Лучевые методы в диагностике удвоения желудка у детей

Introduction. Stomach doubling is one of the rarest types of gastrointestinal doubling in the system of pathology of abdominal organs in children. Stomach doubling occurs in 4–8% of cases of gastrointestinal doubling. To a greater extent, it is diagnosed in girls. The rarest localization of doubling is a small curvature of the stomach — 7%.The purpose of the study: to present the informative value of radiation methods in the diagnosis of gastric doubling by the example of a clinical case.Material and methods. The work is based on the analysis of clinical data, instrumental, histological studies performed in a children’s hospital in St. Petersburg.Results: An 8-year-old patient was hospitalized for further examination for cystic formation of the abdominal cavity, detected antenatally at 36 weeks of gestation. At the age of 2 years, MSCT angiography of the abdominal cavity was performed and a differential series between a liver cyst and a doubling of the stomach was exposed. At the control ultrasound, further negative dynamics in size. An MRI revealed that the picture most likely corresponds to a cystic doubling of the stomach. Indications for surgical treatment are exposed. Histologically confirmed variant of stomach doubling.Conclusion. The multimodal approach allows timely diagnosis of the presented pathology, differential diagnosis of gastric doubling with rare localization and determination of indications for surgical treatment. Введение. Удвоение желудка — один из наиболее редких типов удвоения желудочно-кишечного тракта в системе патологии органов брюшной полости у детей. Удвоение желудка встречается в 4–8% случаев удвоения ЖКТ. В большей степени диагностируется у девочек. Наиболее редкой локализацией удвоения является малая кривизна желудка — 7%.Цель исследования: представить информативность лучевых методов в диагностике удвоения желудка на примере клинического случая.Материалы и методы. Работа основана на анализе клинических данных, инструментальных, гистологических исследований, выполненных в детском стационаре Санкт-Петербурга.Результаты. Пациентка 8 лет, была госпитализирована для дообследования по поводу кистозного образования брюшной полости, обнаруженного на 36-й неделе гестации антенатально. В возрасте 2 лет выполнено МСКТ-ангиографии брюшной полости и выставлен дифференциальный ряд между кистой печени и удвоением желудка. На контрольных УЗИ в дальнейшем отрицательная динамика в размерах. На МРТ выявлено, что картина наиболее вероятно, соответствует кистозному удвоению желудка. Выставлены показания к хирургическому лечению. Гистологически подтвержден вариант удвоения желудка.Заключение. Мультимодальный подход позволяет своевременно диагностировать представленную патологию, провести дифференциальную диагностику удвоения желудка с редкой локализацией и определить показания к хирургическому лечению.

Investigation of the Relationship between the S1 Domain and Its Molecular Functions Derived from Studies of the Tertiary Structure

S1 domain, a structural variant of one of the “oldest” OB-folds (oligonucleotide/oligosaccharide-binding fold), is widespread in various proteins in three domains of life: Bacteria, Eukaryotes, and Archaea. In this study, it was shown that S1 domains of bacterial, eukaryotic, and archaeal proteins have a low percentage of identity, which indicates the uniqueness of the scaffold and is associated with protein functions. Assessment of the predisposition of tertiary flexibility of S1 domains using computational and statistical tools showed similar structural features and revealed functional flexible regions that are potentially involved in the interaction of natural binding partners. In addition, we analyzed the relative number and distribution of S1 domains in all domains of life and established specific features based on sequences and structures associated with molecular functions. The results correlate with the presence of repeats of the S1 domain in proteins containing the S1 domain in the range from one (bacterial and archaeal) to 15 (eukaryotic) and, apparently, are associated with the need for individual proteins to increase the affinity and specificity of protein binding to ligands

Distribution of the mechanical properties of metal in local zones of a welded joint

Translated from Russian (Svar. Proizvod. 1998 (11) p. 3-6)Available from British Library Document Supply Centre-DSC:9023.190(VR-Trans--8764)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Distribution of the mechanical properties of metal in local zones of a welded joint

Translated from Russian (Svar. Proizvod. 1998 (11) p. 3-6)Available from British Library Document Supply Centre-DSC:9023.190(VR-Trans--8764)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo