-IV) (24% и 16%, p=0.015). The risk of developing contrast-induced acute kidney injury was related the volume of contrast medium administered.Conclusions. Prevention particular care should be taken to female patients older than 75 years with ACS, with a history of the chronic heart failure with reduced ejection fraction or acute heart failure (Killip class II-IV), and with a high volume of contrast media, highlighting that a perioperative comprehensive management strategy is needed to improve the prognosis