Harmonious project and program management in a changing environment

Constantly changing environmental conditions, in addition to the lack of resources, are one of the biggest obstacles in the implementation of various projects and programs. Currently, companies associated with project management are trying to identify approaches that will allow them to effectively manage projects and programs in an unstable environment. The article examines such promising approaches to project management as sustainable, “green”, value-based project management. The paper analyses the experience of foreign and domestic companies in applying these approaches in their activities. The authors define the main methodological recommendations and standards on the basis of which project management is carried out within the framework of these approaches

Sustainable project management as a tool for increasing the economic effect of technological innovations

Currently, companies are searching for ways to develop and ensure competitiveness in the market and are increasingly resorting to the introduction of technological innovations, using the methodology of project management. The article investigates such current approaches to project management as flexible, lean, sustainable and elastic project management. The concept of technological innovations is defined. The situation on the introduction of technological innovations in Russia and in foreign countries is analysed. The indicators for assessing the economic efficiency of the introduction of technological innovations are determined. The relationship between the use of these approaches to project management and increasing the economic effect of the introduction of technological innovations is revealed

Impact of Industry 4.0 on the economy and production

The difficulties and problems faced by economic entities, countries and regions, in general, on the way to implementing the achievements and developments of Industry 4.0 have been designated in the article. Special attention has been paid to economic and production aspects, as well as changes in the relevant systems in the context of radical technological transformations. In particular, it has been established that markets are becoming oligopolistic, the role and importance of medium and small businesses is significantly increasing, the problems of social inequality and tension in connection with growing unemployment and the need for highly qualified personnel are becoming more acute. In addition, the features of competition for technologies, investments, sales markets, territories of productive forces location have been highlighted. Attention has also been focused on the main “revolutionary” trends in industrial development associated with the launch of the innovation and technological cycle initiated by “Industry 4.0”. Specific actions and measures have been identified to implement these trends into reality

Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia

Materials and methods. This retrospective case-control study enrolled 50 women with severe preeclampsia and 50 control women with spontaneous singleton pregnancy. Median age of women ranged from 20 to 35 years. All women did not have a history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and preeclampsia before this pregnancy. We have analyzed χ2, odds ratio (OR) and its 95% confidence intervals (95% Cl). Results. We found significant association between maternal systemic infectious and severe preeclampsia (OR = 49.6; 95% Cl 13.05-188.64). The risk of severe preeclampsia were significantly lower in patients with local infections of the lower genital tract (OR = 4.5; 95% Cl 1.49-6.71). Asymptomatic bacteriuria is associated with the highest risk of severe preeclampsia (OR = 17.0; 95% Cl 4.66-61.81). Acute gravidarum pyelonephritis showed lower association with severe preeclampsia (OR = 5.4; 95% Cl 1.69-10.54). We did not observe increased risk of severe preeclampsia with acute respiratory infections (OR = 2.0; 95% Cl 0.71-4.69). Acute non-specific bacterial vaginitis and acute candidiasis vulvovaginitis were found to be risk factors of severe preeclampsia (OR = 6.7; 95% Cl 1.90-11.02 and OR = 4.3; 95% Cl 1.45-9.99 respectively). Cytomegalovirus infection (2 %), toxoplasmosis (2 %), Chlamydia trachomatis cervicitis (4 %), acute Trichomonas colpitis (2 %) and bacterial vaginosis (4 %) were found only in patients with severe preeclampsia. Conclusion. Our data support that acute maternal infection is associated with an increased risk of severe preeclampsia in healthy women with singleton pregnancy. Systemic inflammatory response might be the main potential mechanisms related to infections and enhanced development of severe preeclampsia. Further research is required to elucidate the underlying mechanism of this association