Modernization of government management in empires of new time: comparative political analysis

The article deals with the issues related to the modernization of public administration in the imperial states of modern times. Russian, British and Ottoman empires as states implementing various strategies of modernization and improvement of public administration were chosen as examples. The success of modernization reforms of the administration is one of the essential conditions for maintaining stability and development of the imperial political system, formalizing the domination of the center in relation to the periphery. The Ottoman Empire failed to implement the policy of modernization of public administration in a timely and consistent manner. The British Empire was combined the strategies of centralization and decentralization of state management of its overseas colonies. The Russian Empire - a special imperial system -implemented, within the framework of the unitary state, the principle of centralization of the system of management, but its implementation in the development of the central bureaucratic apparatus of the empire was limited by the autocratic monarchy. At the same time, the Russian Empire was flexible in terms of differentiation of the management approaches. The article substantiates the conclusion that the imperial administration was an expression of centripetal political processes in the imperial system provided them and was an expression of the political power of the center which has an autocratic character in relation to the periphery. The processes associated with the administration of the Empire are concentrated in its center and implemented in addition to the will of the periphery. In institutional terms, the center of the empire is represented by general imperial authorities and management, in functional terms, the imperial power has exclusive administrative prerogatives associated with the concentration of resources of power and their distribution over the imperial hierarchy. The differentiation of administrative approaches shows the administrative and political specificity of the empire-state. In general the modernization of management empire became a significant factor in allowing the empire to most effectively carry out the concentration of political resources

Synthesis and Characterization of Organic Impurities in Bortezomib Anhydride Produced by a Convergent Technology

A profile of impurities in bortezomib anhydride, produced by a recently developed convergent technology, has been characterized. HPLC-MS analysis of the drug essence revealed three impurities: an epimer of bortezomib, resulting from partial racemization of l-phenylalanine’s stereogenic center during the chemical synthesis, and two epimeric products of oxidative degradation of bortezomib, in which boron is replaced by the OH group. The impurities were obtained by chemical synthesis and characterized by physical methods

Collapses and revivals of polarization and radiation intensity induced by strong exciton-vibron coupling

Recently, systems with strong coupling between electronic and vibrational degrees of freedom attract a great attention. In this work, we consider the transient dynamics of the system consisting of strongly coupled vibron and exciton driven by external monochromatic field. We show that under coherent pumping, polarization of exciton exhibits complex quantum dynamics which can be divided into three stages. At the first stage, exciton oscillations at its eigenfrequency relax due to the transition to set of shifted Fock states of vibrons. We demonstrate that these shifted Fock states play the role of an effective reservoir for the excited exciton state. The time of relaxation to this reservoir depends on exciton-vibron coupling. At the second stage, excitation, transferred to the reservoir of the vibronic shifted states at the first stage, returns into electronic degrees of freedom and revival of oscillations at exciton eigenfrequency appears. Thus, the dynamics of molecular polarization exhibit collapses and revivals. At the final stage, these collapses and revivals dissipate and polarization exhibits Rayleigh response at the frequency of the external field. Discovered collapses and revivals manifest in radiation spectrum as multiple splitting of the spectral line near the exciton transition frequency

Thermalization rate of polaritons in strongly-coupled molecular systems

Polariton thermalization is a key process in achieving light-matter Bose--Einstein condensation, spanning from solid-state semiconductor microcavities at cryogenic temperatures to surface plasmon nanocavities with molecules at room temperature. Originated from the matter component of polariton states, the microscopic mechanisms of thermalization are closely tied to specific material properties. In this work, we investigate polariton thermalization in strongly-coupled molecular systems. We develop a microscopic theory addressing polariton thermalization through electron-phonon interactions (known as exciton-vibration coupling) with low-energy molecular vibrations. This theory presents a simple analytical method to calculate the temperature-dependent polariton thermalization rate, utilizing experimentally accessible spectral properties of bare molecules, such as the Stokes shift and temperature-dependent linewidth of photoluminescence, in conjunction with well-known parameters of optical cavities. Our findings demonstrate qualitative agreement with recent experimental reports of nonequilibrium polariton condensation in both ground and excited states, and explain the thermalization bottleneck effect observed at low temperatures. This study showcases the significance of vibrational degrees of freedom in polariton condensation and offers practical guidance for future experiments, including the selection of suitable material systems and cavity designs