CAUSES OF TREATMENT DEFAULTS IN THOSE SUFFERING FROM MULTIPLE DRUG RESISTANCE TUBERCULOSIS IN KYRGYZSTAN REPUBLIC

The article is devoted to studying the causes of treatment defaults in those suffering from multiple drug resistance tuberculosis in Kyrgyzstan Republic, treated in 2005-2012

ПРИЧИНЫ ОТРЫВОВ ОТ ЛЕЧЕНИЯ БОЛЬНЫХ ТУБЕРКУЛЕЗОМ С МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ ВОЗБУДИТЕЛЯ В КЫРГЫЗСКОЙ РЕСПУБЛИКЕ

The article is devoted to studying the causes of treatment defaults in those suffering from multiple drug resistance tuberculosis in Kyrgyzstan Republic, treated in 2005-2012.Статья посвящена изучению причин отрывов от лечения больных туберкулезом с множественной лекарственной устойчивостью возбудителя в Кыргызской Республике, получавших лечение в 2005-2012 гг

Заболеваемость туберкулезом внелегочных локализаций на территории Кыргызской Республики

Extrapulmonary tuberculosis is widespread in the territory of the Kyrgyz Republic (KR). General practitioners fail to diagnose in time a significant number of cases of extrapulmonary tuberculosis. In the Kyrgyz Republic, in 2019 the incidence of extrapulmonary tuberculosis made 19.5 per 100,000 population, tuberculous exudative pleurisy (50.6%) and bone and joint tuberculosis (18.1%) prevailed in the structure.Внелегочный туберкулез (ВЛТ) широко распространен на территории Кыргызской Республики (КР). Значительное число случаев ВЛТ не распознается своевременно врачами общей практики. В КР заболеваемость туберкулезом внелегочных локализаций в 2019 г. составила 19,5 на 100 тыс. населения, в структуре превалируют туберкулезный экссудативный плеврит (50,6%) и костно-суставной туберкулез (18,1%)

FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS

During the chemotherapy, frequency and characteristics of adverse reactions to second line anti-tuberculosis drugs in 324 patients ill with multiple drug resistant tuberculosis were investigated. The majority of patients (319 - 98.4%) had various adverse reactions to second line anti-tuberculosis drugs.Adverse reactions caused by one or two drugs provided no negative impact on treatment efficiency. As the number of poorly tolerated drugs increased, the level of favorable treatment outcomes went down, whereby the significant confident correlation was observed between adverse outcomes and poor tolerance of 3 and more anti-tuberculosis drugs p = 0.000, r = +> 0.9. There was doubtful correlation observed between poor tolerance anti-tuberculosis drugs and cases deaths (p > 0.05, r = +> 0.3). The doubtful correlation was also observed between cases of lost from treatment and poor tolerance of anti-tuberculosis drugs, p > 0.05, r = +> 0.3