Estudio del apoyo metatarsal en bipedestación mediante podoscopio electrónico de alta resolución.

Con el jin de estudiar el apoyo metatarsal en bipedestación se han realizado 780 registros en la plataforma PDS 93, correspondientes a 390 individuos, no seleccionados, sin patología de la marcha, 234 varones y 156 mujeres, con edades comprendidas entre 24 y 41 años (edad media de 29,9 años). En cada registro se ha recogido la presión ejercida por cada metatarsiano, relacionando la carga obtenida con el peso, conjiguración mecánica del pie y huella plantar: Los resultados obtenidos se han procesado estadísticamente por medio del programa SPSS. El porcentaje de las cargas medias obtenidas para cada metatarsiano han sido: 16,85, 21,25, 23,88, 20,24 y 17,78%, existiendo dqerencias sign$cativas para el apoyo de los metatarsianos centrales (p < 0,001). Todos los metatarsianos soportan carga en bipedestación, de acuerdo con las teorías actuales. Sin embargo, aunque la distribución del peso para el primer metatarsiano se aproxima al doble de los otros, la carga máxima en g/cm2 se realiza en los metatarsianos centrales

Creative group performances to assess core competencies in a first-year patient-centered medicine course

Introduction: A novel assessment of systems-based practice and practice-based learning and improvement learning objectives, implemented in a first-year patient-centered medicine course, is qualitatively described. Methods: Student learning communities were asked to creatively demonstrate a problem and solution for health care delivery. Skits, filmed performances, plays, and documentaries were chosen by the students. Video recordings were reviewed for themes and the presence of course competencies. Results: All performances demonstrated not only the index competencies of team work and facilitation of the learning of others, but many other core objectives of the course. The assignment was rated positively both by the faculty and the students, and has been added to the assessment modalities of the course

Application of hierarchical Bayesian unmixing models in river sediment source apportionment

1 .pdf copy (1 Pag.) of the abstract published by the Organization. © Author(s) 2016. CC Attribution 3.0 License.In this contribution, key components of the model are evaluated in the context of common experimental designs for sediment fingerprinting studies namely simple, nested and distributed catchment sampling programmes. Illustrative examples using geochemical and compound specific stable isotope datasets are presented and used to discuss best practice with specific attention to (1) the tracer selection process, (2) incorporation of fixed effects relating to sample timeframe and sediment type in the modelling process, (3) deriving and using informative priors in sediment fingerprinting context and (4) transparency of the process and replication of model results by other users.Peer reviewe

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 x10(-8)), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD