Performance optimization of InGaAs/InP SPADs for either low noise or high photon detection efficiency applications

InGaAs/InP Single-Photon Avalanche Diodes ( SPADs) can achieve high photon detection efficiency (PDE) with a thick absorber, but at the expense of higher dark count rate ( DCR). PDE and DCR also depend on the electric field inside the structure, which can be tailored in the design phase and influences the overall performance. We present the design and the experimental characterization of two different 10 mu m-diameter InGaAs/InP SPADs. The first one is intended for applications where low noise is the key requirement: at 225 K and 5 V excess bias, it features 1 kcps DCR, 25% PDE at 1550 nm and a timing jitter of 100 ps (FWHM). The second device is an InGaAs/InP SPAD optimized for PDE-enhanced applications, having a PDE up to 50% at 1550 nm, with a DCR of 20 kcps and a timing jitter of 70 ps (FWHM) at 225 K. Alternatively, it features a PDE of 37% at 1550 nm, with a DCR of just 3 kcps and a timing jitter of 100 ps (FWHM). When combined with a custom integrated circuit we developed, both devices show an afterpulsing probability as low as few percent with a gating frequency of 1 MHz and hold-off time of few microseconds at 225 K, allowing to achieve a photon count rate towards 1 Mcps

Anomalous diffusion in the dynamics of complex processes

Anomalous diffusion, process in which the mean-squared displacement of system states is a non-linear function of time, is usually identified in real stochastic processes by comparing experimental and theoretical displacements at relatively small time intervals. This paper proposes an interpolation expression for the identification of anomalous diffusion in complex signals for the cases when the dynamics of the system under study reaches a steady state (large time intervals). This interpolation expression uses the chaotic difference moment (transient structural function) of the second order as an average characteristic of displacements. A general procedure for identifying anomalous diffusion and calculating its parameters in real stochastic signals, which includes the removal of the regular (low-frequency) components from the source signal and the fitting of the chaotic part of the experimental difference moment of the second order to the interpolation expression, is presented. The procedure was applied to the analysis of the dynamics of magnetoencephalograms, blinking fluorescence of quantum dots, and X-ray emission from accreting objects. For all three applications, the interpolation was able to adequately describe the chaotic part of the experimental difference moment, which implies that anomalous diffusion manifests itself in these natural signals. The results of this study make it possible to broaden the range of complex natural processes in which anomalous diffusion can be identified. The relation between the interpolation expression and a diffusion model, which is derived in the paper, allows one to simulate the chaotic processes in the open complex systems with anomalous diffusion.Comment: 47 pages, 15 figures; Submitted to Physical Review

Synthesis and characterization of belite calcium sulfoaluminate cements produced by oxyfuel combustion residues

In this work, the possibility of reusing ashes issued by an oxyfuel combustion process (OC) as a source of material in the production of belite calcium sulfoaluminate BCSA cements has been investigated. OF process is one of the most promising combustion technologies for CO2 reduction from power plants. Combustion tests were carried out in an oxyfuel bubbling fluidized bed pilot plant. Four BCSA clinker-generating raw mixes were heated in a laboratory electric oven in the temperatures range 1150°-1350°C: one included only natural materials (limestone, clay, bauxite and gypsum), the others contained OC ashes as total substitute for clay. X-ray diffraction (XRD) analysis on the burning products showed high conversion of reactants toward the main BCSA clinker components (C2S and C4A3$), especially at 1200° or 1250°C. Moreover, physical-mechanical tests associated with XRD and differential thermal-thermogravimetric analyses accomplished on all the cements (obtained by adding natural gypsum to the clinkers produced at the best synthesis temperatures) generally displayed a similar hydration behaviour

Benefits and medium-term outcome of the Sorin Pericarbon Freedom stentless aortic prosthesis in cases of acute bacterial endocarditis

OBJECTIVES The aim of this study is to evaluate the ease of use and the advantages of Sorin Pericarbon Freedom (SPF) stentless valve in cases of acute bacterial endocarditis and to check the intermediate-term results after the implant of SPF with respect to resistance to infection, valve deterioration and durability. METHODS Between June 2003 and February 2015, 26 patients with active aortic valve bacterial endocarditis underwent aortic valve replacement with SPF pericardial stentless aortic prosthesis. The mean age was 57 \ub1 18 years; 73% of the patients were in preoperative NYHA class III and VI. Mean Logistic EuroSCORE was 14.2 \ub1 12.7. Endocarditis occurred in 18 patients with native valves, and in 9 patients with prosthetic valves (4 mechanical aortic valve prostheses; 5 aortic bioprostheses). Aortic root abscesses were observed in 16 cases (61.5%). Surgery was emergent in 3 cases (11.5%). Redo surgery was performed in 9 cases (35%). Cumulative follow-up was 126.8 patient-years (mean 4.9 \ub1 3.3 years). RESULTS Operative hospital mortality was 0% for all patients. Residual mean prosthetic gradient at discharge was 9.4 \ub1 3.6 mmHg. Neither residual aortic incompetence nor residual abscess cavity was observed at discharge. Mean ejection fraction at discharge was 54 \ub1 8% (Min; Max: 35%; 65%). A total of 4 patients died at follow-up, all for non-cardiac causes. One patient was lost to follow-up. Two patients (8%) underwent non-valve-related reoperation with 0% mortality. Residual mean gradient at follow-up was 7.2 \ub1 2.1 mmHg. Three patients (17%) presented with mild/moderate aortic incompetence and 89% of patients were in NYHA Class I-II at follow-up. At 9 years, actuarial freedom from valve-related reoperation and from structural valve deterioration was 100%. CONCLUSIONS The SPF aortic prosthesis is a true pericardial stentless prosthesis suitable for the treatment of acute bacterial endocarditis. Intermediate-time results in terms of freedom from reoperation, structural valve deterioration and resistance to infections are satisfactory. Haemodynamic performances are excellent since a complete exclusion of aortic root abscesses is achieved without any reduction of the aortic annular diameter, usually due to marsupialization or patch closure of the infected cavities

Breast tumor cell invasion and pro-invasive activity of cancer-associated fibroblasts co-targeted by novel urokinase-derived decapeptides

Among peritumoral cells, cancer-associated fibroblasts (CAFs) are major facilitators of tumor progression. This study describes the effects of two urokinase-derived, novel decapeptides, denoted as Pep 1 and its cyclic derivative Pep 2. In a mouse model of tumor dissemination, using HT1080 fibrosarcoma cells, Pep 2 reduced the number and size of lung metastases. Specific binding of fluoresceinated Pep 2 to HT1080 and telomerase immortalised fibroblasts (TIF) cell surfaces was enhanced by αv overexpression or abolished by excess vitronectin, anti-αv antibodies or silencing of ITGAV αv gene, identifying αv-integrin as the Pep 2 molecular target. In 3D-organotypic assays, peptide-exposed TIFs and primary CAFs from breast carcinoma patients both exhibited a markedly reduced pro-invasive ability of either HT1080 fibrosarcoma or MDA-MB-231 mammary carcinoma cells, respectively. Furthermore, TIFs, either exposed to Pep 2, or silenced for αv integrin, were impaired in their ability to chemoattract cancer cells and to contract collagen matrices, exhibiting reduced α-smooth muscle actin (α-SMA) levels. Finally, peptide exposure of αv-expressing primary CAFs led to the downregulation of α-SMA protein and to a dramatic reduction of their pro-invasive capability. In conclusion, the ability of the novel decapeptides to interfere with tumor cell invasion directly and through the down-modulation of CAF phenotype suggests their use as lead compounds for co-targeting anti-cancer strategies

Analytic approach to stochastic cellular automata: exponential and inverse power distributions out of Random Domino Automaton

Inspired by extremely simplified view of the earthquakes we propose the stochastic domino cellular automaton model exhibiting avalanches. From elementary combinatorial arguments we derive a set of nonlinear equations describing the automaton. Exact relations between the average parameters of the model are presented. Depending on imposed triggering, the model reproduces both exponential and inverse power statistics of clusters.Comment: improved, new material added; 9 pages, 3 figures, 2 table

Tuning of the excited state properties of phenylenevinylene oligomers:A time-dependent density functional theory study

This paper discusses a time-dependent density functional theory study of the effect of molecular structure on the excited state polarizability of conjugated molecules. A short phenylenevinylene oligomer containing three phenyl rings (PV2, distyryl benzene) is taken as a model system. Introduction of methyl substituents is shown to have only a small influence on the increase in polarizability upon excitation (the excess polarizability, Delta(alpha) over bar). Methoxy groups have a much larger effect but in this case Delta(alpha) over bar depends strongly on the dihedral angle between the side chain and the backbone of the molecule. If the central phenyl ring of PV2 has a meta-configuration rather than para, both the optical absorption spectrum and the excess polarizability change considerably. (C) 2003 American Institute of Physics

Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa

In spermatozoa, the nuclear F-actin supports the acroplaxome, a subacrosomal structure involved in the correct exposure of several acrosomal membrane proteins; among them, the glycoprotein IZUMO1 is the major protein involved in sperm-oocyte fusion. Nuclear F-actin is also involved in sperm head shaping and chromosome compartmentalization. To date, few notions regarding the bivalent role of F-actin on sperm chromatin organization and IZUMO1 positioning have been reported. In our work, we characterized subcellular organization of F-actin in human high- and low-quality spermatozoa (A- and B-SPZ), respectively, showing that F-actin over-expression in sperm head of B-SPZ affected IZUMO1 localization. A correct IZUMO1 repositioning following in vitro induction of F-actin depolymerization, by cytochalasin D treatment, occurred. Interestingly, F-actin depolymerization was also associated with a correct acrosome repositioning, thus to favor a proper acrosome reaction onset, with changes in sperm nuclear size parameters and histone acetylation rate reaching high-quality conditions. In conclusion, the current work shows a key role of F-actin in the control of IZUMO1 localization as well as chromatin remodeling and acetylation events

Comparing the performance of FA, DFA and DMA using different synthetic long-range correlated time series

Notwithstanding the significant efforts to develop estimators of long-range correlations (LRC) and to compare their performance, no clear consensus exists on what is the best method and under which conditions. In addition, synthetic tests suggest that the performance of LRC estimators varies when using different generators of LRC time series. Here, we compare the performances of four estimators [Fluctuation Analysis (FA), Detrended Fluctuation Analysis (DFA), Backward Detrending Moving Average (BDMA), and centred Detrending Moving Average (CDMA)]. We use three different generators [Fractional Gaussian Noises, and two ways of generating Fractional Brownian Motions]. We find that CDMA has the best performance and DFA is only slightly worse in some situations, while FA performs the worst. In addition, CDMA and DFA are less sensitive to the scaling range than FA. Hence, CDMA and DFA remain "The Methods of Choice" in determining the Hurst index of time series.Comment: 6 pages (including 3 figures) + 3 supplementary figure

The Improvement of Durability of Reinforced Concretes for Sustainable Structures: A Review on Different Approaches

The topic of sustainability of reinforced concrete structures is strictly related with their durability in aggressive environments. In particular, at equal environmental impact, the higher the durability of construction materials, the higher the sustainability. The present review deals with the possible strategies aimed at producing sustainable and durable reinforced concrete structures in different environments. It focuses on the design methodologies as well as the use of unconventional corrosion-resistant reinforcements, alternative binders to Portland cement, and innovative or traditional solutions for reinforced concrete protection and prevention against rebars corrosion such as corrosion inhibitors, coatings, self-healing techniques, and waterproofing aggregates. Analysis of the scientific literature highlights that there is no preferential way for the production of “green” concrete but that the sustainability of the building materials can only be achieved by implementing simulta-neous multiple strategies aimed at reducing environmental impact and improving both durability and performances