Platelets of unstable angina patients as effector cells in terahertz radiation at NO frequency

Aim. To investigate the effects of electromagnetic terahertz waves at NO MSIP (molecular specter of radiation and absorption), 240 Hz, on platelet functional activity Р in natural electromagnetic field, as well as in crossed magnetic and electric fields among unstable angina patients. Material and methods. This in vitro study was performed on samples of platelet-enriched plasma from 120 unstable angina patients. The study of terahertz waves and platelets interaction at NO MSRA specter, 240 GHz, was performed with original quasi-optic SW generator of determined noises (CRIMD, Saratov). Functional activity of platelets (activation and aggregation) was measured by laser aggregation analyzer (Biola-230 Ltd.). Results. After in-vitro radiation of platelet-enriched plasma from unstable angina patients, at NO MSRA frequency, 240 GHz, disturbed platelet aggregation activity was normalized. Conclusion. Therefore, terahertz waves, at NO frequency, 240 GHz, substantially decreased elevated aggregation activity of the platelets from unstable angina patients

ВОССТАНОВЛЕНИЕ ТКАНЕВОГО КРОВОТОКА У КРЫС ПОСЛЕ ВВЕДЕНИЯ МЕЗЕНХИМАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК В ТРОМБИРОВАННУЮ ВЕНУ

Методами люминесцентной микроскопии изучали результаты введения аутологичных мультипотентных мезенхимальных стволовых клеток костномозгового происхождения (АМСККП) с геном GFP в тромбированную вену задней конечности крыс. Было обнаружено, что естественный тромболизис, приводящий к восстановлению кровотока в тромбированной магистральной вене, препятствует встраиванию введенных АМСККП в стенку тромбированного сосуда. В мелких ветвях, отходящих от магистральной вены после моделирования тромбоза, также происходит тромбирование просвета с восстановлением кровотока через реканализацию тромба или за счет формирования новых сосудов на месте облитерированных. Обнаруженные АМСККП в мелких сосудах характеризуют участие их в этих процессах, что приводит к более быстрому восстановлению кровотока в тканевом микрорайоне пораженной вены с последующей репарацией собственных клеток организма-реципиента.</font

THE INFLUENCE OF VHF ELECTROMAGNETIC RADIATION ON THE FREQUENCIES OF MOLECULAR SPECTRUM AND OXYGEN ABSORPTION ON BLOOD REOLOGICAL PROPERTIES IN STABLE ANGINA

The results of studing main features of influence of electromagnetic radiation of atmosphere oxygen molecular spectra of irradiation and absorption frequencies on whole blood rheology of patients with stable angina pectoris were present. The changes of rheological properties of whole blood samples of the patients with stable angina pectoris irradiated with electromagnetic radiation of atmosphere oxygen molecular spectra of irradiation and absorption frequencies depend on the time of treating, initial haematocrit level, fibrinogen concentration and arterial blood pressure

Electro-magnetic radiation of terahertz range, NO molecular specter frequencies, and coagulation hemostasis in patients with various angina forms

Aim. To study hypocoagulation effectiveness and mechanisms of electro-magnetic radiation, terahertz range, NO molecular specter frequencies (EMR THF-NO), in patients with various angina forms. Material and methods. The authors examined 80 patients with unstable angina, Class IIA and IIB (E. Braunwald classification), or effort angina, Functional Class II-IV (Canadian Cardiovascular Society). Twenty patients received standard medication therapy plus EMR THF-NO. Noteworthy, EMR THF-NO effects in unstable angina (UA) were studied in the absence of heparin therapy. The effects on main hemostatic parameters were studied: activated partial thromboplastin time (APTT), activated recalcification time (ART), prothrombin time, euglobulin fibrinolysis, fibrinogen (F) levels, antithrombin-III (At-III) activity, complex parameter of protein C system disturbances, Va factor resistance to activated C-protein. Results. EMR THF-NO demonstrated hypocoagulation effect in patients with stable angina (SA) and UA. In SA, hypocoagulation mechanism is explained by procoagulation potential reduction, by affecting the first (APTT and ART increase) and the third (F level decrease) coagulation phases. In US, it’s explained by increase in anticoagulant potential, due to At-III and modulation of initially disturbed fibrinolysis. Conclusion. EMR THF-NO should be included into complex therapy of angina patients, for greater hypocoagulation effect. EMR THF-NO could be used as an alternative method in patients with hypercoagulation and contraindications to special pharmaceutical hypocoagulation, or intolerance to these medications